Together with Consulting Editor Dr. Lucky Jain, Dr. Sudarshan R. Jadcherla has put together a comprehensive issue devoted to neonatal gastroenterology. Expert authors have contributed clinical review articles on the following topics: Neonatal Aerodigestive Disorders: Epidemiology and Economic Burden; Feeding and Swallowing Difficulties in Neonates: Developmental Physiology and Pathophysiology; Gastroesophageal Reflux Disease in the NICU Neonate: Controversies, Current Understanding and Future Directions; Feeding Difficulties and Tube-feeding Controversies in Complex Neonates: Evidence-Based Practices; Physiology and Pathological basis of Aerodigestive Difficulties in Chronic Lung Disease; Congenital Diarrheas in Infants: Pathophysiology, Consequences, and Potential Treatment Strategies; Short Gut syndrome: Recent Advances in Pathophysiology and Intestinal Support Practices; Neonatal Cholestasis in the Premature Infant: Approaches to Diagnosis and Management; Strategies for Prevention of TPN-related Liver Injury; Supplements and Additives to Human Milk: Principles and Practices, Current Controversies; Microbiome and Gut Injury in Neonates; Recent Advances in NEC Research: Strategies for Implementation in Clinical Practice; Transfusion-Related Gut Injury and NEC; Neonatal Endoscopy, Diagnosis and Intervention Procedures Crib-side; and Surgical Gastrointestinal Emergencies in Neonates: An overview. Readers will come away with the information they need to improve outcomes in the neonate.

In collaboration with Consulting Editor, Dr. Lucky Jain, Guest Editor Dr. Daniel Wechsler has assembled expert authors to provide a current update on the diagnosis and treatment of neonatal malignant disorders. Articles are specifically devoted to the following topics: Genetic Predisposition and Neonatal Cancer; Infant Leukemias; Neonatal Malignant Disorders: Brain Tumors; Retinoblastoma; Neonatal Malignant Disorders: Kidney Tumors; Neonatal Malignant Disorders: Liver Tumors; Neuroblastoma; Neonatal Malignant Disorders: Sarcoma; Neonatal Malignant Disorders: Germ Cell Tumors; Neonatal Histiocytoses; Lymphatic Malformations; and Long-Term Outcomes in Neonatal Cancer Survivors. Readers will come away with the information they need to improve outcomes in infants with neonatal malignant disorders.

Together with Consulting Editor Dr. William Rayburn, Guest Editors Dr. Cynthia Gyamfi-Bannerman and Dr. Russel Miller have curated a state-of-the-art monograph devoted to Advances in Maternal Fetal Medicine. They have secured expert authors to submit clinical reviews for perinatologists. Specific articles are devoted to the following topics: Advances in delivery management for the preterm fetus (magnesium sulfate, late-preterm antenatal corticosteroids); Approaches to stillbirth prevention; Current preterm birth prevention strategies; Neurological outcomes after fetal therapy for complicated monochorionic twins; Innovations in fetal myelomeningocele (fMMC) repair; An update on biologic agents in pregnancy; Telemedicine in obstetrics; The impact of racial and socioeconomic disparities on obstetrical outcomes; Opioids use and misuse in pregnancy; Advances in statewide and national obstetrical QI collaborations; Optimizing term delivery timing and mode of delivery; Preeclampsia; E-Z infections can be quite challenging: Contemporary understanding of Ebola and Zika virus in pregnancy; and Next-generation genetic testing in obstetrics. Readers will come away with the evidence-based recommendations they need to improve patient outcomes.maternal fetal medicine; fetus; pregnancy;

In consultation with Consulting Editor, Dr. Lucky Jain, Drs. Maximo Vento and Waldemar Carlo have put together a state-of the-art issue of the Clinics in Perinatology devoted to Perinatal Pharmacology. Clinical review articles are specifically devoted to the following: Monitoring and assessment of oxygenation in infants; Oxygen toxicity in neonates; New methods for non-invasive oxygen administration; Targeting oxygen in preterm and term infants starting at birth; Newborn resuscitation in settings without access to supplemental oxygen; Noninvasive versus invasive ventilatory support; Nasal SIMV versus Nasal CPAP before and after invasive ventilatory support; Is high-flow cannula inferior to CPAP for neonates?; Intermittent hypoxia: Importance; Closed-loop control of inspired oxygen in neonates: Compliance with targets; Meta-analysis oxygenation saturation targeting trials: Do infant subgroups matter?; Targets of oxygen saturation to optimize eye outcomes; Achieved oxygenation saturations and outcome in extremely preterm infants; Pulmonary hypertension in preterm infants; and Current recommendations and practice of oxygen therapy in preterm infants. Readers will come away with the latest information on oxygen therapy as they seek to utilize evidence-based recommendations to improve patient outcomes.

In collaboration with Consulting Editor, Dr. Lucky Jain, Drs. Robert Kliegman and Bret Bordini have put together topics that provide a current clinical update on the treatment and management of undiagnosed and rare diseases in the neonate. Expert authors have contributed clinical review articles on the following topics: Neonatal Liver Failure; Neonatal Autoinflammatory Disorders; Rare or Unusual Dermatologic Disorders In Neonates; Neonatal Immune Deficiency; Congenital Diarrhea Syndromes; Nonimmune Hydrops; DNA Depletion Syndromes; Genomic Approach to Dysmorphology Syndromes; Nonimmune Anemias; Severe Metabolic Crisis (Metabolic Acidosis, Unresponsive Hypoglycemia, Hyperammonemia); Heterotaxia Syndromes; Neonatal Appendicitis; Avoiding Diagnostic Errors in Neonatology; and Differentiating Congenital Myopathy from Congenital Muscular Dystrophy. Readers will come away with the information they need to improve outcomes in the neonate.

In consultation with Dr. Lucky Jain, Consulting Editor, Drs. Dempsey and EL-Khuffash have chosen a wide range of topics in cardiovascular issues that cover new diagnostic techniques and important areas of management, including the role of volume administration, inotropes, and corticosteroids in the setting of cardiovascular instability. These remain critical questions in neonatal care, and authors were selected based on their expertise and ability to provide the reader with the most recent up-to-date evidence upon which to direct intervention. The clinical review articles in this issue will address the relationship between intervention and outcome in preterm hypotension, the management of cardiovascular instability in the setting of pulmonary hypertension and therapeutic hypothermia, and finally ask if it's time for a definitive trial in the management of PDA. The final article in the issue highlights the clinical trials to date, what trials are currently ongoing, and what the future holds in cardiovascular support for the preterm infant. The reader will come away with the most current information on this topic from international experts including Europe, Canada, USA, and Australia.

Hadi Practical Neonatology (Hadi PN), a 2-book series of practical guidelines, is intended to provide a structured approach to the management of neonatal conditions which are likely to face the neonatal team. It is not intended to replace neonatal textbooks or to teach the beginners in the field. Prior sound knowledge of Neonatal Medicine, by the user, is essential. This book is the second in the series. It covers aspects of NEUROLOGY-FLUIDS & ELECTROLYTES, VASCULAR ACCESS & SAMPLING, FREQUENT CHALLENGES , HAEMATOLOGY, JAUNDICE and ESSENTIAL PROCEDURES&PRACTICES challenges. It is my belief that neonatal doctors and nurses are an integrated team, and any demarcation is an imaginary line. The recipe of creating a backbone of good nurses is passionate support, continuous education, and practical teaching at every possible opportunity. Mutual trust and appropriate delegations are crucial to the success of the team. HADI PN series is written for the neonatal team and not just for the medical staff. The best way for consolidating the team knowledge and experience is bedside teaching. New methods and approaches of neonatal management are progressing but seem to slow down over the last 2-3 years. This may reflect the fact neonatal advances are approaching our era peak of “what is possible.” Nevertheless, many of our current practices are yet to be scrutinized to fulfil the evidence-based pathways and standards. There is no robust verification of our current practice of many routine day to day applications. This include but not limited to fluid requirements, duration of antibiotics courses, use of various blood products, and seizures pharmacological treatment. I have reviewed multiple neonatal medical and nursing guidelines from Europe, North America, and Australia as well as guidelines from Asia, South America, and Africa. I integrated many aspects from these guidelines within this text whenever they are in accord with the international acceptable practices. Feedback and suggestions are welcome and can be sent to [email protected] The book is an updated version of the protocols and guidelines which I have developed during my work as Consultant Neonatologist. Many are adopted from various reputable institutes and modified to reflect the current evidence plus a slight flavour of my experience. Considerable effort has been exercised to ensure the doses of medications given in HADI PN are accurate. However, further confirmation by the nursing and medical staff is advised prior to the first use of each medication. HADI PN reflects the author’s own acceptable and safe practice and advice. It is written with the intention of facilitating the delivery of care to the most vulnerable newborn. The publication is written bearing in mind the wide variations in the skill mix of neonatal practitioners, nurses, and doctors. Likewise, the challenging circumstances in developing countries are taken into consideration. It is a legal requirement to advise users of the information provided within this publication that the editor and publisher are not responsible for any errors or omissions and or any consequences arising from the use of this book.

Hadi Practical Neonatology ,a 2-book series of practical guidelines, is intended to provide a structured approach to the management of neonatal conditions which are likely to face the neonatal team. It is not intended to replace textbooks or to teach the beginners in the field. Prior sound knowledge of Neonatal Medicine, by the user, is essential. This book is the first in the series. It covers aspects of RESUSCITATION, THERMAL CONTROL- RESPIRATORY-CARDIOVASCULAR-INFECTIONS- ENDOCRINE & METABOLIC-GASTROINTESTINAL & NUTRITION- DERMATOLOGY- and SURGICAL NEWBORN challenges. It is my belief that neonatal doctors and nurses are an integrated team, and any demarcation is an imaginary line. The recipe of creating a backbone of good nurses is passionate support, continuous education, and practical teaching at every possible opportunity. Mutual trust and appropriate delegations are crucial to the success of the team. HADI PN series is written for the neonatal team and not just for the medical staff. The best way for consolidating the team knowledge and experience is bedside teaching. New methods and approaches of neonatal management are progressing but seem to slow down over the last few years. This may reflect the fact neonatal advances are approaching our era peak of “what is possible.” Nevertheless, many of our current practices are yet to be scrutinized to fulfil the evidence-based standards. There is no robust verification of the evidence behind our current practice of many routine day to day applications. This include but not limited to fluid requirements, duration of antibiotics courses, use of various blood products, seizures pharmacological treatment, and safe PaCO2 levels. I have reviewed multiple medical and nursing guidelines from Europe, North America, and Australia as well as Asia, South America, and Africa. I integrated many of these guidelines within this book whenever they are in accord with the international acceptable practices. Feedback and suggestions are welcome and can be sent to [email protected] The book is an updated version of the protocols and guidelines which I have developed during my work as Consultant Neonatologist. Some are adopted from various reputable institutes and modified to reflect the current evidence plus a slight flavour of my experience. Considerable effort has been exercised to ensure the doses of medications given in HADI PN are accurate. However, further confirmation by the nursing and medical staff is advised prior to the first use of each medication. HADI PN reflects the author’s own acceptable and safe practice and advice. It is written with the intention of facilitating the delivery of care to the most vulnerable newborn. The publication is written bearing in mind the wide variations in the skill mix of neonatal practitioners, nurses, and doctors. Likewise, the chall

In collaboration with Consulting Editor, Dr. Lucky Jain, Drs. Hamrick and Ing have put together a comprehensive issue that provides current information of anesthesia, sedation, and pain control in the NICU and for mothers. Clinical review articles are devoted to the following topics: Anesthesia neurotoxicity in the developing brain: Basic studies; Anesthesia neurotoxicity: Update on clinical studies; Neurologic Injury after neonatal cardiac surgery; Effect of repetitive pain on developing brain and physiology of nociception; Sedation/pain control in the NICU; Assessment of Pain in the Newborn; Non-pharmacologic Approaches to Pain Management; Epidurals/spinals for newborn surgery; Neonatal airway management; Effects of maternal anesthesia on perinatal hemodynamics and neonatal acidemia; Maternal anesthesia for urgent c-section; Fetal anesthesia; Neonatal abstinence syndrome (Neonatal Opioid Withdrawal Syndrome); and Opioid crisis in the US: Maternal management. Readers will come away with the information they need to provide better care to the neonate and mothers and improve outcomes.

Together with Consulting Editor Dr. Lucky Jain, Dr. Sudarshan R. Jadcherla has put together a comprehensive issue devoted to neonatal gastroenterology. Expert authors have contributed clinical review articles on the following topics: Neonatal Aerodigestive Disorders: Epidemiology and Economic Burden; Feeding and Swallowing Difficulties in Neonates: Developmental Physiology and Pathophysiology; Gastroesophageal Reflux Disease in the NICU Neonate: Controversies, Current Understanding and Future Directions; Feeding Difficulties and Tube-feeding Controversies in Complex Neonates: Evidence-Based Practices; Physiology and Pathological basis of Aerodigestive Difficulties in Chronic Lung Disease; Congenital Diarrheas in Infants: Pathophysiology, Consequences, and Potential Treatment Strategies; Short Gut syndrome: Recent Advances in Pathophysiology and Intestinal Support Practices; Neonatal Cholestasis in the Premature Infant: Approaches to Diagnosis and Management; Strategies for Prevention of TPN-related Liver Injury; Supplements and Additives to Human Milk: Principles and Practices, Current Controversies; Microbiome and Gut Injury in Neonates; Recent Advances in NEC Research: Strategies for Implementation in Clinical Practice; Transfusion-Related Gut Injury and NEC; Neonatal Endoscopy, Diagnosis and Intervention Procedures Crib-side; and Surgical Gastrointestinal Emergencies in Neonates: An overview. Readers will come away with the information they need to improve outcomes in the neonate.