Negative Affective States and Cognitive Impairments in Nicotine Dependence is the only book of its kind that addresses nicotine use and abuse in the context of negative reinforcement mechanisms. Written and edited by leading investigators in addiction, affective, genetic, and cognitive research, it provides researchers and advanced students with an overview of the clinical bases of these effects, allowing them to fully understand the various underlying dysfunctions that drive nicotine use in different individuals. In addition, this book examines animal models that researchers have utilized to investigate the biological bases of these dysfunctions. The combination of clinical and preclinical approaches to understanding nicotine dependence makes this book an invaluable resource for researchers and practitioners seeking to develop targeted treatments aimed at ameliorating symptoms of nicotine dependence, as well as identifying premorbid differences in affective or cognitive function. - Provides a unique perspective on nicotine dependence that emphasizes negative reinforcement rather than positive reinforcement - Examines psychiatric comorbidities and alleviation of withdrawal states as motivation for continued tobacco use - Includes both clinical and preclinical perspectives - Includes genetic and multi-neurotransmitter perspectives on nicotine use and withdrawal - Emphasizes heterogeneity of underlying reasons for smoking, the need for multiple animal models to understand this heterogeneity, and the expectation of heterogeneous responses to potential treatments, underscoring the need for personalized therapeutics

This booklet for schools, medical personnel, and parents contains highlights from the 2012 Surgeon General's report on tobacco use among youth and teens (ages 12 through 17) and young adults (ages 18 through 25). The report details the causes and the consequences of tobacco use among youth and young adults by focusing on the social, environmental, advertising, and marketing influences that encourage youth and young adults to initiate and sustain tobacco use. This is the first time tobacco data on young adults as a discrete population have been explored in detail. The report also highlights successful strategies to prevent young people from using tobacco.

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

The book includes an examination of sources of law important to addiction and its treatment. The foundations for forensic work in professional legal testimony is explored (e.g., legal system, case law precedent, statutes governing addictions, civil and criminal procedures). The science of addiction is featured including the biology of addiction, addiction as a brain disease, responsibility vs. loss of control, development of addictions, and the role of genetics and environment. Drug testing, its uses with forensic populations, what the tests show and do not show, controversies in using tests in the general population also receives extensive treatment. Addiction and mental illness in forensic populations is highlighted for addiction treatment and continuing care. Case studies and landmark cases illustrate the role of alcohol, drug use, and addictions in legal decisions. - Focused primarily on alcohol and drug addictions - Case studies and landmark cases are included to illustrate the role of alcohol/drugs in legal decisions (e.g., the Exxon Valdez case) - Brief overview of legal system and drug courts will be useful to clinicans, lawyers, administrators, and other professionals

Anhedonia is a key symptom (and often risk factor) for various neuropsychiatric disorders, including depression, schizophrenia, substance use disorders, post-traumatic stress disorders, and Parkinson's Disease, among others. Across disorders, anhedonia has been associated with worse disease course, including poor response to pharmacological, psychological and neurostimulation treatments as well as completed suicide. Mounting evidence emerging from preclinical and translational sciences has clarified that "anhedonia" can be parsed into partially independent subcomponents, including incentive motivation, consummatory pleasure, reward learning, and effort-based decision making, pointing to distinct neurobiological substrates that could underlie anhedonic phenotypes. Taking an integrative approach that emphasizes cross-species integration and dimensional conceptualization of mental illnesses (e.g., Research Domain Criteria (RDoC)), this book represents the most comprehensive evaluation, synthesis and integration of theories and empirical findings focused on anhedonia. Organized across five parts, the handbook starts with chapters on the history, etiology, and assessments of anhedonia (Part I), followed by a section on the role of anhedonia in psychiatric and neurological disorders (Part II). Using the RDoC Matrix as a guide, Part III presents chapters synthetizing preclinical and clinical findings on different reward processing subdomains (e.g., reward responsiveness, reward valuation, reward learning). Part IV is focused on selected special topics, including historical and current perspectives on the transdiagnostic nature and importance of social anhedonia, the role of inflammation in the pathophysiology of anhedonia, the use of computational modeling to “dissect” anhedonia and improve its understanding, and links between anhedonia and suicide. Finally, Part V includes chapters on pharmacological, psychological and neurostimulation treatments for anhedonia.

This work offers an evaluation of competing theoretical perspectives and nosological systems for personality disorders. The editors have brought together recognized authorities in the field to offer a synthesis of competing perspectives that provide readers with an assessment for each disorder. The result is a comprehensive, current, and critical summary of research and practice guidelines related to the personality disorders. Key Features focuses on controversies and alternative conceptualizations; separate chapters are dedicated to each personality disorder and considered from various points of view. It presents authoritative perspectives; leading scholars and researchers in the field provide a critical evaluation of alternative perspectives on each personality disorder. And it frames the current state of personality disorder research and practice issues; cutting edge and streamlined research is presented to be used in courses on diagnosis, assessment, psychopathology and abnormal psychology, especially those that include the DSM IV. It also offers an integrative understanding of elusive personality categorizations; wherever possible, case examples are offered as illustrations of each disorders clinical presentation. The use of technical terms are minimized; each contributor takes the approach of a user friendly summary and integration of major trends, findings, and future directions.

Emotions are complex and multifaceted phenomena. Although they have been examined from a variety of perspectives, the study of the interaction between cognition and emotion has always occupied a unique position within emotion research. Many philosophers and psychologists have been fascinated by the relationship between thinking and feeling. During the past 30 years, research on the relationship between cognition and emotion has boomed and so many studies on this topic have been published that it is difficult to keep track of the evidence. This book fulfils the need for a review of the existing evidence on particular aspects of the interplay between cognition and emotion. The book assembles a collection of state-of-the-art reviews of the most important topics in cognition and emotion research: emotion theories, feeling and thinking, the perception of emotion, the expression of emotion, emotion regulation, emotion and memory, and emotion and attention. By bringing these reviews together, this book presents a unique overview of the knowledge that has been generated in the past decades about the many and complex ways in which cognition and emotion interact. As such, it provides a useful tool for both students and researchers alike, in the fields of social, clinical and cognitive psychology.

It is often suggested that the incidence of cancer and coronary heart disease could be much reduced or even eliminated if only people would stop smoking cigarettes and eat fewer high-cholesterol foods. The evidence, however, shows that such views are simplistic and unrealistic and that, instead, cancer and CHD are the product of many risk factors acting synergistically. Psychosocial factors (stress, personality) are six times as predictive as smoking, cholesterol level or blood pressure and much more responsive to prophylactic treatment. This book admits that, while smoking is a risk factor for cancer and CHD, its effects have been exaggerated. A more realistic appraisal of a very complex chain of events incorporating many diverse factors is given, and appropriate action to prevent cancer and coronary heart disease is discussed.