The book examines recent developments in regenerative medicine and the use of musculoskeletal ultrasound. Musculoskeletal regeneration has become a prominent research topic, no doubt due to the sociological and economic pressures imposed by the current ageing population. The ever expanding role of regenerative medicine and the identification as well as characterization of stem cells have introduced a major paradigm shift in the field of musculoskeletal and sports medicine as well as orthopaedic surgery. Whereas in the past, diseased tissue was replaced with allograft material, current trends in research revolve around regenerating damaged tissue. Specifically, regenerative medicine stands in contrast to the standard treatment modalities which impair the body’s natural abilities to facilitate endogenous repair mechanisms such as anti-inflammatory drugs; or destructive modalities (e.g., radiotherapy, nerve ablation, injections of botulinum toxin) and surgical interventions that permanently alter the functioning of a joint, bone or spine. When compared to other allopathic options (including knee and hip arthroplasty with a 90-day mortality rate of 0.7%), regenerative medicine treatment modalities have a lower incidence of adverse events with a growing body of statistically significant medical literature illustrating both their safety and efficacy. Focusing on the major values of regenerative medicine, this book with its 21 chapters is expected to fill an important void in the current literature. It will take that extra step to guide you in your day to day clinical practice. Featuring contributions from a large international group of leaders in regenerative medicine and musculoskeletal ultrasonography, this book is an authoritative reference for rheumatologists, physiatrists, sonographers, radiologists, physiotherapists and orthopaedic specialists.

This spectacular cross-sectional atlas provides a roadmap of normal sonographic anatomy of the musculoskeletal system with optimized images that emphasize spatial relationships and three-dimensional orientation. The book is designed to help novices acquire pattern recognition skills to resolve images into their anatomic components by pairing ultrasound scans with cross-sectional drawings. It will enhance familiarity with musculoskeletal anatomy as it appears on ultrasound imaging for practitioners at any level. Using a sectioned approach, the authors present a visual baseline for evaluating tendon, muscle, ligament, and nerve problems in the upper extremity, lower extremity, and cervical regions. Multiple high resolution views of each structure are accompanied by original illustrations that document the structures in the sonograph and serve as a reference to decipher the image and foster understanding of anatomic relationships and ultrasound appearances. The atlas is an indispensable tool for clinicians learning diagnostic ultrasound, as they can use the anatomical images for comparisons with their own scans. For the seasoned practitioner, the organized format with high-resolution examples makes this an essential reference for confirming exam findings. Key Features: Orients users to anatomical relationships best seen in cross section and necessary to effective utilization of diagnostic ultrasound Over 150 ultrasound images cover musculoskeletal anatomy from the shoulder to the foot Each ultrasound image has a correlative drawing in cross-sectional or regional format with the scanned area depicted within a highlighted frame to enhance understanding of the scanned anatomy. Each image is accompanied by a body icon illustrating the level of the scan for each region Brief text points and legends emphasize key features and landmarks and offer technical tips for obtaining and interpreting scans.

This contributed volume presents the current state of research on regenerative rehabilitation across a broad range of neuro- and musculoskeletal tissues. At its core, the primary goal of regenerative rehabilitation is to restore function after damage to bones, skeletal muscles, cartilage, ligaments/tendons, or tissues of the central and peripheral nervous systems. The authors describe the physiology of these neuro- and musculoskeletal tissue types and their inherent plasticity. The latter quality is what enables these tissues to adapt to mechanical and/or chemical cues to improve functional capacity. As a result, readers will learn how regenerative rehabilitation exploits that quality, to trigger positive changes in tissue function. Combining basic, translational, and clinical aspects of the topic, the book offers a valuable resource for both scientists and clinicians in the regenerative rehabilitation field.

Point-of care ultrasound, or ultrasound performed and interpreted by the clinical in the clinic/office or at the bedside, has been rapidly expanding in use among multiple medical specialties. Musculoskeletal ultrasound has added value to clinical care to expedite diagnoses by visualizing mechanical versus inflammatory features and correlating these findings with patient’s symptoms. The use of power Doppler to assess for subclinical inflammation or active hyperemia has been a distinguishing use of ultrasound for rheumatologists. Accurate needle guidance with ultrasound for joint and tendon procedures has allowed expansion of procedures in the clinic and has been associated with less pain and precise targeting of affected structures. Musculoskeletal ultrasound education is now offered in nearly all rheumatology fellowship training programs in the United States and is also included in residency training in other specialties (e.g. physical medicine and rehabilitation, orthopedics, podiatry, emergency medicine, and family medicine). Since the publication of the first edition of Musculoskeletal Ultrasound in Rheumatology Review, there has been tremendous growth of musculoskeletal ultrasound in the field of rheumatology as well as other musculoskeletal specialties. The expanded second edition of this practical guide provides an updated clinical review of diagnostic and interventional applications of musculoskeletal ultrasound in rheumatology. New and revised chapters focus on the use of ultrasound in the diagnosis of specific rheumatic diseases such as osteoarthritis, scleroderma, psoriatic arthritis, gout, and lupus. Each chapter covers a standardized protocol of joint images with probe placement and includes numerous examples of common ultrasound pathologies. Study tools such as key-concept overviews, lists of important studies in the field, and extensive questions for self-assessment are included throughout. Written by current experts and thought leaders in the rapidly advancing field of rheumatology ultrasound, the second edition of Musculoskeletal Ultrasound in Rheumatology Review is an essential reference for physicians and related professionals, residents, fellows, graduate students and nurses in rheumatology, imaging and radiology, sports medicine, internal medicine, and physiotherapy.

This is the first truly foundational, introductory text designed to help novice practitioners master the fundamentals of musculoskeletal ultrasound. For the new practitioner who has yet to hold a transducer, Dr. Strakowski makes beginning easy and presents detailed step-by-step instructions for operating the equipment, obtaining good images, and successfully interpreting sonograms. Organized for maximum learning value, the book is packed with high-quality color images, tables, and tips to enhance understanding of proper technique and proficiency in musculoskeletal ultrasound. This “quick start” manual provides a simplified approach to essential physics, terminology, instrumentation and image optimization, proper scanning technique, and ergonomics. It is also designed to instruct in the recognition of the normal sonographic appearance of muscle, nerves, and tendons; other tissue, foreign bodies, masses, and artifacts; and use in interventional procedures. The final chapter offers recommendations for getting started in practice. The book’s clear, concise presentation will help new practitioners, residents, and medical students take the first steps in using ultrasound in the musculoskeletal clinic with confidence and skill. Key Features: A concise, visual introduction to musculoskeletal ultrasound technical fundamentals, image acquisition, and interpretation Designed to help new practitioners get comfortable quickly with scanning technique and sonographic appearance of musculoskeletal tissue, artifacts, foreign bodies, and masses Covers the basics of ultrasound guidance for injections Packed with nearly 300 high-quality images and “Remember” boxes with clinical pearls

This book presents the evidence related to the use of injectable biologics to provide faster and better healing for musculoskeletal lesions and conditions. The authors discuss approaches, such as blood derivatives and cell concentrates, applied to lesions of muscles, ligaments, tendons, bones, meniscus and cartilage, as well as osteoarthritis. Chapters are written by some of the most influential opinion leaders in the field, with up-to-date review of the current literature, where the authors explore both the potential and the limitations of these minimally invasive and promising treatments. The first section is devoted to the formulations and rationale for the use of injectable orthobiologics, while the second section reviews current treatment methods applied to specific joints and pathologies – ranging from tendinopathies through non-unions to articular degenerative processes – as well as the results of these treatment approaches. The third section explores future perspectives, such as pluripotent stem cells, gene therapy, and the stimulation of intrinsic stromal cell niches. Appealing to a broad readership, this book will be of interest to both laboratory research scientists and clinicians, including orthopedists, sports physicians, physiatrists, and regenerative medicine experts.

Effectively perform and interpret musculoskeletal ultrasound with this concise, highly illustrated resource by Jon A. Jacobson, MD. Fully revised, this bestselling title covers all the essential details of musculoskeletal ultrasound imaging, providing a solid understanding of the technique and how to make accurate diagnoses. It takes a concise, clear, and step-by-step approach to all of the most common musculoskeletal ultrasound applications, with specific details on anatomy, patient positioning, scanning techniques, normal and abnormal findings, tips, and pitfalls. - A succinct, highly accessible writing style makes information easy to understand. - Common percutaneous ultrasound-guided musculoskeletal procedures are demonstrated, including transducer and needle positioning. - Reader-friendly lists, tables, and images make reference quick and easy. - Nearly 400 new ultrasound images show scanning technique, anatomy, and essential pathology. - Over 200 narrated video clips of real-time dynamic ultrasound imaging provide instruction in a succinct, didactic format, highlighting key findings. - Newly revised information throughout helps you grasp essential concepts in diagnostic musculoskeletal ultrasound, ultrasound-guided musculoskeletal procedures, and much more. - Chapter 1, Introduction and Chapter 2, Basic Pathology Concepts now included in both print and electronic versions. - Thoroughly revised text, references, and images keep you up to date. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices.

During the past decade, a wide range of scientific disciplines have adopted the use of adipose-derived stem/stromal cells (ASCs) as an important tool for research and discovery. In Adipose-Derived Stem Cells: Methods and Protocols, experts from the field, including members of the esteemed International Federation of Adipose Therapeutics and Science (IFATS), provide defined and established protocols in order to further codify the utilization of these powerful and accessible cells. With chapters organized around approaches spanning the discovery, pre-clinical, and clinical processes, much of the emphasis is placed on human ASC, while additional techniques involving small and large animal species are included. As a volume in the highly successful Methods in Molecular BiologyTM series, the detailed contributions include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Adipose-Derived Stem Cells: Methods and Protocols serves as a vital reference text for experienced researchers as well as new students on the path to further exploring the incredible potential of ASCs.

Featuring nearly 700 illustrations, images, and photos, Atlas of Musculoskeletal Ultrasound of the Extremities by Dr. Mohini Rawat is a comprehensive visual guide to musculoskeletal ultrasound imaging for health care students and clinicians. Musculoskeletal ultrasound imaging is a new, rapidly growing field with applications across many health care disciplines. With its increased popularity comes a need for detailed training resources. The Atlas of Musculoskeletal Ultrasound of the Extremities presents information on scanning protocols for the joint regions and peripheral nerves of the upper and lower extremities in an easy-to-follow, highly visual format. Beginning with an overview of ultrasound physics, equipment, terminology, and technique, the book provides detailed instruction for musculoskeletal ultrasound of the shoulder, elbow, wrist, hip, knee, ankle and foot, concluding with a comprehensive chapter on peripheral nerves. Each chapter contains detailed images of scanning protocols, anatomy, sonoanatomy, patient positioning, and probe positioning for each joint region. Images are accompanied by explanatory text descriptions, along with clinical pearls under points to remember. Designed for students and clinicians in physical therapy, occupational therapy, athletic training, orthopedics, rheumatology, physiatry and podiatry, the Atlas of Musculoskeletal Ultrasound of the Extremities provides essential introductory training materials and serves as a helpful reference for busy clinical environments.

This book focuses on mesenchymal stem cells (MSCs) of animal origin, including their isolation, characterization, and clinical applications. After briefly discussing the historical development of the field of stem cell research, it describes the basic properties and nature of stem cells particularly in relation to MSCs. In turn, it reviews materials and methods used to isolate MSCs from various sources, culture expansion, characterization and long-term storage. It also explores the therapeutic efficacy, immunomodulation and anti-inflammatory, and differentiation properties of MSCs. Importantly, the book discusses the applications of genetic engineering to enhance the efficacy and potential of MSCs in regenerative medicine. The book largely addresses the potential applications of mesenchymal stem cells in therapies for important species of domesticated animals including sheep, goats, cattle, buffalo, cats, dogs and horses. Finally, the book presents an abridgement of challenges and future prospects of stem cell research and application in medicine, in general and veterinary sciences, in particular.