This is the first book-length treatment of mathematical models of muscle functions. Although physiologists, biophysicists, and bioengineers often mention these models, particularly the important Huxley models, Thomas A. McMahon is the first completely to explain them.

The description for this book, Muscles, Reflexes, and Locomotion, will be forthcoming.

This book includes a valuable and extensive bibliography with historical introduction on pages 3-44. It is a detailed study of the physiology of skeletal muscle.

Edited and authored by a wealth of international experts in neuroscience and related disciplines, this key new resource aims to offer medical students and graduate researchers around the world a comprehensive introduction and overview of modern neuroscience. Neuroscience research is certain to prove a vital element in combating mental illness in its various incarnations, a strategic battleground in the future of medicine, as the prevalence of mental disorders is becoming better understood each year. Hundreds of millions of people worldwide are affected by mental, behavioral, neurological and substance use disorders. The World Health Organization estimated in 2002 that 154 million people globally suffer from depression and 25 million people from schizophrenia; 91 million people are affected by alcohol use disorders and 15 million by drug use disorders. A more recent WHO report shows that 50 million people suffer from epilepsy and 24 million from Alzheimer’s and other dementias. Because neuroscience takes the etiology of disease—the complex interplay between biological, psychological, and sociocultural factors—as its object of inquiry, it is increasingly valuable in understanding an array of medical conditions. A recent report by the United States’ Surgeon General cites several such diseases: schizophrenia, bipolar disorder, early-onset depression, autism, attention deficit/ hyperactivity disorder, anorexia nervosa, and panic disorder, among many others. Not only is this volume a boon to those wishing to understand the future of neuroscience, it also aims to encourage the initiation of neuroscience programs in developing countries, featuring as it does an appendix full of advice on how to develop such programs. With broad coverage of both basic science and clinical issues, comprising around 150 chapters from a diversity of international authors and including complementary video components, Neuroscience in the 21st Century in its second edition serves as a comprehensive resource to students and researchers alike.

R. B. Stein Department of Physiology, University of Alberta, Edmonton, Canada The impetus for this volume and the conference that gave rise to it was the feeling that studies on motor control had reached a turning point. In recent years, studies on motor units and muscle receptors have become increasingly detailed. Attempts to integrate these studies into quantitative models for the spinal control of posture have appeared and preliminary attempts have been made to include the most direct supraspinal pathways into these models (see for example the chapters by Nashner and Melvill Jones et al. in this volume). Thus, we felt that the time was ripe to summarize these developments in a way which might be useful not only to basic medical scientists, but also to clinicians dealing with disorders of motor control, and to bioengineers attempting to build devices to assist or replace normal control. Over the past few years, computer methods have also made possible increasingly detailed studies of mammalian locomotion, and improved physiological and pharmacological studies have appeared. There seems to be almost universal agreement now that the patterns for locomotion are generated in the spinal cord, and that they can be generated with little, if any, phasic sensory information (see chapters by Grillner and Miller et al. ). This concludes a long controversy on whether chains of reflexes or central circuits generate stepping patterns. The nature of the pattern generators in mammals remains obscure, but invertebrate studies on locomotion have recently made striking advances.

Humanoid Robotics provides a comprehensive compilation of developments in the conceptualization, design and development of humanoid robots and related technologies. Human beings have built the environment they occupy (living spaces, instruments and vehicles) to suit two-legged systems. Building systems, especially in robotics, that are compatible with the well-established, human-based surroundings and which could naturally interact with humans is an ultimate goal for all researches and engineers. Humanoid Robots are systems (i.e. robots) which mimic human behavior. Humanoids provide a platform to study the construction of systems that behave and interact like humans. A broad range of applications ranging from daily housework to complex medical surgery, deep ocean exploration, and other potentially dangerous tasks are possible using humanoids. In addition, the study of humanoid robotics provides a platform to understand the mechanisms and offers a physical visual of how humans interact, think, and react with the surroundings and how such behaviors could be reassembled and reconstructed. Currently, the most challenging issue with bipedal humanoids is to make them balance on two legs, The purportedly simple act of finding the best balance that enables easy walking, jumping and running requires some of the most sophisticated development of robotic systems- those that will ultimately mimic fully the diversity and dexterity of human beings. Other typical human-like interactions such as complex thought and conversations on the other hand, also pose barriers for the development of humanoids because we are yet to understand fully the way in which we humans interact with our environment and consequently to replicate this in humanoids.

Studies of human movement have proliferated in recent years, and there have been many studies of spinal pathways in humans, their role in movement, and their dysfunction in neurological disorders. This comprehensive reference surveys the literature related to the control of spinal cord circuits in human subjects, showing how they can be studied, their role in normal movement, and how they malfunction in disease states. Chapters are highly illustrated and consistently organised, reviewing, for each pathway, the experimental background, methodology, organisation and control, role during motor tasks, and changes in patients with CNS lesions. Each chapter concludes with a helpful resume that can be used independently of the main text to provide practical guidance for clinical studies. This will be essential reading for research workers and clinicians involved in the study, treatment and rehabilitation of movement disorders.