This edited work presents the most current evidence on osteosarcopenia from bench to bedside, which is expected to facilitate the understanding of this syndrome and to develop preventive and therapeutic strategies. With our aging population, chronic diseases such as osteoporosis and sarcopenia are becoming highly prevalent. Fortunately, our understanding of the bone and muscle interactions has increased in recent years. This has allowed to the coining of the term osteosarcopenia to describe a syndrome in which these two diseases overlap. This overlap between osteoporosis and sarcopenia has major negative effects not only on our older adults but also on health systems worldwide. Readers will find a highly translational approach that starts with a summary of recent discoveries on stem cells biology, muscle and bone interactions – including the role of local bone and muscle fat – followed by comprehensive reviews on myokines (i.e. myostatin), osteokines (i.e. osteocalcin) and adipokines (i.e. interleukins) as major players and determinants of bone and muscle loss with aging. In addition, the role of sex steroids (i.e. estrogens, androgens), and calciotropic hormones (i.e. parathyroid hormone, vitamin D) in the pathogenesis of this syndrome is also reviewed. Moreover, using practical diagnostic and therapeutic tips, this book summarizes the clinical characteristics of osteosarcopenic patients thus facilitating the diagnosis and treatment of this syndrome in clinical practice. Finally, the book presents the case for the Falls and Fractures Clinic as the optimal model of care for this syndrome, aimed to avoid fragmentation and optimize osteosarcopenia care, and simultaneously prevent falls and fractures in older persons. This book offers relevant information on the mechanisms of osteosarcopenia, and a practical guide on how to identify and treat this geriatric syndrome and its adverse outcomes, which are dramatically affecting our aging population. The work is written by leaders in the field and is especially suited not only to any researcher in the musculoskeletal arena but also to medical specialists and allied health professionals involved in the care of older persons.

You belong to me and I know it down deep, in muscle and bone, where my wolf lives. Avery Rhine isn't an average homicide detective with the Chicago PD. In fact, Avery isn't an average anything. Sure, as an omega he knows he's at the bottom of the food chain, but that's never slowed him down. He's got a great life, complete with a loving family and a best friend who'd take a bullet for him, so what more could he possibly want or need? Except, maybe, for the world to change. And to find someone to spend more than one night with, but that isn't high on his list of priorities. He's never been one to believe in destiny or whatever else the fantasies sell about there being someone special out there meant just for him. Then a chance encounter at a party changes everything. Graeme Davenport has no delusions about finding his true mate. The consensus is that if an alpha doesn't find their other half by the time they're thirty, the chances of it ever happening go from slim to none. He's not a mere alpha, though; Graeme is a cyne who sits at the pinnacle of lupine hierarchy, so he's obligated by tradition and duty to choose an omega now, sign a contract, and bond with him. Love is not part of the equation. When Graeme and Avery meet, their fierce attraction to each other flies in the face of reason and logic. Avery's intense physical reaction to the alpha is something he's never experienced before, while Graeme, who has always been the soul of discretion, loses all his inhibitions to desire for the man he wants to possess. They are two very different men trying to navigate expectations, separate reason from innate primal drive, and do it while working together to solve a murder. It will take everything they are to find a middle ground, and to learn to trust in a fated kind of love.

A clear, concise approach provides the anatomical information you need to excel in massage therapy! Know the Body: Muscle, Bone, and Palpation Essentials covers muscle identification plus attachments, actions, stabilization functions, nerve innervation, palpation, and treatment considerations for each of those muscles. Hundreds of full-color illustrations make it easier to learn muscle and bone identification, as well as bony landmarks. Written by expert massage therapy practitioner and educator Joseph E. Muscolino, Know the Body helps you learn — not simply memorize — the essentials of muscles, bones, and palpation. Winner of the 2012 Association of American Publishers PROSE Award, Nursing & Allied Health Sciences! - Full-color, overlay-style muscle illustrations show anatomical structures and include origin and insertion labeling. - An introductory overview includes chapters on terminology, the skeletal system, muscle function, and bone palpation. - Coverage of bones includes the bones and bony landmarks for each body region. - Review activities in muscle region chapters include short case studies highlighting common conditions related to specific muscles and review questions. - Treatment considerations explain how to apply muscle and palpation knowledge in massage practice. - An illustrated stretching atlas is included as the appendix. - A companion CD includes an interactive review of muscles.

This new work by a renowned massage author takes a close look at palpation of muscle and bone, and includes content related topics including trigger points with their pain referral patterns, stretching, and body mechanics. The DVD features video demonstrations of palpation of all muscles. Illustrations.

Examines the parts, organization, and development of the musculoskeletal system, including information on diseases and injuries of bones, muscles, and joints.

This first-ever Surgeon General's Report on bone health and osteoporosis illustrates the large burden that bone disease places on our Nation and its citizens. Like other chronic diseases that disproportionately affect the elderly, the prevalence of bone disease and fractures is projected to increase markedly as the population ages. If these predictions come true, bone disease and fractures will have a tremendous negative impact on the future well-being of Americans. But as this report makes clear, they need not come true: by working together we can change the picture of aging in America. Osteoporosis, fractures, and other chronic diseases no longer should be thought of as an inevitable part of growing old. By focusing on prevention and lifestyle changes, including physical activity and nutrition, as well as early diagnosis and appropriate treatment, Americans can avoid much of the damaging impact of bone disease and other chronic diseases. This Surgeon General's Report brings together for the first time the scientific evidence related to the prevention, assessment, diagnosis, and treatment of bone disease. More importantly, it provides a framework for moving forward. The report will be another effective tool in educating Americans about how they can promote bone health throughout their lives. This first-ever Surgeon General's Report on bone health and osteoporosis provides much needed information on bone health, an often overlooked aspect of physical health. This report follows in the tradition of previous Surgeon Generals' reports by identifying the relevant scientific data, rigorously evaluating and summarizing the evidence, and determining conclusions.

A version of the OpenStax text

This book provides an overview of skeletal biology from the molecular level to the organ level, including cellular control, interaction and response; adaptive responses to various external stimuli; the interaction of the skeletal system with other metabolic processes in the body; and the effect of various disease processes on the skeleton. The book also includes chapters that address how the skeleton can be evaluated through the use of various imaging technologies, biomechanical testing, histomorphometric analysis, and the use of genetically modified animal models. - Presents an in-depth overview of skeletal biology from the molecular to the organ level - Offers "refresher" level content for clinicians or researchers outside their areas of expertise - Boasts editors and many chapter authors from Indiana and Purdue Universities, two of the broadest and deepest programs in skeletal biology in the US; other chapter authors include clinician scientists from pharmaceutical companies that apply the basics of bone biology

The extremely potent substance botulinum neurotoxin (BoNT) has attracted much interest in diverse fields. Originally identified as cause for the rare but deadly disease botulism, military and terrorist intended to misuse this sophisticated molecule as biological weapon. This caused its classification as select agent category A by the Centers for Diseases Control and Prevention and the listing in the Biological and Toxin Weapons Convention. Later, the civilian use of BoNT as long acting peripheral muscle relaxant has turned this molecule into an indispensable pharmaceutical world wide with annual revenues >$1.5 billion. Also basic scientists value the botulinum neurotoxin as molecular tool for dissecting mechanisms of exocytosis. This book will cover the most recent molecular details of botulinum neurotoxin, its mechanism of action as well as its detection and application.