The “delightfully macabre” (The New York Times) true tale of a brilliant and eccentric surgeon…and his quest to transplant the human soul. In the early days of the Cold War, a spirit of desperate scientific rivalry birthed a different kind of space race: not the race to outer space that we all know, but a race to master the inner space of the human body. While surgeons on either side of the Iron Curtain competed to become the first to transplant organs like the kidney and heart, a young American neurosurgeon had an even more ambitious thought: Why not transplant the brain? Dr. Robert White was a friend to two popes and a founder of the Vatican’s Commission on Bioethics. He developed lifesaving neurosurgical techniques still used in hospitals today and was nominated for the Nobel Prize. But like Dr. Jekyll before him, Dr. White had another identity. In his lab, he was waging a battle against the limits of science and against mortality itself—working to perfect a surgery that would allow the soul to live on after the human body had died. This “fascinating” (The Wall Street Journal), “provocative” (The Washington Post) tale follows his decades-long quest into tangled matters of science, Cold War politics, and faith, revealing the complex (and often murky) ethics of experimentation and remarkable innovations that today save patients from certain death. It’s a “masterful” (Science) look at our greatest fears and our greatest hopes—and the long, strange journey from science fiction to science fact.

Death is something we all confront—it touches our families, our homes, our hearts. And yet we have grown used to denying its existence, treating it as an enemy to be beaten back with medical advances.We are living at a unique point in human history. People are living longer than ever, yet the longer we live, the more taboo and alien our mortality becomes. Yet we, and our loved ones, still remain mortal. People today still struggle with this fact, as we have done throughout our entire history. What led us to this point? What drove us to sanitize death and make it foreign and unfamiliar?Schillace shows how talking about death, and the rituals associated with it, can help provide answers. It also brings us closer together—conversation and community are just as important for living as for dying. Some of the stories are strikingly unfamiliar; others are far more familiar than you might suppose. But all reveal much about the present—and about ourselves.

"In short, Life Is Simple is enthralling."--Michael Blastland, Prospect A biologist argues that simplicity is the guiding principle of the universe Centuries ago, the principle of Ockham’s razor changed our world by showing simpler answers to be preferable and more often true. In Life Is Simple, scientist Johnjoe McFadden traces centuries of discoveries, taking us from a geocentric cosmos to quantum mechanics and DNA, arguing that simplicity has revealed profound answers to the greatest mysteries. This is no coincidence. From the laws that keep a ball in motion to those that govern evolution, simplicity, he claims, has shaped the universe itself. And in McFadden’s view, life could only have emerged by embracing maximal simplicity, making the fundamental law of the universe a cosmic form of natural selection that favors survival of the simplest. Recasting both the history of science and our universe’s origins, McFadden transforms our understanding of ourselves and our world.

The fascinating, curious, and sometimes macabre history of radium as seen in its uses in everyday life. Of all the radioactive elements discovered at the end of the nineteenth century, it was radium that became the focus of both public fascination and entrepreneurial zeal. Half Lives tells the fascinating, curious, sometimes macabre story of the element through its ascendance as a desirable item – a present for a queen, a prize in a treasure hunt, a glow-in- the-dark dance costume – to its role as a supposed cure-all in everyday twentieth-century life, when medical practitioners and business people (reputable and otherwise) devised ingenious ways of commodifying the new wonder element, and enthusiastic customers welcomed their radioactive wares into their homes. Lucy Jane Santos—herself the proud owner of a formidable collection of radium beauty treatments—delves into the stories of these products and details the gradual downfall and discredit of the radium industry through the eyes of the people who bought, sold and eventually came to fear the once-fetishized substance. Half Lives is a new history of radium as part of a unique examination of the interplay between science and popular culture.

With his stunning debut novel, She's Come Undone, Wally Lamb won the adulation of critics and readers with his mesmerizing tale of one woman's painful yet triumphant journey of self-discovery. Now, this brilliantly talented writer returns with I Know This Much Is True, a heartbreaking and poignant multigenerational saga of the reproductive bonds of destruction and the powerful force of forgiveness. A masterpiece that breathtakingly tells a story of alienation and connection, power and abuse, devastation and renewal--this novel is a contemporary retelling of an ancient Hindu myth. A proud king must confront his demons to achieve salvation. Change yourself, the myth instructs, and you will inhabit a renovated world. When you're the same brother of a schizophrenic identical twin, the tricky thing about saving yourself is the blood it leaves on your bands--the little inconvenience of the look-alike corpse at your feet. And if you're into both survival of the fittest and being your brother's keeper--if you've promised your dying mother--then say so long to sleep and hello to the middle of the night. Grab a book or a beer. Get used to Letterman's gap-toothed smile of the absurd, or the view of the bedroom ceiling, or the influence of random selection. Take it from a godless insomniac. Take it from the uncrazy twin--the guy who beat the biochemical rap. Dominick Birdsey's entire life has been compromised and constricted by anger and fear, by the paranoid schizophrenic twin brother he both deeply loves and resents, and by the past they shared with their adoptive father, Ray, a spit-and-polish ex-Navy man (the five-foot-six-inch sleeping giant who snoozed upstairs weekdays in the spare room and built submarines at night), and their long-suffering mother, Concettina, a timid woman with a harelip that made her shy and self-conscious: She holds a loose fist to her face to cover her defective mouth--her perpetual apology to the world for a birth defect over which she'd had no control. Born in the waning moments of 1949 and the opening minutes of 1950, the twins are physical mirror images who grow into separate yet connected entities: the seemingly strong and protective yet fearful Dominick, his mother's watchful "monkey"; and the seemingly weak and sweet yet noble Thomas, his mother's gentle "bunny." From childhood, Dominick fights for both separation and wholeness--and ultimately self-protection--in a house of fear dominated by Ray, a bully who abuses his power over these stepsons whose biological father is a mystery. I was still afraid of his anger but saw how he punished weakness--pounced on it. Out of self-preservation I hid my fear, Dominick confesses. As for Thomas, he just never knew how to play defense. He just didn't get it. But Dominick's talent for survival comes at an enormous cost, including the breakup of his marriage to the warm, beautiful Dessa, whom he still loves. And it will be put to the ultimate test when Thomas, a Bible-spouting zealot, commits an unthinkable act that threatens the tenuous balance of both his and Dominick's lives. To save himself, Dominick must confront not only the pain of his past but the dark secrets he has locked deep within himself, and the sins of his ancestors--a quest that will lead him beyond the confines of his blue-collar New England town to the volcanic foothills of Sicily 's Mount Etna, where his ambitious and vengefully proud grandfather and a namesake Domenico Tempesta, the sostegno del famiglia, was born. Each of the stories Ma told us about Papa reinforced the message that he was the boss, that he ruled the roost, that what he said went. Searching for answers, Dominick turns to the whispers of the dead, to the pages of his grandfather's handwritten memoir, The History of Domenico Onofrio Tempesta, a Great Man from Humble Beginnings. Rendered with touches of magic realism, Domenico's fablelike tale--in which monkeys enchant and religious statues weep--becomes the old man's confession--an unwitting legacy of contrition that reveals the truth's of Domenico's life, Dominick learns that power, wrongly used, defeats the oppressor as well as the oppressed, and now, picking through the humble shards of his deconstructed life, he will search for the courage and love to forgive, to expiate his and his ancestors' transgressions, and finally to rebuild himself beyond the haunted shadow of his twin. Set against the vivid panoply of twentieth-century America and filled with richly drawn, memorable characters, this deeply moving and thoroughly satisfying novel brings to light humanity's deepest needs and fears, our aloneness, our desire for love and acceptance, our struggle to survive at all costs. Joyous, mystical, and exquisitely written, I Know This Much Is True is an extraordinary reading experience that will leave no reader untouched.

From a New York Times bestselling author comes the gripping, untold history of science's darkest secrets, "a fascinating book [that] deserves a wide audience" (Publishers Weekly, starred review). Science is a force for good in the world—at least usually. But sometimes, when obsession gets the better of scientists, they twist a noble pursuit into something sinister. Under this spell, knowledge isn’t everything, it’s the only thing—no matter the cost. Bestselling author Sam Kean tells the true story of what happens when unfettered ambition pushes otherwise rational men and women to cross the line in the name of science, trampling ethical boundaries and often committing crimes in the process. The Icepick Surgeon masterfully guides the reader across two thousand years of history, beginning with Cleopatra’s dark deeds in ancient Egypt. The book reveals the origins of much of modern science in the transatlantic slave trade of the 1700s, as well as Thomas Edison’s mercenary support of the electric chair and the warped logic of the spies who infiltrated the Manhattan Project. But the sins of science aren’t all safely buried in the past. Many of them, Kean reminds us, still affect us today. We can draw direct lines from the medical abuses of Tuskegee and Nazi Germany to current vaccine hesitancy, and connect icepick lobotomies from the 1950s to the contemporary failings of mental-health care. Kean even takes us into the future, when advanced computers and genetic engineering could unleash whole new ways to do one another wrong. Unflinching, and exhilarating to the last page, The Icepick Surgeon fuses the drama of scientific discovery with the illicit thrill of a true-crime tale. With his trademark wit and precision, Kean shows that, while science has done more good than harm in the world, rogue scientists do exist, and when we sacrifice morals for progress, we often end up with neither.

A groundbreaking history of the human mind told through our experience of dreams—from the earliest accounts to current scientific findings—and their essential role in the formation of who we are and the world we have made. "A resounding case for the mystery, beauty and cognitive importance of dreams." —The New York Times What is a dream? Why do we dream? How do our bodies and minds use them? These questions are the starting point for this unprecedented study of the role and significance of this phenomenon. An inves­tigation on a grand scale, it encompasses literature, anthropology, religion, and science, articulating the essential place dreams occupy in human culture and how they functioned as the catalyst that compelled us to transform our earthly habitat into a human world. From the earliest cave paintings—where Sidarta Ribeiro locates a key to humankind’s first dreams and how they contributed to our capacity to perceive past and future and our ability to conceive of the existence of souls and spirits—to today’s cutting-edge scientific research, Ribeiro arrives at revolutionary conclusions about the role of dreams in human existence and evolution. He explores the advances that contempo­rary neuroscience, biochemistry, and psychology have made into the connections between sleep, dreams, and learning. He explains what dreams have taught us about the neural basis of memory and the transfor­mation of memory in recall. And he makes clear that the earliest insight into dreams as oracular has been elucidated by contemporary research. Accessible, authoritative, and fascinating, The Oracle of Night gives us a wholly new way to under­stand this most basic of human experiences.

What happens if the blood runs out? Twin Rivers Hospital has a new executive director, and he has eyes on research money. How better to get it than to exploit Jake's unusual condition? In terror of becoming a lab rat-or worse, having the blood supply cut off-Jake faces more tests (and needles). But he's got bigger problems than Dr. Malloy. Hearing heartbeats, feeling the gnaw of hunger, and fighting uncontrollable fangs, Jake starts to worry he might be the monster he always thought he wasn't. Where is the line between victim and villain? Between disease and desire? Between epilemic-and vampire?

In the spring of 1880, a group of American cowboys joined by a band of cossacks trek across the siberian wilderness to deliver cattle to a starving town.