First multi-year cumulation covers six years: 1965-70.

Monoclonal antibodies are one of the most exciting developments in biotechnology in recent years; this book provides a comprehensive description of principles, methodologies and applications of this powerful technology to modern science and industry.

The advent of hybridoma technology leading to the successful produc tion of monoclonal antibodies against a variety of tumor-associated antigens has, during the last decade, provided a very powerful tool for research and clinical investigations. These highly specific reagents have essentially replaced the polysera of the earlier days. The successful demonstration of the many wide ranging capabilities of the monoclonal antibody technique has already begun to exert an enormous impact on diverse areas of research in basic science and medicine. In particular, the potential of monoclonal antibodies to serve as carriers for selective targeting of radionuclides to tumors for diagnosis or therapy, has stimulated an intense surge of research interest and even revived hopes of realizing Ehrlich's concept of the "magic bullet". Indeed, the technology appears to be on the threshold of a revolution in diagnosing and treating malignant disease. Much work remains to be done, however, and even though the progress has been impressive, results to date have shown only moderate success. There is no question that the limited success we have achieved thus far is merely a prelude to the many more exciting developments yet to come.

The advent of biotechnology has the potential to develop a variety of novel or better quality products for the treatment of a large number of diseases in livestock. In addition, as we understand more about the reproductive physiology of animals, the potential exists to dramatically increase the productivity of animals through better therapeutics and diagnostics for the control of many infectious diseases. Productivity can also be increased through animal breeding strategies including gene transfer, micromanipulation of embryos and gamete sex selection. As well as being a valuable reference to current knowledge in these areas, this first supplement to Comprehensive Biotechnology also looks at societal concerns over the use of antibiotics and chemical residues in meat and milk products, which are forcing biotechnologists to investigate more natural means of controlling infection by stimulating the animal's own immune system to combat infection. The identification of a variety of cytokines which are involved in regulating immune responses provides opportunities to use the animal's natural defence mechanisms to combat many infections or increase the animal's resistance to such infections. These approaches should provide tools for eventual elimination of specific diseases from counties, regions or whole continents.

Upon contemplating an updated version of the 1974 edition of this book and envisioning its possible organization, it immediately became evident that the new version could no longer be written by one, two, or even three authors. The field has experienced an explosive expansion in various directions, and the wealth of newer data which has been accumulated over the last decade can hardly be presented by a single author in a critical and coherent manner. On the other hand, it appears worthwhile not to abandon the attempt to come foreward with a review which describes as comprehensively as possible the progress and the state of knowledge. It is the aim of this volume to present a general and comprehensive review on complement. It is intended not only for individuals working in this area, but also for those who are less familiar with the field. Several chapters in the book describe state-of-the-art experimental methods which are helpful to critically evaluate the experimental data. Simultaneously, they may provide the necessary technical tools for those who wish to enter this highly provocative and exciting field.

Human Polyomaviruses Molecular and Clinical perspectives Edited by Kamel Khalili and Gerald L. Stoner Our understanding of human polyomaviruses has evolved profoundly in the last fifteen years, creating an urgent need for an updated resource. Drs. Khalili and Stoner have collected the contributions of renowned researchers and clinicians in this cutting-edge volume. Human Polyomaviruses: Molecular and Clinical Perspectives presents in-depth analyses, comprehensive reviews, and timely assessments of recent discoveries and ongoing controversies focused on these important viral pathogens. Beginning with an historical perspective, this book covers up-to-date investigations into the molecular biology and pathogenesis of human polyomaviruses. All aspects of these persistent infections are subsequently covered, including clinical issues, from diagnosis to information on treatment and drug trials. Central topics are: BK virus JC virus Simian virus 40 (SV40) and its potential as a human pathogen Progressive multifocal leukoencephalopathy (PML) This reference is a superb indoctrination for graduate students, medical students, high-level undergraduates, and anyone engaged in the study of DNA viruses and their molecular biology, evolution, transmission, and pathological potential.