Molecular Themes in DNA Replication

Molecular Themes in DNA Replication
Author :
Publisher : Royal Society of Chemistry
Total Pages : 467
Release :
ISBN-10 : 9780854041640
ISBN-13 : 0854041648
Rating : 4/5 (40 Downloads)

Synopsis Molecular Themes in DNA Replication by : Lynne Suzanne Cox

Written by leading experts, this learned but accessible book highlights the latest work on eukaryotic DNA replication.

Molecular Themes in DNA Replication

Molecular Themes in DNA Replication
Author :
Publisher : Royal Society of Chemistry
Total Pages : 467
Release :
ISBN-10 : 9781847559852
ISBN-13 : 1847559859
Rating : 4/5 (52 Downloads)

Synopsis Molecular Themes in DNA Replication by : Lynne S Cox

DNA replication, the process of copying one double stranded DNA molecule to form two identical copies, is highly conserved at the mechanistic level across evolution. Interesting in its own right as a fascinating feat of biochemical regulation and coordination, DNA replication is at the heart of modern advances in molecular biology. An understanding of the process at both the biological and chemical level is essential to developing new techniques in molecular biology. Insights into the process at the molecular level provide opportunities to modulate and intervene in replication. Rapidly dividing cells need to replicate their DNA prior to division, and targeting components of the replication process is a potentially powerful strategy in cancer treatment. Conversely, ageing may be associated with loss of replication activity and restoring it to cells may moderate some of the diseases associated with old age. Replication is, therefore, fundamental to a huge range of molecular biological and biochemical applications, and provides many potential targets for drug design. The fast pace of replication research, particularly in providing new structural insights, has outdated the majority of available texts. This learned, yet accessible, book contains the latest research written by those conducting it. It examines conserved themes providing a biological background for biochemical, chemical and pharmaceutical studies of this huge and exciting field. Rather than simply "itemising" the replication steps and the proteins involved, replication is tackled from a novel perspective. The book provides logical groupings of processes based upon biochemical similarities. The emphasis on mechanisms and the relationship between structure and function targets the chapters towards biochemists and biological chemists as well as molecular and cell biologists. The book highlights new insights into the replication process, from the assembly of pre-replication complexes, through polymerisation mechanisms, to considering replication in the context of chromatin and chromosomes. It also covers mitochondrial DNA replication, and includes archaeal paradigms, which are proving increasingly relevant to the study of replication in higher eukaryotes. Exciting potential drug targets in DNA replication are discussed, particularly in the context of treating malaria and cancer.

The Mechanisms of DNA Replication

The Mechanisms of DNA Replication
Author :
Publisher : BoD – Books on Demand
Total Pages : 502
Release :
ISBN-10 : 9789535109914
ISBN-13 : 953510991X
Rating : 4/5 (14 Downloads)

Synopsis The Mechanisms of DNA Replication by : David Stuart

DNA replication is a fundamental part of the life cycle of all organisms. Not surprisingly many aspects of this process display profound conservation across organisms in all domains of life. The chapters in this volume outline and review the current state of knowledge on several key aspects of the DNA replication process. This is a critical process in both normal growth and development and in relation to a broad variety of pathological conditions including cancer. The reader will be provided with new insights into the initiation, regulation, and progression of DNA replication as well as a collection of thought provoking questions and summaries to direct future investigations.

Concepts of Biology

Concepts of Biology
Author :
Publisher :
Total Pages : 0
Release :
ISBN-10 : 1739015509
ISBN-13 : 9781739015503
Rating : 4/5 (09 Downloads)

Synopsis Concepts of Biology by : Samantha Fowler

Black & white print. Concepts of Biology is designed for the typical introductory biology course for nonmajors, covering standard scope and sequence requirements. The text includes interesting applications and conveys the major themes of biology, with content that is meaningful and easy to understand. The book is designed to demonstrate biology concepts and to promote scientific literacy.

Principles of Molecular Biology

Principles of Molecular Biology
Author :
Publisher : Jones & Bartlett Publishers
Total Pages : 781
Release :
ISBN-10 : 9781449647919
ISBN-13 : 144964791X
Rating : 4/5 (19 Downloads)

Synopsis Principles of Molecular Biology by : Burton E. Tropp

Includes access to the Student Companion Website with every print copy of the text.Written for the more concise course, Principles of Molecular Biology is modeled after Burton Tropp's successful Molecular Biology: Genes to Proteins and is appropriate for the sophomore level course. The author begins with an introduction to molecular biology, discussing what it is and how it relates to applications in "real life" with examples pulled from medicine and industry. An overview of protein structure and function follows, and from there the text covers the various roles of technology in elucidating the central concepts of molecular biology, from both a historical and contemporary perspective. Tropp then delves into the heart of the book with chapters focused on chromosomes, genetics, replication, DNA damage and repair, recombination, transposition, transcription, and wraps up with translation.Key Features:- Presents molecular biology from a biochemical perspective, utilizing model systems, as they best describe the processes being discussed-Special Topic boxes throughout focus on applications in medicine and technology-Presents "real world" applications of molecular biology that are necessary for students continuing on to medical school or the biotech industry-An end-of-chapter study guide includes questions for review and discussion-Difficult or complicated concepts are called-out in boxes to further explain and simplify

Molecular Biology

Molecular Biology
Author :
Publisher : Jones & Bartlett Publishers
Total Pages : 1137
Release :
ISBN-10 : 9780763786632
ISBN-13 : 0763786632
Rating : 4/5 (32 Downloads)

Synopsis Molecular Biology by : Burton E. Tropp

Newly revised and updated, the Fourth Edition is a comprehensive guide through the basic molecular processes and genetic phenomena of both prokaryotic and eukaryotic cells. Written for the undergraduate and first year graduate students, the text has been updated with the latest data in the field. It incorporates a biochemical approach as well as a discovery approach that provides historical and experimental information within the context of the narrative.

Molecular Biology

Molecular Biology
Author :
Publisher : Taylor & Francis
Total Pages : 732
Release :
ISBN-10 : 9781000822922
ISBN-13 : 1000822923
Rating : 4/5 (22 Downloads)

Synopsis Molecular Biology by : Jordanka Zlatanova

Molecular Biology: Structure and Dynamics of Genomes and Proteomes second edition illustrates the essential principles behind the transmission and expression of genetic information at the level of DNA, RNA, and proteins. Emphasis is on the experimental basis of discovery and the most recent advances in the field while presenting a rigorous, yet still concise, summary of the structural mechanisms of molecular biology. Topics new to this edition include the CRISPR-Cas gene editing system, Coronaviruses – structure, genome, vaccine and drug development, and newly recognized mechanisms for transcription termination. The text is written for advanced undergraduate or graduate-level courses in molecular biology. Key Features · Highlights the experimental basis of important discoveries in molecular biology. · Thoroughly updated with new information on gene editing tools, viruses, and transcription mechanisms, termination and antisense. · Provides learning objectives for each chapter. · Includes a list of relevant videos from the Internet about the topics covered in the chapter.

The Evolution of Molecular Biology

The Evolution of Molecular Biology
Author :
Publisher : Academic Press
Total Pages : 244
Release :
ISBN-10 : 9780128129180
ISBN-13 : 0128129182
Rating : 4/5 (80 Downloads)

Synopsis The Evolution of Molecular Biology by : Kensal Van Holde

The Evolution of Molecular Biology: The Search for the Secrets of Life provides the historical knowledge behind techniques founded in molecular biology, also presenting an appreciation of how, and by whom, these discoveries were made. It deals with the evolution of intellectual concepts in the context of active research in an approachable language that accommodates readers from a variety of backgrounds. Each chapter contains a prologue and epilogue to create continuity and provide a complete framework of molecular biology. This foundational work also functions as a historical and conceptual supplement to many related courses in biochemistry, biology, chemistry, genetics and history of science. In addition, the book demonstrates how the roots of discovery and advances–and an individual's own research–have grown out of the history of the field, presenting a more complete understanding and context for scientific discovery. - Expands on the development of molecular biology from the convergence of two independent disciplines, biochemistry and genetics - Discusses the value of molecular biology in a variety of applications - Includes research ethics and the societal implications of research - Emphasizes the human aspects of research and the consequences of such advances to society

DNA Replication

DNA Replication
Author :
Publisher : BoD – Books on Demand
Total Pages : 712
Release :
ISBN-10 : 9789533075938
ISBN-13 : 9533075937
Rating : 4/5 (38 Downloads)

Synopsis DNA Replication by : Herve Seligmann

The study of DNA advanced human knowledge in a way comparable to the major theories in physics, surpassed only by discoveries such as fire or the number zero. However, it also created conceptual shortcuts, beliefs and misunderstandings that obscure the natural phenomena, hindering its better understanding. The deep conviction that no human knowledge is perfect, but only perfectible, should function as a fair safeguard against scientific dogmatism and enable open discussion. With this aim, this book will offer to its readers 30 chapters on current trends in the field of DNA replication. As several contributions in this book show, the study of DNA will continue for a while to be a leading front of scientific activities.

DNA Replication, Recombination, and Repair

DNA Replication, Recombination, and Repair
Author :
Publisher : Springer
Total Pages : 548
Release :
ISBN-10 : 9784431558736
ISBN-13 : 443155873X
Rating : 4/5 (36 Downloads)

Synopsis DNA Replication, Recombination, and Repair by : Fumio Hanaoka

This book is a comprehensive review of the detailed molecular mechanisms of and functional crosstalk among the replication, recombination, and repair of DNA (collectively called the "3Rs") and the related processes, with special consciousness of their biological and clinical consequences. The 3Rs are fundamental molecular mechanisms for organisms to maintain and sometimes intentionally alter genetic information. DNA replication, recombination, and repair, individually, have been important subjects of molecular biology since its emergence, but we have recently become aware that the 3Rs are actually much more intimately related to one another than we used to realize. Furthermore, the 3R research fields have been growing even more interdisciplinary, with better understanding of molecular mechanisms underlying other important processes, such as chromosome structures and functions, cell cycle and checkpoints, transcriptional and epigenetic regulation, and so on. This book comprises 7 parts and 21 chapters: Part 1 (Chapters 1–3), DNA Replication; Part 2 (Chapters 4–6), DNA Recombination; Part 3 (Chapters 7–9), DNA Repair; Part 4 (Chapters 10–13), Genome Instability and Mutagenesis; Part 5 (Chapters 14–15), Chromosome Dynamics and Functions; Part 6 (Chapters 16–18), Cell Cycle and Checkpoints; Part 7 (Chapters 19–21), Interplay with Transcription and Epigenetic Regulation. This volume should attract the great interest of graduate students, postdoctoral fellows, and senior scientists in broad research fields of basic molecular biology, not only the core 3Rs, but also the various related fields (chromosome, cell cycle, transcription, epigenetics, and similar areas). Additionally, researchers in neurological sciences, developmental biology, immunology, evolutionary biology, and many other fields will find this book valuable.