This updated issue of Clinics in Laboratory Medicine, edited by Martin H. Bluth, will focus on Molecular Pathology. Topics include, but are not limited to, The Impact of Molecular Pathology on the Practice of Pathology; Molecular pathology techniques; Clinical Implication of MicroRNAs in Molecular Pathology; Diagnostic Molecular Microbiology; Molecular Pathology in Transfusion Medicine; Molecular Diagnosis of Hematopoietic Neoplasms; Molecular Diagnostics in Colorectal Carcinoma; Molecular Diagnostics in the Neoplasms of Small Intestine and Appendix; Molecular Diagnostics in Esophageal and Gastric Neoplasms; Molecular Diagnostics in the Neoplasms of the Pancreas, Liver, Gall Bladder, and Extrahepatic Biliary Tract; Current Applications of Molecular Genetic Technologies to the Diagnosis and Treatment of Cutaneous Melanocytic Neoplasms; Breast Carcinoma; and Gynecologic Cancers.

In this issue of Clinics in Laboratory Medicine, guest editor Lauren L. Ritterhouse brings her considerable expertise to the topic of molecular pathology. Experts in the field cover topics such as molecular pathology of lung cancer, gliomas, prostate cancer, and more. - Contains 14 relevant topics including clinical utilization and designing a test menu; molecular alteration in pediatric solid tumors; pan-cancer molecular biomarkers; and more. - Provides in-depth clinical reviews on molecular pathology, offering actionable insights for practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Molecular pathology has significantly matured over the past decade to establish itself as a discipline in its own right. Patient diagnosis, prognosis, management and care have been influenced by molecular pathology testing algorithms on a global scale. Whether it pertains to carrier status of deleterious genes, diagnosis by molecular techniques, assessment of appropriate remission post treatment, parentage or forensics testing – molecular pathology continues to increase its presence and influence in the diagnostic laboratory armamentarium. Furthermore, intellectualization and proprietization of molecular pathology with respect to the discovery of new genes and or new techniques continues to pose new challenges of test ownership, legalities, liabilities, widespread acceptance and utility. This issue of Laboratory Clinics seeks to provide selective state of the art understanding of molecular pathology with respect to its relationship to key pathology disciplines as well as the current challenges and promise for the future.

This issue of the Clinics in Laboratory Medicine, edited by Dr. Anil Parwani, is a special issue is devoted to topics in Pathology Informatics. Topics include but are not limited to: Basics of Information Systems (Hardware, Software); Networks, Interfaces and Communications; Databases; Data Representation, Coding and Communication Standards; Laboratory Information Systems; Enhancing and Customizing Laboratory Information Systems; Laboratory Management and Operations; Specialized Laboratory Information Systems; Middleware and Laboratory Automation; Bar Coding and Tracking; Molecular Pathology Informatics; Pathology Informatics and Project Management; Digital Imaging; Telepathology; Healthcare Information Systems; Data Security and Reliability; Role of Informatics in Patient Safety and Quality Assurance; Role of Pathology Informatics in IT Leadership; Selection and Implementation of New Information Systems; Biomedical Informatics and Research Informatics; Training in Pathology Informatics; and more.

In this issue of Clinics in Laboratory Medicine, guest editor Dr. Linoj Samuel brings his considerable expertise to the topic of Point of Care Testing. Top experts discuss the challenges, techniques, and data collection for point of care and at-home testing options for COVID-19, fungal pathogens, and STDs in various demographics, among other key topics. - Contains 10 practice-oriented topics including point of care testing during the COVID-19 pandemic: challenges and pitfalls; will antigen testing remain relevant in point of care testing; the role of point of care testing in specific populations; lab at home: is at-home testing the new normal; point of care testing for sexually transmitted diseases; and more. - Provides in-depth clinical reviews on point of care testing, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

This issue of Clinics in Laboratory Medicine, edited by Drs. Julio Delgado and Eszter Lazar-Molnar, will focus on HLA and Disease. Topics include, but are not limited to, The potential impact of NGS in HLA and disease association studies, HLA typing by NGS, HLA Antibody Testing: Evolution and Challenges, Diversity of killer cell immunoglobulin-like receptors and disease, Technical Aspects of Crossmatching in Transplantation, HLA Markers in Celiac Disease, HLA Associations in Drug Hypersensitivity Reactions, HLA in BMT, Post-transplant monitoring, HLA epitope matching in transplantation, and Molecular Testing in Post-Transplant Monitoring.

In this issue of Clinics in Laboratory Medicine, guest editor Dr. Fei Dong brings his considerable expertise to the topic of Molecular Oncology Diagnostics. Top experts in the field review current practices in molecular oncology diagnostics, highlighting the rapid clinical adoption of next generation sequencing techniques. The articles address key laboratory considerations in the molecular testing of cancer specimens and the impact of advanced testing strategies on patient care. - Contains 15 practice-oriented topics including utility of single gene testing in cancer specimens; analytical principles of cancer next generation sequencing; principles and validation of bioinformatics pipelines for cancer next generation sequencing; panel sequencing for targeted therapy selection in solid tumors; and more. - Provides in-depth clinical reviews on molecular oncology diagnostics, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

This issue of Clinics in Laboratory Medicine, edited by Dr. Dan Milner, will focus on Global Health and Pathology. Topics include, but are not limited to: Clinical Laboratory Volunteerism, Pathologists Overseas; Anatomic Pathology Volunteerism; Funding Strategies in Research and Global Pathology; Diagnostics for Cancer and Health Systems building through pathology laboratories; Training the next pathologists in global health; Maximizing internet resources for improving pathology/lab medicine in LMICs; Pathology-based research in Africa; HIV and Cancer: Role of Pathology in success; Lymphoma and Pathology in Africa: Current approaches and future diagnostics; Laboratory Capacity as a tool for building health systems; Building Cross Country Networks for Laboratory Capacity and improvement; Lab accreditation; Practical success in Telepathology experiences in Africa; Pathology and WHO vision of the future of LMICs; Breast Cancer in LMICs: Why we need pathology and clinical trial capability to solve this challenge; Cytopathology in LMICs: why and how to integrate to capacitate healthcare; and Biorepositories and Data Cores for Research in Global Health.

In this issue of Clinics in Laboratory Medicine, guest editor Dr. Alexa J. Siddon brings her considerable expertise to the topic of Myelodysplastic Syndromes. Top experts in the field discuss the various aspects of rare myelodysplastic syndromes and its treatments, detection, and characteristics. Topics include molecular changes in myelodysplastic syndromes; MDS with mutated SF3B1; myeloid neoplasms with mutated TP53; mimics of myelodysplastic syndromes; myeloid neoplasms with germline predisposition; and more. - Contains 12 practice-oriented topics including premalignant clonal hematopoiesis (CHIP and CCUS); morphologic characteristics of MDS; acute leukemia arising from MDS; treatment considerations of MDS for pathologists; and more. - Provides in-depth clinical reviews on myelodysplastic syndromes, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

This issue of Clinics in Laboratory Medicine titled, "Conceptual Advances in Pathology" addresses the key factors impacting pathology and details the technology surrounding the field. The Guest Editor, Zoltan Oltvai, MD., splits the issue into three sections; Technological Advances, Process Advances, Educational and Practice Needs, and the Business of Pathology.