Molecular Basis Of Inherited Pancreatic Disorders
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Author |
: Markus M. Lerch |
Publisher |
: W B Saunders Company |
Total Pages |
: 240 |
Release |
: 2006 |
ISBN-10 |
: 1416038701 |
ISBN-13 |
: 9781416038702 |
Rating |
: 4/5 (01 Downloads) |
Synopsis Molecular Basis of Inherited Pancreatic Disorders by : Markus M. Lerch
Progress in understanding the genetic basis of pancreatic disorders has been very rapid in recent years. This issue updates the current knowledge on the molecular basis of pancreatic disorders affecting the endocrine and the exocrine portion of the organ. It is filled with practical information about the unusual as well as the common diseases of the pancreas, with a major focus on inherited forms of diabetes, pancreatitis, and cancer. Clinical and genetic aspects deal with early detection, phenotype-genotype correlation, and treatment. Also new experimental disease models in which the pathophysiology of the respective disorders has been studied are introduced to the reader. Together, this volume represents the most important and up to date information available on new aspects of pancreatic diseases
Author |
: Joel F. Habener |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 413 |
Release |
: 2012-12-06 |
ISBN-10 |
: 9781461516699 |
ISBN-13 |
: 1461516692 |
Rating |
: 4/5 (99 Downloads) |
Synopsis Molecular Basis of Pancreas Development and Function by : Joel F. Habener
Diabetes mellitus is rapidly increasing in prevalence throughout both developed and developing countries. The social and economic burden of this disease is estimated to cost 14 billion dollars worldwide. In the USA alone, 15 million individuals are diabetic, nearly half of them unaware of their condition. Complications of diabetes mellitus are the leading causes for blindness, limb amputation and chronic renal failure and kidney transplantation in industrialized countries. Further, diabetes mellitus per se and the metabolic derangement associated with diabetes are important risk factors for cardiovascular disease. Diabetes, as defined by an elevated fasting blood glucose level is presently subdivided in etiologically distinct groups. The most prevalent being type 2 (adult onset) diabetes characterized by insulin resistance and failure of the ~-cell to supply insulin in amounts sufficient to meet the body's needs. Type 1 (juvenile) diabetes, most commonly with an onset during childhood and adolescence, is caused by an auto-immune destruction of the pancreatic ~-cells. The causations of both type 1 and type 2 diabetes involve a combination of complex genetic traits and environmental influences. A third category are the mature onset diabetes of the young (MODY). This comparatively small group of patients (-10% of diabetes) presents relative early in life «30 years of age) compared to the more common late onset type 2 diabetes.
Author |
: |
Publisher |
: |
Total Pages |
: 1306 |
Release |
: 2001 |
ISBN-10 |
: UOM:39015053165190 |
ISBN-13 |
: |
Rating |
: 4/5 (90 Downloads) |
Synopsis The Metabolic & Molecular Bases of Inherited Disease by :
Author |
: William B. Coleman |
Publisher |
: Academic Press |
Total Pages |
: 805 |
Release |
: 2017-11-09 |
ISBN-10 |
: 9780128027875 |
ISBN-13 |
: 0128027878 |
Rating |
: 4/5 (75 Downloads) |
Synopsis Molecular Pathology by : William B. Coleman
As the molecular basis of human disease becomes better characterized, and the implications for understanding the molecular basis of disease becomes realized through improved diagnostics and treatment, Molecular Pathology, Second Edition stands out as the most comprehensive textbook where molecular mechanisms represent the focus. It is uniquely concerned with the molecular basis of major human diseases and disease processes, presented in the context of traditional pathology, with implications for translational molecular medicine. The Second Edition of Molecular Pathology has been thoroughly updated to reflect seven years of exponential changes in the fields of genetics, molecular, and cell biology which molecular pathology translates in the practice of molecular medicine. The textbook is intended to serve as a multi-use textbook that would be appropriate as a classroom teaching tool for biomedical graduate students, medical students, allied health students, and others (such as advanced undergraduates). Further, this textbook will be valuable for pathology residents and other postdoctoral fellows that desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school. In addition, this textbook is useful as a reference book for practicing basic scientists and physician scientists that perform disease-related basic science and translational research, who require a ready information resource on the molecular basis of various human diseases and disease states. - Explores the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease - Explains the practice of "molecular medicine and the translational aspects of molecular pathology - Teaches from the perspective of "integrative systems biology - Enhanced digital version included with purchase
Author |
: Thomas M. Gress |
Publisher |
: IOS Press |
Total Pages |
: 124 |
Release |
: 2000 |
ISBN-10 |
: 158603040X |
ISBN-13 |
: 9781586030407 |
Rating |
: 4/5 (0X Downloads) |
Synopsis Molecular Pathogenesis of Pancreatic Cancer by : Thomas M. Gress
This book was written to summarize the midterm meeting of the concerted action BMH4-CT98-3085 funded by the European Union in the context of the BIOMEDII programme. The objective of this concerted action (CA) is to generate a European network allowing to share expertise, technologies and resources to speed up the process of characterization of potential new disease genes in pancreatic cancer. The meeting in Barcelona in November 1999 was hosted by the group at the IMIM led by F.X. Real, and was scheduled to allow a midterm evaluation of the individual projects.
Author |
: |
Publisher |
: |
Total Pages |
: 0 |
Release |
: 2002 |
ISBN-10 |
: 0815332181 |
ISBN-13 |
: 9780815332183 |
Rating |
: 4/5 (81 Downloads) |
Synopsis Molecular Biology of the Cell by :
Author |
: William B. Coleman |
Publisher |
: Academic Press |
Total Pages |
: 636 |
Release |
: 2019-11-23 |
ISBN-10 |
: 9780128132586 |
ISBN-13 |
: 0128132582 |
Rating |
: 4/5 (86 Downloads) |
Synopsis Essential Concepts in Molecular Pathology by : William B. Coleman
Essential Concepts in Molecular Pathology, Second Edition, offers an introduction to molecular genetics and the "molecular" aspects of human disease. The book illustrates how pathologists harness their understanding of these entities to develop new diagnostics and treatments for various human diseases. This new edition offers pathology, genetics residents, and molecular pathology fellows an advanced understanding of the molecular mechanisms of disease that goes beyond what they learned in medical and graduate school. By bridging molecular concepts of pathogenesis to the clinical expression of disease in cell, tissue and organ, this fully updated, introductory reference provides the background necessary for an understanding of today's advances in pathology and medicine. - Explains the practice of "molecular medicine" and the translational aspects of molecular pathology, including molecular diagnostics, molecular assessment and personalized medicine - Orients non-pathologists on what pathologists look for and how they interpret their observational findings based on histopathology - Provides the reader with what is missing from most targeted introductions to pathology—the cell biology behind pathophysiology
Author |
: Roy E. Weiss |
Publisher |
: Academic Press |
Total Pages |
: 462 |
Release |
: 2015-10-09 |
ISBN-10 |
: 9780128011348 |
ISBN-13 |
: 0128011343 |
Rating |
: 4/5 (48 Downloads) |
Synopsis Genetic Diagnosis of Endocrine Disorders by : Roy E. Weiss
Genetic Diagnosis of Endocrine Disorders, Second Edition provides users with a comprehensive reference that is organized by endocrine grouping (i.e., thyroid, pancreas, parathyroid, pituitary, adrenal, and reproductive and bone), discussing the genetic and molecular basis for the diagnosis of various disorders. The book emphasizes the practical nature of diagnosing a disease, including which tests should be done for the diagnosis of diabetes mellitus in adults and children, which genes should be evaluated for subjects with congenital hypothyroidism, which genetic tests should be ordered in obese patients or for those with parathyroid carcinoma, and the rationale behind testing for multiple endocrine neoplasias. - Offers a clear presentations of pharmacogenetics and the actual assays used in detecting endocrine diseases - Teaches the essentials of the genetic basis of disease in each major endocrine organ system - Offers expert advice from genetic counselors on how to use genetic information in counseling patients - Includes new chapters on the genetics of lipid disorders and glycogen storage diseases, genetics of hypoglycemia, and whole genome/exome sequencing
Author |
: Chris E. Forsmark |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 340 |
Release |
: 2005 |
ISBN-10 |
: 9781588291790 |
ISBN-13 |
: 1588291790 |
Rating |
: 4/5 (90 Downloads) |
Synopsis Pancreatitis and Its Complications by : Chris E. Forsmark
World-renowned experts and opinion-makers comprehensively review the clinical challenges of managing acute and chronic pancreatitis and explain the basic science that underlies these management strategies. The authors provide up-to-date discussions of the pathophysiology, epidemiology, diagnostic strategies, treatment, and complications of the diseases.
Author |
: Juan Enrique Dominguez-Munoz |
Publisher |
: John Wiley & Sons |
Total Pages |
: 752 |
Release |
: 2021-03-17 |
ISBN-10 |
: 9781119570141 |
ISBN-13 |
: 111957014X |
Rating |
: 4/5 (41 Downloads) |
Synopsis Clinical Pancreatology for Practising Gastroenterologists and Surgeons by : Juan Enrique Dominguez-Munoz
Clinical Pancreatology Since the book Clinical Pancreatology for Practising Gastroenterologists and Surgeons was first published sixteen years ago, the knowledge and clinical management of pancreatic diseases have developed markedly. Thanks to the development of the translational research and the from bench to bedside concept, much progress from the lab has been applied to clinical practice. In addition, several highly relevant clinical trials published over the last years have resulted in the update and optimisation of clinical guidelines. A new and validated classification of severity and complications of acute pancreatitis is firmly rooted in clinical practice and has been the basis for the development of minimally invasive approaches to pancreatic necrosis. The etiopathogenic knowledge of chronic pancreatitis and other pancreatopaties, like that associated with diabetes mellitus, has developed significantly. Especially important has been the development of the field of cystic pancreatic tumours, which has been reflected in the publication of several guidelines and consensus reports over the last few years. Most research efforts have focused on pancreatic cancer, which have led and will further lead to a significant increase in the therapeutic armamentarium against this devastating disease. Finally, many newly published studies have changed the concept, causes, clinical relevance, diagnosis and treatment of exocrine pancreatic insufficiency. This new edition of Clinical Pancreatology for Practising Gastroenterologists and Surgeons has enjoyed the collaboration of the world’s leading experts in each of the areas of clinical pancreatology with the aim of facilitating gastroenterologists, surgeons, oncologists, internists, nutritionists, diabetologists, paediatricians, radiologists, pathologists and other specialists in their decision making when facing patients with pancreatic diseases in their daily clinical practice. All in all, this book supplies an indispensable update of the relevant aspects of clinical pancreatology.