This textbook takes you on a journey to the basic concepts of cancer biology. It combines developmental, evolutionary and cell biology perspectives, to then wrap-up with an integrated clinical approach. The book starts with an introductory chapter, looking at cancer in a nut shell. The subsequent chapters are detailed and the idea of cancer as a mass of somatic cells undergoing a micro-evolutionary Darwinian process is explored. Further, the main Hanahan and Weinberg “Hallmarks of Cancer” are revisited. In most chapters, the fundamental experiments that led to key concepts, connecting basic biology and biomedicine are highlighted. In the book’s closing section all of these concepts are integrated in clinical studies, where molecular diagnosis as well as the various classical and modern therapeutic strategies are addressed. The book is written in an easy-to-read language, like a one-on-one conversation between the writer and the reader, without compromising the scientific accuracy. Therefore, this book is suited not only for advanced undergraduates and master students but also for patients or curious lay people looking for a further understanding of this shattering disease

Demonstrating how the malfunction of normal molecular pathways and components can lead to cancer, this text explores how our understanding of these defective mechanisms can be harnessed to develop new targeted therapeutic agents.

Highlighting recent advances in our understanding of breast cancer, this book is intended for a wide audience as a reference book. Included are reviews of genetics, epigenetics, various aspects of cell and molecular biology, and several other areas of breast cancer that are aimed at determining new intervention sites for treatments and cures of the disease. The chapters are written by internationally recognized experts and include reviews of key topics in breast cancer research. Each chapter highlights the new aspects of specific research topics and the various impacts of designing new strategies as well as identifies new targets for therapeutic intervention. The topics addressed are selected to be of interest to patients, scientists, students, teachers, and anyone else interested in expanding their knowledge of breast cancer imaging, diagnostics, therapeutics, or basic biomedical research on breast cancer.

This title includes the following features: Great breadth of coverage inone volume: covers all aspects of cancer, in a concise and affordable format;Provides a comprehensive introduction to the initiation, development, andtreatment of cancer; Chapter are written by experts in each field, giving astate-of-the-art summary of each topic; Extensive references provide links toall the relevant literature, facilitating further study

Molecular Biology of Cancer has been extensively revised and covers heredity cancer, microarray technology and increased study of childhood cancers. It continues to provide a detailed overview of the process which lead to the development and proliferation of cancer cells, including the techniques available for their study. It also describes the means by which tumor suppressor genes and oncogenes may be used in the diagnosis and in determining the prognosis of a wide variety of cancers, including breast, genitourinary, lung and gastrointestinal cancer.

A concise overview of the fundamental concepts of cancer biology, ideal for those with little or no background in the field. From cancer epidemiology and the underlying mechanisms, through to tumour detection and treatment, the comprehensive picture revealed will enable students to move into the cancer field with confidence.

Incorporating the most important advances in the fast-growing field of cancer biology, the text maintains all of its hallmark features. It is admired by students, instructors, researchers, and clinicians around the world for its clear writing, extensive full-color art program, and numerous pedagogical features.

This volume covers classic and modern cell and molecular biology of prostate cancer, as well as novel biomarkers, inflammation, centrosome pathologies, microRNAs, cancer initiation novel biomarkers, inflammation, centrosome pathologies, microRNAs, cancer initiation and genetics, epigenetics, mitochondrial dysfunctions and apoptosis, cancer stem cells, angiogenesis and progression to metastasis, and treatment strategies including clinical trials related to prostate cancer. Cell & Molecular Biology of Prostate Cancer is one of two companion books comprehensively addressing the biology and clinical aspects of prostate cancer. Prostate Cancer: Molecular & Diagnostic Imaging and Treatment Stategies, the companion volume, discusses both classic and the most recent imaging approaches including analysis of needle biopsies, applications of nanoparticle probes and peptide-based radiopharmaceuticals for detection, early diagnosis and treatment of prostate cancer. Taken together, these volumes form one comprehensive and invaluable contribution to the literature.

The fourth edition of this classic text provides a thorough, yet concise review of the cellular and molecular mechanisms involved in the transformation of normal into malignant cells, the invasiveness of cancer cells into host tissues, and the metastatic spread of cancer cells in the host organism. It defines the fundamental pathophysiologic changes that occur in tumor tissue and in the host animal or patient. Each chapter discusses the historical development of a field, citing the key experimental advances to the present day, and evaluates the current evidence that best supports or rules out concepts of the molecular and cellular mechanisms regulating cancer cell behavior. For all the areas of fundamental cancer research, an effort has been made to relate basic research findings to the clinical disease states. The book is well written and well illustrated, with schematic diagrams and actual research data to demonstrate points made in the text. There is also an extensive, up-to-date bibliography, making the book valuable to scientists, and to physicians, students, and nurses interested in the field of cancer biology. The topics covered include pathologic characterization of human tumors, epidemiology of human cancer, regulation of cell proliferation and differentiation, cellular and molecular phenotypic characteristics of the cancer cell, mechanisms of carcinogenesis, tumor initiation and promotion, viral carcinogenesis, oncogenes and oncogene products, growth factors, chromosomal alterations in cancer, mechanisms of tumor metastasis, host-tumor interactions, fundamental aspects of tumor immunology, and the advances in cancer cell biology that will lead to improved diagnosis and treatment of cancer in the future.