In this candid and witty autobiography, Nobel laureate Herbert A. Simon looks at his distinguished and varied career, continually asking himself whether (and how) what he learned as a scientist helps to explain other aspects of his life. A brilliant polymath in an age of increasing specialization, Simon is one of those rare scholars whose work defines fields of inquiry. Crossing disciplinary lines in half a dozen fields, Simon's story encompasses an explosion in the information sciences, the transformation of psychology by the information-processing paradigm, and the use of computer simulation for modeling the behavior of highly complex systems. Simon's theory of bounded rationality led to a Nobel Prize in economics, and his work on building machines that think—based on the notion that human intelligence is the rule-governed manipulation of symbols—laid conceptual foundations for the new cognitive science. Subsequently, contrasting metaphors of the maze (Simon's view) and of the mind (neural nets) have dominated the artificial intelligence debate. There is also a warm account of his successful marriage and of an unconsummated love affair, letters to his children, columns, a short story, and political and personal intrigue in academe.

This book develops the mathematical tools essential for students in the life sciences to describe interacting systems and predict their behavior. From predator-prey populations in an ecosystem, to hormone regulation within the body, the natural world abounds in dynamical systems that affect us profoundly. Complex feedback relations and counter-intuitive responses are common in nature; this book develops the quantitative skills needed to explore these interactions. Differential equations are the natural mathematical tool for quantifying change, and are the driving force throughout this book. The use of Euler’s method makes nonlinear examples tractable and accessible to a broad spectrum of early-stage undergraduates, thus providing a practical alternative to the procedural approach of a traditional Calculus curriculum. Tools are developed within numerous, relevant examples, with an emphasis on the construction, evaluation, and interpretation of mathematical models throughout. Encountering these concepts in context, students learn not only quantitative techniques, but how to bridge between biological and mathematical ways of thinking. Examples range broadly, exploring the dynamics of neurons and the immune system, through to population dynamics and the Google PageRank algorithm. Each scenario relies only on an interest in the natural world; no biological expertise is assumed of student or instructor. Building on a single prerequisite of Precalculus, the book suits a two-quarter sequence for first or second year undergraduates, and meets the mathematical requirements of medical school entry. The later material provides opportunities for more advanced students in both mathematics and life sciences to revisit theoretical knowledge in a rich, real-world framework. In all cases, the focus is clear: how does the math help us understand the science?

From Revlon spokesmodel to film actress to one of People magazine's "50 Most Beautiful People," Karen Duffy was living the life most of us only dream of. Then her whirlwind life of celebrity parties came to an abrupt, grinding halt when she was stricken with a serious illness in one of its rarest forms: sarcoidosis of the central nervous system. Duffy soon realized that the only way for her to survive was not to take the disease too seriously. Instead of hiding from life, she chose to run toward it. She learned to embrace the chaos of a life-threatening disease with a wit and humor that helped her to find the love of her life at a time when things seemed darkest. Model Patient is a gripping, inspiring, and hilarious memoir that recounts the singular triumphs and tragedies of coping with a chronic, life-threatening disease.

An overview of current models of biological systems, reflecting the major advances that have been made over the past decade.

More than 300 years ago, Isaac Newton created a mathematical model of the solar system that predicted the existence of a yet unknown planet: Neptune. Today, driven by the digital revolution, modern scientists are creating complex models of society itself to shed light on topics as far-ranging as epidemic outbreaks and economic growth. But how do these scientists gather and interpret their data? How accurate are their models? Can we trust the numbers? With a rare background in physics, economics and sociology, the author is able to present an insider’s view of the strengths, weaknesses and dangers of transforming our lives into numbers. After reading this book, you’ll understand how different numerical models work and how they are used in practice. The author begins by exploring several simple, easy-to-understand models that form the basis for more complex simulations. What follows is an exploration of the myriad ways that models have come to describe and define our world, from epidemiology and climate change to urban planning and the world chess championship. Highly engaging and nontechnical, this book will appeal to any readers interested in understanding the links between data and society and how our lives are being increasingly captured in numbers.

This is a book about life modeling. Unlike the painter whose name appears beside his finished portrait, the life model, posing nude, perhaps for months, goes unacknowledged. Standing at a unique juncture—between nude and naked, between high and low culture, between art and pornography—the life model is admired in a finished sculpture, but scorned for her or his posing. Making use of extensive interviews with both male and female models and quoting them frequently, Sarah R. Phillips gives a voice to life models. She explores the meaning that life models give to themselves and to their work and seeks to understand the lived experience of life models as they practice their profession. Throughout history, people have romanticized life models in an aura of bohemian eroticism, or condemned them as strippers or sex workers. Modeling Life reveals how life models get into the business, managing sexuality in the studio, what it means to be a "muse," and why their work is important.

In the spring of 2010, Harvard Business School’s graduating class asked HBS professor Clay Christensen to address them—but not on how to apply his principles and thinking to their post-HBS careers. The students wanted to know how to apply his wisdom to their personal lives. He shared with them a set of guidelines that have helped him find meaning in his own life, which led to this now-classic article. Although Christensen’s thinking is rooted in his deep religious faith, these are strategies anyone can use. Since 1922, Harvard Business Review has been a leading source of breakthrough ideas in management practice. The Harvard Business Review Classics series now offers you the opportunity to make these seminal pieces a part of your permanent management library. Each highly readable volume contains a groundbreaking idea that continues to shape best practices and inspire countless managers around the world.

Essays that pay tribute to the wide-ranging influence of the late Herbert Simon, by friends and colleagues. Herbert Simon (1916-2001), in the course of a long and distinguished career in the social and behavioral sciences, made lasting contributions to many disciplines, including economics, psychology, computer science, and artificial intelligence. In 1978 he was awarded the Nobel Prize in economics for his research into the decision-making process within economic organizations. His well-known book The Sciences of the Artificial addresses the implications of the decision-making and problem-solving processes for the social sciences. This book (the title is a variation on the title of Simon's autobiography, Models of My Life) is a collection of short essays, all original, by colleagues from many fields who felt Simon's influence and mourn his loss. Mixing reminiscence and analysis, the book represents "a small acknowledgment of a large debt." Each of the more than forty contributors was asked to write about the one work by Simon that he or she had found most influential. The editors then grouped the essays into four sections: "Modeling Man," "Organizations and Administration," "Modeling Systems," and "Minds and Machines." The contributors include such prominent figures as Kenneth Arrow, William Baumol, William Cooper, Gerd Gigerenzer, Daniel Kahneman, David Klahr, Franco Modigliani, Paul Samuelson, and Vernon Smith. Although they consider topics as disparate as "Is Bounded Rationality Unboundedly Rational?" and "Personal Recollections from 15 Years of Monthly Meetings," each essay is a testament to the legacy of Herbert Simon—to see the unity rather than the divergences among disciplines.

An interactive journal that serves as a joyful, inspirational guide to building the life you've always dreamed of, using the principles and creative process of an award-winning product designer. Life, just like a design problem, is full of constraints -- time, money, age, location, and circumstances. You can’t have everything, so you have to be creative to make what you want and what you need co-exist. Design the Life You Love is a joyful, inspirational guide to building the life you’ve always wanted, using the principles and creative process of an award-winning product designer. Through four steps that reveal hidden skills and wisdom, anyone can design a life they love!