Develops different mathematical methods and tools to model living systems. This book presents material that can be used in such real-world applications as immunology, transportation engineering, and economics. It is of interest to those involved in modeling complex social systems and living matter in general.

This book illustrates how models of complex systems are built up and provides indispensable mathematical tools for studying their dynamics. This second edition includes more recent research results and many new and improved worked out examples and exercises.

This work aims to foster the interdisciplinary dialogue between mathematicians and socio-economic scientists. Interaction among scholars and practitioners traditionally coming from different research areas is necessary more than ever in order to better understand many real-world problems we face today. On the one hand, mathematicians need economists and social scientists to better address the methodologies they design in a more realistic way; on the other hand, economists and social scientists need to be aware of sound mathematical modelling tools in order to understand and, ultimately, solve the complex problems they encounter in their research. With this goal in mind, this work is designed to take into account a multidisciplinary approach that will encourage the transfer of knowledge, ideas, and methodology from one discipline to the other. In particular, the work has three main themes: Demystifying and unravelling complex systems; Introducing models of individual behaviours in the social and economic sciences; Modelling socio-economic sciences as complex living systems. Specific tools examined in the work include a recently developed modelling approach using stochastic game theory within the framework of statistical mechanics and progressing up to modeling Darwinian evolution. Special attention is also devoted to social network theory as a fundamental instrument for the understanding of socio-economic systems.​

Modeling of Complex Systems: An Introduction describes the framework of complex systems. This book discusses the language of system theory, taxonomy of system concepts, steps in model building, and establishing relations using physical laws. The statistical attributes of data, generation of random numbers fundamental problems of recognition, and input-output type models are also elaborated. This text likewise covers the optimization with equality constraints, transfer function models, and competition among species. This publication is written primarily for senior undergraduate students and beginning graduate students who are interested in an interdisciplinary or multidisciplinary approach to large-scale or complex problems of contemporary societal interest.

This book develops the mathematical tools essential for students in the life sciences to describe interacting systems and predict their behavior. From predator-prey populations in an ecosystem, to hormone regulation within the body, the natural world abounds in dynamical systems that affect us profoundly. Complex feedback relations and counter-intuitive responses are common in nature; this book develops the quantitative skills needed to explore these interactions. Differential equations are the natural mathematical tool for quantifying change, and are the driving force throughout this book. The use of Euler’s method makes nonlinear examples tractable and accessible to a broad spectrum of early-stage undergraduates, thus providing a practical alternative to the procedural approach of a traditional Calculus curriculum. Tools are developed within numerous, relevant examples, with an emphasis on the construction, evaluation, and interpretation of mathematical models throughout. Encountering these concepts in context, students learn not only quantitative techniques, but how to bridge between biological and mathematical ways of thinking. Examples range broadly, exploring the dynamics of neurons and the immune system, through to population dynamics and the Google PageRank algorithm. Each scenario relies only on an interest in the natural world; no biological expertise is assumed of student or instructor. Building on a single prerequisite of Precalculus, the book suits a two-quarter sequence for first or second year undergraduates, and meets the mathematical requirements of medical school entry. The later material provides opportunities for more advanced students in both mathematics and life sciences to revisit theoretical knowledge in a rich, real-world framework. In all cases, the focus is clear: how does the math help us understand the science?

Award-winning prof brings you from first-year classes to the frontiers of systems and synthetic biology, epidemic modeling, and imaging. Physical Models of Living Systems first develops the frameworks needed to understand modern ideas about inference from data, as they relate to biological physics research. Later chapters develop stochastic simulation as a tool to handle more complex systems, and then dynamical systems theory applied to cellular control networks, both natural and synthetic. Along the way, you'll also see the foundations of revolutionary advances in imaging (superresolution and cryo-electron microscopy), along with epidemic modeling, mechanobiology, excitable media, and more. The text also has significant overlap with competencies covered in the MCAT exam. Dozens of problems at all levels, many of them new in this edition, will help you to gain simulation and data visualization skills useful in any branch of quantitative science research.

The theory and practice of modeling cities and regions as complex, self-organizing systems, presenting widely used cellular automata-based models, theoretical discussions, and applications. Cities and regions grow (or occasionally decline), and continuously transform themselves as they do so. This book describes the theory and practice of modeling the spatial dynamics of urban growth and transformation. As cities are complex, adaptive, self-organizing systems, the most appropriate modeling framework is one based on the theory of self-organizing systems—an approach already used in such fields as physics and ecology. The book presents a series of models, most of them developed using cellular automata (CA), which are inherently spatial and computationally efficient. It also provides discussions of the theoretical, methodological, and philosophical issues that arise from the models. A case study illustrates the use of these models in urban and regional planning. Finally, the book presents a new, dynamic theory of urban spatial structure that emerges from the models and their applications. The models are primarily land use models, but the more advanced ones also show the dynamics of population and economic activities, and are integrated with models in other domains such as economics, demography, and transportation. The result is a rich and realistic representation of the spatial dynamics of a variety of urban phenomena. The book is unique in its coverage of both the general issues associated with complex self-organizing systems and the specifics of designing and implementing models of such systems.

This book deals with the most fundamental and essential techniques to simulate complex systems, from the dynamics of molecules to the spreading of diseases, from optimization using ant colonies to the simulation of the Game of Life.

An introduction to the mathematical concepts and techniques needed for the construction and analysis of models in molecular systems biology. Systems techniques are integral to current research in molecular cell biology, and system-level investigations are often accompanied by mathematical models. These models serve as working hypotheses: they help us to understand and predict the behavior of complex systems. This book offers an introduction to mathematical concepts and techniques needed for the construction and interpretation of models in molecular systems biology. It is accessible to upper-level undergraduate or graduate students in life science or engineering who have some familiarity with calculus, and will be a useful reference for researchers at all levels. The first four chapters cover the basics of mathematical modeling in molecular systems biology. The last four chapters address specific biological domains, treating modeling of metabolic networks, of signal transduction pathways, of gene regulatory networks, and of electrophysiology and neuronal action potentials. Chapters 3–8 end with optional sections that address more specialized modeling topics. Exercises, solvable with pen-and-paper calculations, appear throughout the text to encourage interaction with the mathematical techniques. More involved end-of-chapter problem sets require computational software. Appendixes provide a review of basic concepts of molecular biology, additional mathematical background material, and tutorials for two computational software packages (XPPAUT and MATLAB) that can be used for model simulation and analysis.

This MPDI book comprises a number of selected contributions to a Special Issue devoted to the modeling and simulation of living systems based on developments in kinetic mathematical tools. The focus is on a fascinating research field which cannot be tackled by the approach of the so-called hard sciences—specifically mathematics—without the invention of new methods in view of a new mathematical theory. The contents proposed by eight contributions witness the growing interest of scientists this field. The first contribution is an editorial paper which presents the motivations for studying the mathematics and physics of living systems within the framework an interdisciplinary approach, where mathematics and physics interact with specific fields of the class of systems object of modeling and simulations. The different contributions refer to economy, collective learning, cell motion, vehicular traffic, crowd dynamics, and social swarms. The key problem towards modeling consists in capturing the complexity features of living systems. All articles refer to large systems of interaction living entities and follow, towards modeling, a common rationale which consists firstly in representing the system by a probability distribution over the microscopic state of the said entities, secondly, in deriving a general mathematical structure deemed to provide the conceptual basis for the derivation of models and, finally, in implementing the said structure by models of interactions at the microscopic scale. Therefore, the modeling approach transfers the dynamics at the low scale to collective behaviors. Interactions are modeled by theoretical tools of stochastic game theory. Overall, the interested reader will find, in the contents, a forward look comprising various research perspectives and issues, followed by hints on to tackle these.