This book focuses on recent advances, approaches, theories and applications related to mixture models. In particular, it presents recent unsupervised and semi-supervised frameworks that consider mixture models as their main tool. The chapters considers mixture models involving several interesting and challenging problems such as parameters estimation, model selection, feature selection, etc. The goal of this book is to summarize the recent advances and modern approaches related to these problems. Each contributor presents novel research, a practical study, or novel applications based on mixture models, or a survey of the literature. Reports advances on classic problems in mixture modeling such as parameter estimation, model selection, and feature selection; Present theoretical and practical developments in mixture-based modeling and their importance in different applications; Discusses perspectives and challenging future works related to mixture modeling.

Patients are not alike! This simple truth is often ignored in the analysis of me- cal data, since most of the time results are presented for the “average” patient. As a result, potential variability between patients is ignored when presenting, e.g., the results of a multiple linear regression model. In medicine there are more and more attempts to individualize therapy; thus, from the author’s point of view biostatis- cians should support these efforts. Therefore, one of the tasks of the statistician is to identify heterogeneity of patients and, if possible, to explain part of it with known explanatory covariates. Finite mixture models may be used to aid this purpose. This book tries to show that there are a large range of applications. They include the analysis of gene - pression data, pharmacokinetics, toxicology, and the determinants of beta-carotene plasma levels. Other examples include disease clustering, data from psychophysi- ogy, and meta-analysis of published studies. The book is intended as a resource for those interested in applying these methods.

An up-to-date, comprehensive account of major issues in finitemixture modeling This volume provides an up-to-date account of the theory andapplications of modeling via finite mixture distributions. With anemphasis on the applications of mixture models in both mainstreamanalysis and other areas such as unsupervised pattern recognition,speech recognition, and medical imaging, the book describes theformulations of the finite mixture approach, details itsmethodology, discusses aspects of its implementation, andillustrates its application in many common statisticalcontexts. Major issues discussed in this book include identifiabilityproblems, actual fitting of finite mixtures through use of the EMalgorithm, properties of the maximum likelihood estimators soobtained, assessment of the number of components to be used in themixture, and the applicability of asymptotic theory in providing abasis for the solutions to some of these problems. The author alsoconsiders how the EM algorithm can be scaled to handle the fittingof mixture models to very large databases, as in data miningapplications. This comprehensive, practical guide: * Provides more than 800 references-40% published since 1995 * Includes an appendix listing available mixture software * Links statistical literature with machine learning and patternrecognition literature * Contains more than 100 helpful graphs, charts, and tables Finite Mixture Models is an important resource for both applied andtheoretical statisticians as well as for researchers in the manyareas in which finite mixture models can be used to analyze data.

Cluster analysis finds groups in data automatically. Most methods have been heuristic and leave open such central questions as: how many clusters are there? Which method should I use? How should I handle outliers? Classification assigns new observations to groups given previously classified observations, and also has open questions about parameter tuning, robustness and uncertainty assessment. This book frames cluster analysis and classification in terms of statistical models, thus yielding principled estimation, testing and prediction methods, and sound answers to the central questions. It builds the basic ideas in an accessible but rigorous way, with extensive data examples and R code; describes modern approaches to high-dimensional data and networks; and explains such recent advances as Bayesian regularization, non-Gaussian model-based clustering, cluster merging, variable selection, semi-supervised and robust classification, clustering of functional data, text and images, and co-clustering. Written for advanced undergraduates in data science, as well as researchers and practitioners, it assumes basic knowledge of multivariate calculus, linear algebra, probability and statistics.

Mixture Modelling for Medical and Health Sciences provides a direct connection between theoretical developments in mixture modelling and their applications in real world problems. The book describes the development of the most important concepts through comprehensive analyses of real and practical examples taken from real-life research problems in

With an A–Z format, this encyclopedia provides easy access to relevant information on all aspects of biometrics. It features approximately 250 overview entries and 800 definitional entries. Each entry includes a definition, key words, list of synonyms, list of related entries, illustration(s), applications, and a bibliography. Most entries include useful literature references providing the reader with a portal to more detailed information.

Mixture models have been around for over 150 years, and they are found in many branches of statistical modelling, as a versatile and multifaceted tool. They can be applied to a wide range of data: univariate or multivariate, continuous or categorical, cross-sectional, time series, networks, and much more. Mixture analysis is a very active research topic in statistics and machine learning, with new developments in methodology and applications taking place all the time. The Handbook of Mixture Analysis is a very timely publication, presenting a broad overview of the methods and applications of this important field of research. It covers a wide array of topics, including the EM algorithm, Bayesian mixture models, model-based clustering, high-dimensional data, hidden Markov models, and applications in finance, genomics, and astronomy. Features: Provides a comprehensive overview of the methods and applications of mixture modelling and analysis Divided into three parts: Foundations and Methods; Mixture Modelling and Extensions; and Selected Applications Contains many worked examples using real data, together with computational implementation, to illustrate the methods described Includes contributions from the leading researchers in the field The Handbook of Mixture Analysis is targeted at graduate students and young researchers new to the field. It will also be an important reference for anyone working in this field, whether they are developing new methodology, or applying the models to real scientific problems.

This practical introduction to second-order and growth mixture models using Mplus introduces simple and complex techniques through incremental steps. The authors extend latent growth curves to second-order growth curve and mixture models and then combine the two. To maximize understanding, each model is presented with basic structural equations, figures with associated syntax that highlight what the statistics mean, Mplus applications, and an interpretation of results. Examples from a variety of disciplines demonstrate the use of the models and exercises allow readers to test their understanding of the techniques. A comprehensive introduction to confirmatory factor analysis, latent growth curve modeling, and growth mixture modeling is provided so the book can be used by readers of various skill levels. The book’s datasets are available on the web. Highlights include: -Illustrative examples using Mplus 7.4 include conceptual figures, Mplus program syntax, and an interpretation of results to show readers how to carry out the analyses with actual data. -Exercises with an answer key allow readers to practice the skills they learn. -Applications to a variety of disciplines appeal to those in the behavioral, social, political, educational, occupational, business, and health sciences. -Data files for all the illustrative examples and exercises at www.routledge.com/9781138925151 allow readers to test their understanding of the concepts. -Point to Remember boxes aid in reader comprehension or provide in-depth discussions of key statistical or theoretical concepts. Part 1 introduces basic structural equation modeling (SEM) as well as first- and second-order growth curve modeling. The book opens with the basic concepts from SEM, possible extensions of conventional growth curve models, and the data and measures used throughout the book. The subsequent chapters in part 1 explain the extensions. Chapter 2 introduces conventional modeling of multidimensional panel data, including confirmatory factor analysis (CFA) and growth curve modeling, and its limitations. The logical and theoretical extension of a CFA to a second-order growth curve, known as curve-of-factors model (CFM), are explained in Chapter 3. Chapter 4 illustrates the estimation and interpretation of unconditional and conditional CFMs. Chapter 5 presents the logical and theoretical extension of a parallel process model to a second-order growth curve, known as factor-of-curves model (FCM). Chapter 6 illustrates the estimation and interpretation of unconditional and conditional FCMs. Part 2 reviews growth mixture modeling including unconditional growth mixture modeling (Ch. 7) and conditional growth mixture models (Ch. 8). How to extend second-order growth curves (curve-of-factors and factor-of-curves models) to growth mixture models is highlighted in Chapter 9. Ideal as a supplement for use in graduate courses on (advanced) structural equation, multilevel, longitudinal, or latent variable modeling, latent growth curve and mixture modeling, factor analysis, multivariate statistics, or advanced quantitative techniques (methods) taught in psychology, human development and family studies, business, education, health, and social sciences, this book’s practical approach also appeals to researchers. Prerequisites include a basic knowledge of intermediate statistics and structural equation modeling.

This book uses the EM (expectation maximization) algorithm to simultaneously estimate the missing data and unknown parameter(s) associated with a data set. The parameters describe the component distributions of the mixture; the distributions may be continuous or discrete. The editors provide a complete account of the applications, mathematical structure and statistical analysis of finite mixture distributions along with MCMC computational methods, together with a range of detailed discussions covering the applications of the methods and features chapters from the leading experts on the subject. The applications are drawn from scientific discipline, including biostatistics, computer science, ecology and finance. This area of statistics is important to a range of disciplines, and its methodology attracts interest from researchers in the fields in which it can be applied.