The Eighth International Conference on Miniaturized Systems in Chemistry and Life Science - B5Tas 2004 - is an annual meeting focusing on the research, development and application of miniaturized technologies and methodologies in chemistry and life science. The conference is celebrating its tenth anniversary after the first workshop at the University of Twente, The Netherlands in 1994. This research field is rapidly developing and changing towards a domain where core competence areas such as microfluidics, micro- and nanotechnology, materials science, chemistry, biology, and medicine are melting together to a truly interdisciplinary meeting place. This volume is the first in a two volume set, a valuable reference collection to all working in this field.

4M 2005 - First International Conference on Multi-Material Micro Manufacture

Part I The Nano-Scale Biological Systems in Nature; Molecular bio-motors in living cells – by T. Nishizaka; The form designed by viral genome – by K. Onodera; Part II Detection and Characterization Technology; Atomic force microscopy applied to nano-mechanics of the cell – by A. Ikai; Design, synthesis and biological application of fluorescent sensor molecules for cellular imaging – by K. Kikuchi; Dynamic visualization of cellular signaling – by Q. Ni and J. Zhang; Part III Fabrication Technology; Surface acoustic wave atomizer and electrostatic deposition – by Y. Yamagata; Electrospray deposition of biomolecules by V.N. Morozov; Part IV Processing Technology; Droplet handling – by T.Torii; Integrated microfluidic systems – by S. Kaneda and T. Fujii; Part V Applications; A novel non-viral gene delivery system: Multifunctional envelope-type nano device - by H. Hatakeyama, H. Akita, K. Kogure, and H. Harashima; Biosensors - by M. Saito, H.M. Hiep, N. Nagatani, and E.Tamiya; Micro bioreactors – by Sato and T. Kitamori

In this 2nd edition of Micro-Drops and Digital Microfluidics, Jean Berthier explores the fundamentals and applications of digital microfluidics, enabling engineers and scientists to design this important enabling technology into devices and harness the considerable potential of digital microfluidics in testing and data collection. This book describes the most recent developments in digital microfluidics, with a specific focus on the computational, theoretical and experimental study of microdrops. Unique in its emphasis on digital microfluidics and with diverse applications ranging from drug delivery to point-of-care diagnostic chips, organic synthesis to microreactors, Micro-Drops and Digital Microfluidics meets the needs of audiences across the fields of bioengineering and biotechnology, and electrical and chemical engineering. - Authoritative reporting on the latest changes in microfluidic science, where microscopic liquid volumes are handled as ""microdrops"" and separately from ""nanodrops." - A methodical examination of how liquid microdrops behave in the complex geometries of modern miniaturized systems and interact with different morphological (micro-fabricated, textured) solid substrates - A thorough explanation of how capillary forces act on liquid interfaces in contact with micro-fabricated surfaces - Analysis of how droplets can be manipulated, handled, or transported using electric fields (electrowetting), acoustic actuation (surface acoustic waves), or by a carrier liquid (microflow) - A fresh perspective on the future of microfluidics

Explosive growth in the field of microsystem technology (MST) has introduced a variety of promising products in major disciplines from microelectronics to life sciences. Especially the life sciences and health care business was, and is expected to be a major market for MST products. Undoubtedly the merging of biological sciences with micro- and nanoscience will create a scientific and technological revolution in future. Microminiaturization of devices, down to the nanoscale, approaching the size of biological structures, will be a prerequisite for the future success of life sciences. Bioanalytical and therapeutic micro- and nanosystems will be mandatory for system biologists in the long run, to obtain insight into morphology, the function and the interactive processes of the living system. With such a deeper understanding new and personalized drugs could be developed leading to a revolution in life sciences. Today, microanalytical devices are used in clinical analytics or molecular biology as gene chips. In parallel, standard microbiomedical products are employed in the intensive care and surgical theatre, mainly for monitoring and implantation purposes. The gap between these two different scientific fields will be closed, however, as soon as functional micro devices can be produced, allowing a deeper view into the function of cells and whole organisms. Here, a new discipline evolved which focuses on microsystems for living systems called "BIOMEMS". In this review at a glance the exciting field of bio-microsystems, from their beginnings to indicators of future successes are presented. It will also show that a broad penetration of micro and nano technologies into biology and medicine will be mandatory for future scientific and new product development progress in life science.

This book addresses Lab-on-a-Chip devices. It focuses on microfluidic technologies that have emerged in the past decade. Coverage presents a comprehensive listing of the most promising microfluidic technologies in the Lab-on-a-Chip field. It also details technologies that can be viewed as toolboxes needed to set up complex Lab-on-a-Chip systems.

With contributions from an internationally-renowned group of experts, this book uses a multidisciplinary approach to review recent developments in the field of smart sensor systems, providing complete coverage of all important system and design aspects, their building blocks and methods of signal processing. It examines topics over the whole range of sensor technology from the theory and constraints of basic elements, the applied techniques and electronic, up to the level of application-orientated issues. Developed as a complementary volume to ‘Smart Sensor Systems’ (Wiley 2008), which introduces the theoretical foundations, this volume focuses on practical applications, including: State-of-the-art techniques for designing smart sensors and smart sensor systems, with measurement techniques at system level, such as collaboration and trimming, and impedance-measurement techniques. Sensing elements and sensor systems for the measurement of mechanical quantities, and microarrays for DNA detection. Circuitdesign for sensor systems, such as the design of low-noise amplifiers, and measurement techniques at device level, such as dynamic offset cancellation and optical imagers. Implantable smart sensors for bio-medical applications and automotive sensors. A supplementary website hosts case studies and a solutions manual to the problems Smart Sensor Systems: Emerging Technologies and Applications will greatly benefit final year undergraduate and postgraduate students in the areas of electrical, mechanical and chemical engineering, and physics. Professional engineers and researchers in the microelectronics industry, including microsystem developers, will also find this a thorough and useful volume.

In modern drug discovery and development, chemical synthesis is one of the key technologies. For the rapid preparation of new test compounds and drug development candidates, several innovative technologies with great potential have emerged. This book offers a compact overview of the current status of these technologies and includes many real-life examples from industry and academic institutions.

For the past decade, new research fields utilizing microfluidics have been formed. General micro-integration methods were proposed, and the supporting fundamental technologies were widely developed. These methodologies have made various applications in the fields of analytical and chemical synthesis, and their superior performances such as rapid, simple, and high efficient processing have been proved. Recently, the space is further downscaling to 101 103nm scale (we call the space extended-nano space). The extended-nano space located between the conventional nanotechnology (100 101nm) and microtechnology (>1 m), and the research tools are not well established. In addition, the extended-nano space is a transient space from single molecules to bulk condensed phase, and fluidics and chemistry are not unknown. For these purposes, basic methodologies were developed, and new specific phenomena in fluidics and chemistry were found. These new phenomena were applied to unique chemical operations such as concentration and ion selection. The new research fields which are now being created are quite different from those in microspace. Unique devices are also increasingly being reported. In this book, we describe the fundamental technologies for extended-nano space and show the unique liquid properties found in this space and applications for single molecule or cell analysis. The research area is very new and hence, exciting. In contrast to other specialized areas, the research fields require wide knowledge (chemistry, fluidics, mechanics, photonics, biology etc.) and state-of-the-art technologies (bottom-up and top-down fabrication for various hard and soft materials, precise fluidic control, single molecule detection methods, and particle surface modification methods etc.), which have not been not covered by conventional review papers or books. Therefore, researchers or students new to the field need a new book covering these fields including recent research topics, applications and problems to be solved in the future. Our motivation is to summarize the state-of-the-art technologies for research and demonstrate new chemistry and fluidics in extended-nano space for students and researchers in academia or industry. We also emphasize the potential large impact microfluidic technologies have on chemistry and biochemistry.