Microrna Interference Technologies
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Author |
: Zhiguo Wang |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 198 |
Release |
: 2009-06-11 |
ISBN-10 |
: 9783642004896 |
ISBN-13 |
: 364200489X |
Rating |
: 4/5 (96 Downloads) |
Synopsis MicroRNA Interference Technologies by : Zhiguo Wang
MicroRNAs (miRNAs), endogenous noncoding regulatory mRNAs of around 22-nucleotides long, have rapidly emerged as one of the key governors of the gene expression regulatory program in cells of varying species, with ever-increasing implications in the control of the fundamental biological processes and in the pathogenesis of adult humans. The exciting findings in this field have inspired us with a premise and a promise that miRNAs will ultimately be taken to the heart for therapy of human disease. While miRNAs have been considered potential therapeutic targets for disease treatment, it remains obscured what strategies we can use to achieve the goal. In the past years, we have witnessed a rapid evolving of many creative, innovative, inventive strategies and methodologies pertinent to miRNA research and applications. These technologies have convincingly demonstrated their efficacy and reliability in producing gain-of-function or loss-of-function of miRNAs through targeting miRNA expression/biogenesis/function, providing new tools for elucidating miRNA functions and opening up a new avenue for the development of new agents targeting miRNAs for therapeutic aims. The present book provides comprehensive descriptions of these technologies and their applications to miRNA research and to new drug design for miRNA-related diseases. It starts with an overview of up-to-date knowledge of miRNA biology and the potential of miRNAs as therapeutic targets for human disease, followed by an introduction of the new concept of miRNA interference (miRNAi) and the perspectives of miRNAi technologies in general terms. In the following, each chapter introduces one of the miRNAi technologies with detailed descriptions of state-of-the-art design, procedures, principles and applications to basic research, R and D and clinical therapy.
Author |
: Volker A. Erdmann |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 460 |
Release |
: 2010-09-02 |
ISBN-10 |
: 9783642121685 |
ISBN-13 |
: 3642121683 |
Rating |
: 4/5 (85 Downloads) |
Synopsis RNA Technologies and Their Applications by : Volker A. Erdmann
RNA technologies are the driving forces of modern medicine and biotechnology. They combine the fields of biochemistry, chemistry, molecular biology, cell biology, physics, nanotechnology and bioinformatics. The combination of these topics is set to revolutionize the medicine of tomorrow. After more than 15 years of extensive research in the field of RNA technologies, the first therapeutics are ready to reach the first patients. Thus we are witnessing the birth of a very exciting time in the development of molecular medicine, which will be based on the methods of RNA technologies. This volume is the first of a series. It covers various aspects of RNA interference and microRNAs, although antisense RNA applications, hammerhead ribozyme structure and function as well as non-coding RNAs are also discussed. The authors are internationally highly respected experts in the field of RNA technologies.
Author |
: Kenneth A. Howard |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 348 |
Release |
: 2012-10-19 |
ISBN-10 |
: 9781461447436 |
ISBN-13 |
: 1461447437 |
Rating |
: 4/5 (36 Downloads) |
Synopsis RNA Interference from Biology to Therapeutics by : Kenneth A. Howard
The enormous potential of siRNA as a therapeutic has led to an explosion of interest from the scientific community. There has been intense interest from Big Pharma to capitalise on this new technology but the fact remains that delivery is a key determinant in realizing the full clinical potential of RNA interference. There is an urgent need for better delivery methods to take this technology forward. This book addresses the role of different RNAi molecules in cellular processes as rational for diagnostic and therapeutic approaches. This book will cover RNAi therapeutic design to optimize siRNA potency and reduce off-target effects and current delivery technologies to overcome both intracellular and extracellular barriers. The reader will gain an insight into RNA interference from the cellular mechanisms to screening to siRNA design right through to diagnostic and therapeutic applications.
Author |
: R. K. Gaur |
Publisher |
: CRC Press |
Total Pages |
: 380 |
Release |
: 2016-04-19 |
ISBN-10 |
: 9781439873250 |
ISBN-13 |
: 1439873259 |
Rating |
: 4/5 (50 Downloads) |
Synopsis RNAi Technology by : R. K. Gaur
RNAi technology is used for large-scale screens that systematically shut down each gene in the cell, which can help identify the components necessary for a particular cellular process or an event such as cell division. Exploitation of the pathway is also a promising tool in biotechnology and medicine. Introducing new technology in the study of RNA
Author |
: Shao-Yao Ying |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 365 |
Release |
: 2008-02-04 |
ISBN-10 |
: 9781597451239 |
ISBN-13 |
: 1597451231 |
Rating |
: 4/5 (39 Downloads) |
Synopsis MicroRNA Protocols by : Shao-Yao Ying
MicroRNA Protocols provides diverse, novel, and useful descriptions of miRNAs in several species, including plants, worms, flies, fish, chicks, mice, and humans. These include some useful adaptations and applications that could be relevant to the wider research community who are already familiar with the identification of miRNAs. This volume will stimulate the reader to explore diverse ways to understanding the mechanism in which miRNAs facilitate the molecular aspects of the biomedical research.
Author |
: Krishnarao Appasani |
Publisher |
: Cambridge University Press |
Total Pages |
: 564 |
Release |
: 2005-01-17 |
ISBN-10 |
: 1139442651 |
ISBN-13 |
: 9781139442657 |
Rating |
: 4/5 (51 Downloads) |
Synopsis RNA Interference Technology by : Krishnarao Appasani
RNA Interference (RNAi) technology has rapidly become one of the key methods used in functional genomics. RNAi is used to block the expression of genes and create phenotypes that can potentially yield clues about the function of these genes. In the postgenomic era, the elucidation of the physiological function of genes has become the rate-limiting step in the quest to develop 'gene-based drugs' and RNAi could potentially play a pivotal role in the validation of such novel drugs. In this overview, the basic concepts and applications of RNAi biology are discussed. Leading experts from both academia and industry have contributed to this invaluable reference. The volume is forwarded by Andrew Fire, one of the winners of the 2006 Nobel Prize for the discovery of RNA Interference.
Author |
: Dirk Grimm |
Publisher |
: Academic Press |
Total Pages |
: 264 |
Release |
: 2011-08-26 |
ISBN-10 |
: 9780124157958 |
ISBN-13 |
: 0124157955 |
Rating |
: 4/5 (58 Downloads) |
Synopsis Cellular RNA Interference Mechanisms by : Dirk Grimm
This volume explores some of the most exciting recent advances in basic research on cellular RNA interference mechanisms and how this knowledge is leading to advances in the various fields. This series provides a forum for discussion of new discoveries, approaches, and ideas Contributions from leading scholars and industry experts Reference guide for researchers involved in molecular biology and related fields
Author |
: Muhammad Sohail |
Publisher |
: CRC Press |
Total Pages |
: 398 |
Release |
: 2004-08-27 |
ISBN-10 |
: 9780203489253 |
ISBN-13 |
: 020348925X |
Rating |
: 4/5 (53 Downloads) |
Synopsis Gene Silencing by RNA Interference by : Muhammad Sohail
Maximizing the potential of RNA interference in functional genomics - as well as in the development of therapeutics - continues to be at the forefront of biomedical research. Unlike journal articles, Gene Silencing by RNA Interference: Technology and Application combines essential background to the RNAi field with practical techniques designed by r
Author |
: Dr. Tim Doran |
Publisher |
: CABI |
Total Pages |
: 269 |
Release |
: 2009 |
ISBN-10 |
: 9781845934101 |
ISBN-13 |
: 1845934105 |
Rating |
: 4/5 (01 Downloads) |
Synopsis RNA Interference by : Dr. Tim Doran
This methods manual provides an introduction to RNA interference, the theory behind its many applications, and specific protocols for RNAi, in organisms from plants and C.elegans to Drosophila and mammals. There are also chapters covering small hairpin RNAs and viral-induced gene silencing.
Author |
: Scott Q. Harper |
Publisher |
: Humana Press |
Total Pages |
: 0 |
Release |
: 2011-05-16 |
ISBN-10 |
: 161779113X |
ISBN-13 |
: 9781617791130 |
Rating |
: 4/5 (3X Downloads) |
Synopsis RNA Interference Techniques by : Scott Q. Harper
Non-coding, inhibitory microRNAs have emerged as important modulators of cellular gene expression, through a process called RNA interference (RNAi). To date, hundreds of conserved and species-specific microRNAs have been identified in organisms ranging from single-celled algae to humans. Many of these tiny RNAs are now known to play fundamental roles in developmental biology and disease pathogenesis. In addition, RNAi has emerged as a technology useful for manipulating gene expression. In RNA Interference Techniques, expert researchers present detailed methods for designing and delivering artificial inhibitory RNAs to neural tissue and for detecting or cloning endogenous microRNAs, all in order to aid investigators’ attempts to ask basic biological questions or develop therapeutics for dominant neurogenetic disorders, cancer, or viral infection. As a volume in the successful Neuromethods series, the chapters provide authoritative accounts of the most commonly used approaches in the field today. Cutting-edge and concise, RNA Interference Techniques promises to support the vital research in the field of RNAi and miRNAs, ever-continuing to grow rapidly and gain increasing importance in basic and translational biology.