The major histocompatibility complex is the subject of much research in the immunology area. There is great interest in the structure of MHC proteins and in their function as antigen presenting molecules. Many immunology labs are now faced with the prospect of tackling biochemical and genetic techniques in order to study these molecules, and these two Practical Approach volumes provide the ideal introduction. MHC 1, Antigen Processing and Presentation, is complemented by MHC 2, Genes, Cells, and Molecules.

Volume 1 of a series of books intended to help students of medicine, veterinary science, dentistry and biomedical science interpret the latest findings in haematology, provide a backdrop for future advances and provide more focused and in-depth reading for those wishing to follow a laboratory or clinically-based career. Each of the contributions is written by an authority in the field and is information rather than reference rich, providing an up-to-date resume of the latest advances in the subject and a focus for further reading.

The Handbook of Cell Signaling is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The subject matter has been divided into five main parts (each of which is headed by a recognized expert in the field):* Initiation: Extracellular and Membrane Events* Transmission: Effectors and Cytosolic Events * Nuclear Responses: Gene Expression and Translation* Events in Intracellular Compartments* Cell-Cell and Cell-Matrix Interactions Covered in extensive detail, these areas will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. Tabular and well-illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field.Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field!* Contains approximately 470 articles* Provides well-organized sections on each essential area in signaling* Includes discussion on everything from ligand/receptor interactions to organ/organism responses* Extremely user-friendly

Dependable, current, and complete, Robbins and Cotran Pathologic Basis of Disease, Volume 1 - General Pathology is the perennially best-selling text that you'll use long after your medical student days are behind you. A world-class author team headed by Drs. Vinay Kumar, Abul Abbas, and Jon Aster, delivers the latest, most essential pathology knowledge in a readable, interesting manner, ensuring optimal understanding of the latest basic science and clinical content. High-quality photographs and full-color illustrations highlight new information in molecular biology, disease classifications, new drugs and drug therapies, and much more. Volume 1 - Chapter 1 to 10 features on: - Rely on uniquely authoritative and readable coverage, ideal for USMLE or specialty board preparation, as well as for course work. - Simplify your study with an outstanding full-color, highly user-friendly design. - Short Answer Questions (SAQs) available online on MedEnact.

Key Features: What is PRIMES? An ALL IN ONE book for quick revision before a PGME examsCompletely Different approach for PGMEE preparation8000 Qs covered of all Exams 2007 to 2017 in this volumeQuestions organized according to Chapters, Topics and then Subtopics into each subjectsFocus on Most Recent High yielding questions 2016–17Specialized subjects are preferably arranged into Cranio-Caudal FashionAuthentic References from Standard TextbooksAll Subjects' Questions Reviewed by Subject ExpertsComprehensive question oriented High-yield Points and High Scoring One Liners given in each subject200 Tables & 150 Colored Illustrations & Photographs High Yield Topics are covered in tabulated formQuestions & High–yield Points are compatible with latest Examination trends conducted by NBE

The metabolism and functions of inositol phosphates impinge on various branches of biochemistry, physiology, and molecular biology, and methodological information is in consequence scattered far and wide. This book unites a selection of the most fundamental and commonly used techniques from leading international signal transduction laboratories, and brings together many valuable protocols for purifying and assaying inositides and related compounds. A novel feature is a catalogue of non-commercial sources of synthetic inositide analogues.

The first-ever comprehensive book written on early English immigration to Canada, Planters, Paupers, and Pioneers introduces a series of three titles on The English in Canada. Focusing on factors that brought the English to Atlantic Canada, it traces the English arrivals to their various settlements in Nova Scotia, New Brunswick, Prince Edward Island, and Newfoundland, and considers their reasons for leaving their homeland. Who were they? When did they arrive? Were they successful? What was their lasting impact? Drawing on wide-ranging documentary sources, including passenger lists, newspaper shipping reports, and the wealth of material to be found in English county record offices and in Canadian national and provincial archives, the book provides extensive details of the immigrants and their settlements and gives details of more than 700 Atlantic crossings — essential reading for individuals wishing to trace English and Canadian family links or to deepen understanding of the emigration process.

Located at the interface between blood and the brain, the blood-brain barrier is a dynamic permeability barrier formed by a continuous layer of specialized endothelial cells endowed with important permeability, transport, and regulatory functions that both protect the internal milieu of the brain and allow essential nutrients to be transported into

These volumes, Cytolytic Lymphocytes and Complement: Effectors of the Immune System, originate from the realization that pathways of recognition and killings of foreign targets follow similar routes in the humoral and cellular part of the immune system. In particular, the homology of immunoglobins with the T-cell-MHC-antigen receptor at the beginning of the recognition sequence and the homology of complement component C9 with lymphocyte perforin 1 (P1) as pore formers at the end of the effector sequence are striking examples.