The goal of the second edition is to introduce the advance undergraduate or graduate student and more seasoned research scientists in any of the allied health sciences to a wide array of methodological and biostatistical issues, as they occur in the context of both published and ongoing research. Some sixty-four articles published between 1992 and 2002 have been selected from the Journal of Clinical and Experimental Neuropsychology, The Clinical Neuropsychologist, and Child Neuropsychology and reproduced in this volume. While building upon a working knowledge and understanding of the basic univariate data analytic techniques and the research designs to which they apply, the approach to the more complex multivariate techniques is presented primarily at a conceptual and essentially non-mathematical level. While the issue of the complexity of some of the more recent and standard approaches to data analytic strategies, and their important role to specific research designs is important to convey, there remains an even more fundamental issue of whether the results of correctly applied data analytic strategies make any practical or clinical sense, above and beyond their having reached levels of "statistical significance". These critical issues are addressed throughout various commentaries that the editors make at appropriate points in the text. The volume will appeal to advanced undergraduate and graduate students as well as clinical neuropsychologists and research scientists in any of the allied health disciplines.

Containing 50 chapters by some of the most prominent clinical neuropsychologists, the Textbook of Clinical Neuropsychology sets a new standard in the field in its scope, breadth, and scholarship. Unlike most other books in neuropsychology, the Textbook is organized primarily around syndromes, disorders, and related clinical phenomena. Written for the clinician at all levels of training, from the beginner to the journeyman, the Textbook presents contemporary clinical neuropsychology in a comprehensive volume. Chapters are rich with reviews of the literature and clinical case material spanning a range from pediatric to adult and geriatric disorders. Chapter authors are among the most respected in their field, leaders of American Neuropsychology, known for their scholarship and professional leadership. Rarely have so many distinguished members of one discipline been in one volume. This is essential reading for students of neuropsychology, and all others preparing for careers in the field.

This book, the first of three volumes, provides a thorough background to the emerging field of neurobehavioral toxicology by looking at current clinical approaches and tests, as well as assessing current clinical research. The analysis of the impact of toxins on the human nervous system is particularly pertinent given the ongoing expansion of pharmaceuticals, industrial hazards, biological warfare and global pollution. A comprehensive introduction to neurobehavioral toxicology, this work will be of interest to practicing neurologists and neuropsychologists, as well as to occupational medicine physicians and medical toxicologists.

Although investigated for over 100 years, it is only now that we are beginning to understand how speed of information processing is affected in various clinical populations. Processing speed has a major impact on higher level cognitive abilities and is extremely vulnerable to neurological insult and the aging process. The importance of processing speed with respect to brain function, cognition and overall quality of life is now the focus of a new and exciting body of research in clinical populations. This book provides a scholarly and clinically sensitive review of research on processing speed and its issues in clinical populations. Readers will come away with an in-depth understanding of human information processing speed including its historical development, its relationship to other cognitive functions, the developmental course of the ability across the lifespan, and its impact on everyday life in various clinical populations. Other highlights of the text are its discussion of the speed vs. accuracy trade-off, tools available for measuring processing speed, the unfolding research on genetic contributions to processing speed, and the latest ideas in rehabilitation. With contributing authors who are experts in their fields, Information Processing Speed in Clinical Populations represents a valuable resource for researchers, scholars, and clinicians by providing a concise summary of the existing research on processing speed across an array of disciplines and populations.

Substance use continues to be a major public health problem, and the ramifications of this are manifold. For instance, at present, on a yearly basis, the total economic cost of substance misuse is literally hundreds of billions of dollars. These costs are related to a number of factors, including, but not limited to, treatment and prevention, reduced job productivity and/or absenteeism, interdiction by the criminal justice, and incarceration. There are many more psychosocial consequences of substance misuse, and these have been well–documented over the past four to five decades; in contrast, with the exception of alcohol, the effects of substance misuse on the brain have received attention only in the past 10 to 15 years. An emerging body of literature has reported on the effects of various drugs on neuropsychological functioning, including benzodiazepines, cocaine, marijuana, MDMA, methamphetamine, nicotine, and opioids. Despite the fact that the neuropsychological consequences of many drugs of abuse are well–documented, to our knowledge, no one had previously published an edited volume that focused exclusively on this issue. Based on this fact, we decided to create a volume that would review the available literature regarding on this topic. Neuropsychology and Substance Misuse: State-of-the-Art and Future Directions explores cutting-edge issues, and will be of interest to clinical neuropsychologists who require the latest findings in this increasingly important area of neuropsychology.

The text provides a lifespan developmental approach to neuropsychology. It addresses the many issues in neuropsychological assessment that differ between younger and older adults. It describes the symptoms, neuropathology, diagnostic considerations, and treatment options of common neurological disorders associated with aging. It also addresses special considerations related to geriatric neuropsychology, such as ethical issues, family systems issues, decision-making capacity, cultural consideration, and medical/medication/substance use issues. Additionally, a list of resources for the elderly and their families is also provided.

Since the late 1800s psychologists have been interested in discerning the strategies subjects employ to solve psychological tests (Piaget, 1928, Werner, 1940, Gesell, 1941). Much of this work, however, has relied on qualitative observations. In the 1970s, Edith Kaplan adopted this approach to the analysis of standardized neuropsychological measures. Unlike her predecessors, Dr. Kaplan and her colleagues emphasized the application of modern behavioral neurology to the analysis of the test data. Her approach was later termed the Boston Process Approach to neuropsychological assessment. While Edith Kaplan's work generates a great deal of enthusiasm, the qualitative nature of her analyses did not allow for its adoption by mainstream neuropsychologists. However, in recent years this limitation has begun to be addressed. Clinicians and researchers have developed new methodologies for quantifying the Boston Process Approach, leading to the emergence of a new field, which is collectively termed the Quantified Process Approach. Quantified Process Approach to Neuropsychological Assessment outlines the rationale for the emergence of this new approach and reviews the state of the art research literature and up to date clinical applications as they pertain to the evaluation of neuropsychiatric, head injured, and learning disabled patients. When available, norms and scoring forms are included in the appendices.

This is the final volume in a three-volume work that has addressed the scientific methodologies relevant to clinical neurobehavioral toxicology. Volume III attends to what is known about industrial and environmental chemicals, medicines, and substances of abuse and how these agents affect the central nervous system. How to determine that a specified substance has caused harm is emphasized by way of case examples and discussion. Illnesses and behavioral variations that compete with toxicant-induced explanations for findings in a given case, as well as the various controversies that can arise around issues of diagnosis and causal determination, are treated comprehensively in this volume.

Cognitive reserve has emerged as a powerful concept for interpreting individual differences in susceptibility to, and recovery from, brain injury or pathology. Underlying cognitive reserve is the idea that individual differences in how cognitive tasks are mediated in the brain allow some people to cope with pathology to a greater degree than others. Cognitive Reserve: Theory and Applications describes in depth the source of these individual differences. This volume provides a comprehensive review of theory, research and clinical application of the cognitive reserve. Chapters explore the theoretical underpinnings of cognitive reserve, and evidence for its existence. Various approaches for studying this concept are addressed, including epidemiologic, cognitive experimental, and neuroimaging. Possible genetic and physiologic underpinnings of cognitive reserve are presented. Application of this concept to a wide range of situations, including child development, aging, Alzheimer’s disease, stroke, HIV, and head injury is discussed. The result is an up-to-date, global treatment of cognitive reserve that will be of interest to someone new to the concept or the experienced investigator.