Metformin may play in important role in the future in helping to prevent the development of diabetes: it is a strong candidate therapy for delaying the onset of the disease and potentially as part of a treatment programme to correct features of the metabolic syndrome. This book celebrates 50 years of research into metformin and its use in the treatment of diabetes. Metformin is still the drug of choice for managing patients with type 2 diabetes and all new drugs are tested in comparison with this, the gold standard. Comprising seven sections, addressing different aspects of research on metformin and its applications, this book is edited by a world class team of expert diabetologists and beautifully presented in two colour throughout. It also includes a bibliography of all papers published on metformin and a complete list of all authors on those papers.

Concise, easy to read, and designed for quick reference,Quick Guide to Kidney Transplantationis a compact resource for general nephrologists, residents, fellows, nurse practitioners, and others involved in the care of post-transplant patients. Focusing on must-know clinical information needed to provide optimal patient care, this expertly written guide helps you gain the knowledge and expertise you need in this complex area.

This book presents state of the art knowledge on diabetes in stroke, covering both basic and clinical aspects in detail. The focus is in particular on two major areas: general knowledge of diabetes and diabetes from a stroke neurologist’s perspective. Readers will find up-to-date information on glucose metabolism, the pathophysiology of diabetes, the clinical significance of diabetes in stroke, the differential influence of diabetes on stroke mechanisms, principles of diabetes care, advances in treatment options, and clinical practice in the real world. The individual components of pathophysiology, management, and key issues are fully addressed with the aid of complementary illustrations that facilitate understanding of practical aspects and enable the reader to retrieve fundamental information quickly. The book is timely in bringing together within one volume the most important current knowledge on diabetes in stroke. It will be invaluable for stroke physicians, epidemiologists, and students seeking to acquire up-to-date knowledge.

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.This volume focuses on insulin and IGFs. - Longest running series published by Academic Press - Contributions by leading international authorities

Diabetes has become a worldwide health problem, the global estimated prevalence approaches ten percent and the burden of this disease in terms of morbidity and mortality is unprecedented. The advances acquired through the knowledge of the mechanisms of the disease and the variety of therapeutic approaches contrast with the inability of private and public health systems in underdeveloped and even developed countries to achieve the goals of treatment. This paradox has been described in many sources: the surge of scientific advances contrast with an unprecedented amount of human suffering. Thus, a patient centered and an evidence based approach with the capacity to produce measurable clinical and economic outcomes is required. The purpose of this textbook is multiple: to offer a comprehensive resource covering all aspects of outpatient management; to address diabetes as a health problem from an epidemiological, economic and clinical perspective; to discuss the role of social determinants of health on the worldwide increase in diabetes; to highlight the challenges and obstacles in providing adequate care; and to outline a multidisciplinary approach to management in which medical visits retain their importance as part of a team comprising the patient, his or her family and a multidisciplinary group of health professionals who are able to move beyond the traditional approach of diabetes as a disease and greatly improve outcomes.

Over three editions the Textbook of Diabetes has built a reputation as a book that is extremely well-organized and easy to navigate, with exceptional illustrations and an excellent blend of clinical and scientific content. Previously edited by John Pickup and Gareth Williams this fourth edition has four brand new editors from across the globe. The editors have assembled an outstanding set of international contributors who provide insight on new developments in diabetes care and information on the latest treatment modalities used around the world. The new Textbook of Diabetes has been restructured into 12 parts in one accessible volume and is designed with the busy diabetes care team in mind. As well as retaining the elements that have made it such a popular brand, such as the outstanding full colour illustrations and text design, the new edition sees even greater emphasis on the clinical aspects of diabetes, with new chapters on managing patients with diabetes, the treatment of diabetes, and the delivery and organization of diabetes care, including: Non-insulin parenteral therapies New technologies for insulin administration and glucose monitoring The role of the multidisciplinary team There is also a companion website accompanying the book containing essential bonus material such as: Over 150 interactive MCQ's to help you improve and test your clinical knowledge All 500 figures from the book in a downloadable format to use in slides and presentations Chapter pdfs and chapter references with full links to PubMed If you want a modern, well-illustrated, international guide to diabetes this is the ideal reference book for you.

This volume includes the latest diagnostic criteria for PCOS and comprises the most up-to-date information about the genetic features and pathogenesis of PCOS. It critically reviews the methodological approaches and the evidence for various PCOS susceptibility genes. The book also discusses additional familial phenotypes of PCOS and their potential genetic basis. All four editors of this title are extremely prominent in the field of PCOS.

Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.