One of the few modern first-person accounts of Native American healers tells us about Indian life in this world and about life in the visionary medicine womans world. A compelling history.

Literally Italian for "bad air," malaria once plagued Rome, tropical trade routes and colonial ventures into India and South America and the disease has no known antidote aside from the therapeutic effects of the "miraculous" quinine. This first book from journalist Honigsbaum is a rousing history of the search for febrifuge or, more specifically, the rare red cinchona tree, the bark from which quinine is derived.

Dengue fever is the world’s most prevalent mosquito-borne illness, but Alex Nading argues that people in dengue-endemic communities do not always view humans and mosquitoes as mortal enemies. Drawing on two years of ethnographic research in urban Nicaragua and challenging current global health approaches to animal-borne illness, Mosquito Trails tells the story of a group of community health workers who struggle to come to terms with dengue epidemics amid poverty, political change, and economic upheaval. Blending theory from medical anthropology, political ecology, and science and technology studies, Nading develops the concept of “the politics of entanglement” to describe how Nicaraguans strive to remain alive to the world around them despite global health strategies that seek to insulate them from their environments. This innovative ethnography illustrates the continued significance of local environmental histories, politics, and household dynamics to the making and unmaking of a global pandemic.

This guide meticulously describes and rates 47 off the beaten path routes located near the towns of Sacramento, Redding (west), Red Bluff, Clear Lake, McCloud, Mount Shasta, Yreka, Crescent City, and Fort Bidwell. NEW, full COLOR additions to our Trails series! These handy 6x9? books include scenic drives plus a whole lot more! Including some of America's best mountain biking, hiking, camping and fishing areas! Ghost towns galore? Step back into the past while wandering through abandoned mining areas, old buildings, and even entire towns. INCLUDES GPS coordinates throughout each book.

Successful drug development relies on accurate and efficient clinical trials to deliver the best and most effective pharmaceuticals and clinical care to patients. However, the current model for clinical trials is outdated, inefficient and costly. Clinical trials are limited by small sample sizes that do not reflect variations among patients in the real world, financial burdens on participants, and slow processes, and these factors contribute to the disconnect between clinical research and clinical practice. On November 28-29, the National Academies of Sciences, Engineering, and Medicine convened a workshop to investigate the current clinical trials system and explore the potential benefits and challenges of implementing virtual clinical trials as an enhanced alternative for the future. This publication summarizes the presentations and discussions from the workshop.

Discover classic destinations and lesser-known jewels of Glacier National Park through 42 incomparable hikes. With its crystalline lakes, towering mountains, impressive waterfalls, diverse plant and animal life, and, of course, dynamic glaciers, Glacier National Park offers countless opportunities for outdoor adventure. To find the best of them, follow expert author Jean Arthur—who has spent decades hiking hundreds of miles of trails throughout the park! Leave the roads to explore the hearts of both Glacier and Waterton Lakes National Parks—whether you’re looking for an easy family stroll through a grove of majestic red cedars, a 6-mile trek with spectacular views of snowfields that melt into wildflower meadows, or a 20-mile overnighter through some of the finest mountain scenery in the country. You’ll experience the best of the treasured national park that lies in the wilderness area of Montana’s Rocky Mountains. Inside you’ll find: 42 favorite routes for hikers, backpackers, and cyclists Detailed maps and elevation profiles Trailhead directions and “don’t get lost” milestones Key at-a-glance information, including trail length, difficulty, features, and facilities Expert trail commentary If you want to take a scenic walk to stretch your legs, a full-day hike, or a rewarding backpacking trip, you’ll find it in Top Trails: Glacier National Park.

Clinical trials are used to elucidate the most appropriate preventive, diagnostic, or treatment options for individuals with a given medical condition. Perhaps the most essential feature of a clinical trial is that it aims to use results based on a limited sample of research participants to see if the intervention is safe and effective or if it is comparable to a comparison treatment. Sample size is a crucial component of any clinical trial. A trial with a small number of research participants is more prone to variability and carries a considerable risk of failing to demonstrate the effectiveness of a given intervention when one really is present. This may occur in phase I (safety and pharmacologic profiles), II (pilot efficacy evaluation), and III (extensive assessment of safety and efficacy) trials. Although phase I and II studies may have smaller sample sizes, they usually have adequate statistical power, which is the committee's definition of a "large" trial. Sometimes a trial with eight participants may have adequate statistical power, statistical power being the probability of rejecting the null hypothesis when the hypothesis is false. Small Clinical Trials assesses the current methodologies and the appropriate situations for the conduct of clinical trials with small sample sizes. This report assesses the published literature on various strategies such as (1) meta-analysis to combine disparate information from several studies including Bayesian techniques as in the confidence profile method and (2) other alternatives such as assessing therapeutic results in a single treated population (e.g., astronauts) by sequentially measuring whether the intervention is falling above or below a preestablished probability outcome range and meeting predesigned specifications as opposed to incremental improvement.