The second edition of Mathematics as a Laboratory Tool reflects the growing impact that computational science is having on the career choices made by undergraduate science and engineering students. The focus is on dynamics and the effects of time delays and stochastic perturbations (“noise”) on the regulation provided by feedback control systems. The concepts are illustrated with applications to gene regulatory networks, motor control, neuroscience and population biology. The presentation in the first edition has been extended to include discussions of neuronal excitability and bursting, multistability, microchaos, Bayesian inference, second-order delay differential equations, and the semi-discretization method for the numerical integration of delay differential equations. Every effort has been made to ensure that the material is accessible to those with a background in calculus. The text provides advanced mathematical concepts such as the Laplace and Fourier integral transforms in the form of Tools. Bayesian inference is introduced using a number of detective-type scenarios including the Monty Hall problem.

This hands-on manual, with pedagogical features that draw the learner into the content, offers clear and complete coverage of the mathematical topics most often used in today’s clinical and medical laboratories. Furthermore, it provides a solid foundation for subsequent courses in the laboratory sciences. The first two chapters present a review of basic mathematical concepts. The remainder of the book provides students with a realistic means to build on previously learned concepts— both mathematical and scientific—to refine their mathematical skills, and to gauge their mastery of those skills. Outstanding features . . . • Each chapter opens with an outline, objectives, and key terms. • Key terms, highlighted within the text, are listed and defined in the glossary. • “Margin problems” and practice problem sets provide the chance to gain immediate proficiency. • Laboratory exercises and review problems allow students to apply what they’ve learned and assess their understanding and progress. • A special calculator icon signals explanations of calculator use for a particular mathematical function. • Study hints—“Keys to Success”—offer practical suggestions and guidance for maximizing achievement. • The workbook design enables users to solve problems and take notes directly on the pages.

Calculations for Molecular Biology and Biotechnology: A Guide to Mathematics in the Laboratory, Second Edition, provides an introduction to the myriad of laboratory calculations used in molecular biology and biotechnology. The book begins by discussing the use of scientific notation and metric prefixes, which require the use of exponents and an understanding of significant digits. It explains the mathematics involved in making solutions; the characteristics of cell growth; the multiplicity of infection; and the quantification of nucleic acids. It includes chapters that deal with the mathematics involved in the use of radioisotopes in nucleic acid research; the synthesis of oligonucleotides; the polymerase chain reaction (PCR) method; and the development of recombinant DNA technology. Protein quantification and the assessment of protein activity are also discussed, along with the centrifugation method and applications of PCR in forensics and paternity testing. - Topics range from basic scientific notations to complex subjects like nucleic acid chemistry and recombinant DNA technology - Each chapter includes a brief explanation of the concept and covers necessary definitions, theory and rationale for each type of calculation - Recent applications of the procedures and computations in clinical, academic, industrial and basic research laboratories are cited throughout the text New to this Edition: - Updated and increased coverage of real time PCR and the mathematics used to measure gene expression - More sample problems in every chapter for readers to practice concepts

Work at the biology bench requires an ever-increasing knowledge of mathematical methods and formulae. This is a compilation of the most common mathematical concepts and methods in molecular biology, with clear, straightforward guidance on their application to research investigations.

This book is an exploration of tools and mathematics and issues in mathematics education related to tool use. The book has five parts. The first part reflects on doing a mathematical task with different tools, followed by a mathematician's account of tool use in his work. The second considers prehistory and history: tools in the development from ape to human; tools and mathematics in the ancient world; tools for calculating; and tools in mathematics instruction. The third part opens with a broad review of technology and intellectual trends, circa 1970, and continues with three case studies of approaches in mathematics education and the place of tools in these approaches. The fourth part considers issues related to mathematics instructions: curriculum, assessment and policy; the calculator debate; mathematics in the real world; and teachers' use of technology. The final part looks to the future: task and tool design and new forms of activity via connectivity and computer games.