Mathematical Modeling, Simulations, and Artificial Intelligence for Emergent Pandemic Diseases: Lessons Learned from COVID-19 includes new research, models and simulations developed during the COVID-19 pandemic into how mathematical methods and practice can impact future response. Chapters go beyond forecasting COVID-19, bringing different scale angles and mathematical techniques (e.g., ordinary differential and difference equations, agent-based models, artificial intelligence, and complex networks) which could have potential use in modeling other emergent pandemic diseases. A major part of the book focuses on preparing the scientific community for the next pandemic, particularly the application of mathematical modeling in ecology, economics and epidemiology. Readers will benefit from learning how to apply advanced mathematical modeling to a variety of topics of practical interest, including optimal allocations of masks and vaccines but also more theoretical problems such as the evolution of viral variants. - Provides a comprehensive overview of the state-of-the-art in mathematical modeling and computational simulations for emerging pandemics - Presents modeling techniques that go beyond COVID-19, and that can be applied to tailoring interventions to attenuate high death tolls - Includes illustrations, tables and dialog boxes to explain highly specialized concepts and insights with complex algorithms, along with links to programming code

Mathematical Modeling, Simulations, and Artificial Intelligence for Emergent Pandemic Diseases: Lessons Learned from COVID-19 includes new research, models and simulations developed during the COVID-19 pandemic into how mathematical methods and practice can impact future response. Chapters go beyond forecasting COVID-19, bringing different scale angles and mathematical techniques (e.g., ordinary differential and difference equations, agent-based models, artificial intelligence, and complex networks) which could have potential use in modeling other emergent pandemic diseases. A major part of the book focuses on preparing the scientific community for the next pandemic, particularly the application of mathematical modeling in ecology, economics and epidemiology. Readers will benefit from learning how to apply advanced mathematical modeling to a variety of topics of practical interest, including optimal allocations of masks and vaccines but also more theoretical problems such as the evolution of viral variants. Provides a comprehensive overview of the state-of-the-art in mathematical modeling and computational simulations for emerging pandemics Presents modeling techniques that go beyond COVID-19, and that can be applied to tailoring interventions to attenuate high death tolls Includes illustrations, tables and dialog boxes to explain highly specialized concepts and insights with complex algorithms, along with links to programming code

Based on lecture notes of two summer schools with a mixed audience from mathematical sciences, epidemiology and public health, this volume offers a comprehensive introduction to basic ideas and techniques in modeling infectious diseases, for the comparison of strategies to plan for an anticipated epidemic or pandemic, and to deal with a disease outbreak in real time. It covers detailed case studies for diseases including pandemic influenza, West Nile virus, and childhood diseases. Models for other diseases including Severe Acute Respiratory Syndrome, fox rabies, and sexually transmitted infections are included as applications. Its chapters are coherent and complementary independent units. In order to accustom students to look at the current literature and to experience different perspectives, no attempt has been made to achieve united writing style or unified notation. Notes on some mathematical background (calculus, matrix algebra, differential equations, and probability) have been prepared and may be downloaded at the web site of the Centre for Disease Modeling (www.cdm.yorku.ca).

This volume summarizes the state-of-the-art in the fast growing research area of modeling the influence of information-driven human behavior on the spread and control of infectious diseases. In particular, it features the two main and inter-related “core” topics: behavioral changes in response to global threats, for example, pandemic influenza, and the pseudo-rational opposition to vaccines. In order to make realistic predictions, modelers need to go beyond classical mathematical epidemiology to take these dynamic effects into account. With contributions from experts in this field, the book fills a void in the literature. It goes beyond classical texts, yet preserves the rationale of many of them by sticking to the underlying biology without compromising on scientific rigor. Epidemiologists, theoretical biologists, biophysicists, applied mathematicians, and PhD students will benefit from this book. However, it is also written for Public Health professionals interested in understanding models, and to advanced undergraduate students, since it only requires a working knowledge of mathematical epidemiology.

This book explains how to translate biological assumptions into mathematics to construct useful and consistent models, and how to use the biological interpretation and mathematical reasoning to analyze these models. It shows how to relate models to data through statistical inference, and how to gain important insights into infectious disease dynamics by translating mathematical results back to biology.

This book describes the uses of different mathematical modeling and soft computing techniques used in epidemiology for experiential research in projects such as how infectious diseases progress to show the likely outcome of an epidemic, and to contribute to public health interventions. This book covers mathematical modeling and soft computing techniques used to study the spread of diseases, predict the future course of an outbreak, and evaluate epidemic control strategies. This book explores the applications covering numerical and analytical solutions, presents basic and advanced concepts for beginners and industry professionals, and incorporates the latest methodologies and challenges using mathematical modeling and soft computing techniques in epidemiology. Primary users of this book include researchers, academicians, postgraduate students, and specialists.

In the past half century, deadly disease outbreaks caused by novel viruses of animal origin - Nipah virus in Malaysia, Hendra virus in Australia, Hantavirus in the United States, Ebola virus in Africa, along with HIV (human immunodeficiency virus), several influenza subtypes, and the SARS (sudden acute respiratory syndrome) and MERS (Middle East respiratory syndrome) coronaviruses - have underscored the urgency of understanding factors influencing viral disease emergence and spread. Emerging Viral Diseases is the summary of a public workshop hosted in March 2014 to examine factors driving the appearance, establishment, and spread of emerging, re-emerging and novel viral diseases; the global health and economic impacts of recently emerging and novel viral diseases in humans; and the scientific and policy approaches to improving domestic and international capacity to detect and respond to global outbreaks of infectious disease. This report is a record of the presentations and discussion of the event.

A new edition of a graduate-level machine learning textbook that focuses on the analysis and theory of algorithms. This book is a general introduction to machine learning that can serve as a textbook for graduate students and a reference for researchers. It covers fundamental modern topics in machine learning while providing the theoretical basis and conceptual tools needed for the discussion and justification of algorithms. It also describes several key aspects of the application of these algorithms. The authors aim to present novel theoretical tools and concepts while giving concise proofs even for relatively advanced topics. Foundations of Machine Learning is unique in its focus on the analysis and theory of algorithms. The first four chapters lay the theoretical foundation for what follows; subsequent chapters are mostly self-contained. Topics covered include the Probably Approximately Correct (PAC) learning framework; generalization bounds based on Rademacher complexity and VC-dimension; Support Vector Machines (SVMs); kernel methods; boosting; on-line learning; multi-class classification; ranking; regression; algorithmic stability; dimensionality reduction; learning automata and languages; and reinforcement learning. Each chapter ends with a set of exercises. Appendixes provide additional material including concise probability review. This second edition offers three new chapters, on model selection, maximum entropy models, and conditional entropy models. New material in the appendixes includes a major section on Fenchel duality, expanded coverage of concentration inequalities, and an entirely new entry on information theory. More than half of the exercises are new to this edition.