The third volume of the book series has focused on the use of methotrexate (MTX) for managing rheumatoid arthritis (RA). The book is written with an intention to develop a clinical guide to assist healthcare professionals for using the drug safely and effectively, thereby to improve the prescription practice. In the past two decades, MTX has emerged as the gold standard DAMRD treatment for managing RA. The prescription of MTX has also changed significantly based on the accumulated experience from clinical practice. However, the assessment of the prescription patterns indicates the lack of evidence-based guidelines for prescribing the drug. The guidelines and recommendations provided in this book may help to clarify the uncertainties related to MTX prescription. To improve the patients’ compliance, it is critical that the physician should provide necessary information about the drug to the patient. Additionally, the clinician should have thorough knowledge on managing special circumstances, including the development of drug-related complications. The content includes a brief introduction of the drug, followed by questions and answers explaining different clinical scenarios. The author has attempted to address almost all plausible clinical scenarios involved in the RA management using MTX.

Volume -5 focuses on two drugs ‘Sulfasalazine’ and ‘Hydroxychloroquine’. They have been in clinical use for over 50 years and they were the recommended first choice for managing rheumatoid arthritis prior to the introduction of methotrexate aggressive therapy and pyramidal approach in DMARD prescription. The lack of further studies and probable bias in the clinical trials toward biologics have made these drugs less preferred in routine clinical practice. The present volume provides the most up-to-date information regarding the current status, safety and efficacy, adverse events, and the precautionary measures to be adopted while prescribing these drugs

Rheumatoid arthritis is an inflammatory autoimmune disease, which may result in severe disabilities and deformities if not diagnosed early and managed with adequate dose of DMARDs. The early diagnosis is often impaired by initial atypical presentations and its close mimic to other autoimmune rheumatic diseases. From the point of diagnosis to treatment of the disease, the practicing rheumatologist confronts various challenges. With an intention to address such challenges and to develop a quick reference guide for all clinicians, author started publishing the question and answer series on rheumatoid arthritis since 2012. The answers provided are substantiated by well-accepted guidelines, literature evidence and clinical experience. These answers can assist decision making in diverse clinical circumstances. Author has made a sincere attempt to make the complied volume more scenario-oriented.

Treating an individual patient in majority of circumstances can be guided by protocols, criteria and available evidence-based information. Whenever adequate or suitable literatures are not available, some of the questions are answered based on experience, as well as after discussion with experts. In some circumstances, the answer may not be completely relevant to the clinical scenario of that region and the practice. The current volume is first of the series and has dealt with investigation and evaluation of patients suspected to have RA.

An Aid to the MRCP PACES Volume 3: Station 5 is a brand new, fully updated edition of the best-selling PACES revision guide to address the newest Station, covering Integrated Clinical Assessment, with content guided by the experiences of PACES candidates. The cases and scenarios have been written in accordance with the latest examining and marking schemes used for the exam providing an invaluable training and revision aid for all MRCP PACES candidates. In order to fully support candidates taking the exam, this trilogy of best-selling revision aids is now presented as: An Aid to the MRCP PACES Volume 1: Stations 1 and 3, Fourth Edition 9780470655092 An Aid to the MRCP PACES Volume 2: Stations 2 and 4, Fourth Edition 9780470655184 An Aid to the MRCP PACES Volume 3: Station 5, Fourth Edition 9781118348055

More than 2 million Americans suffer from rheumatoid arthritis. Whether you've been diagnosed with rheumatoid arthritis or care for someone with this disease, 100 Questions & Answers About Arthritis, offers help. Written by a prominent physician, this book provides authoritative, practical answers to 100 of the most common questions asked by arthritis patients, including diagnosis, underlying causes, treatment options, sources of support, and much more.

The seventh volume of the book series focuses on the use of tofacitinib for managing rheumatoid arthritis (RA). The book may serve as a clinical guide to assist healthcare professionals for using the drug safely and effectively, thereby to improve the prescription practice. In the past one decade, tofacitinib has emerged as a potent target synthetic (ts) DMARD for managing RA. The availability of the generic form in global markets has improved its accessibility and clinical use. The drug though very effective in the management of RA, has narrow therapeutic to toxicity ratio. The drug needs to be prescribed with caution. There are set guidelines and pre-introduction evaluation of the drug for safety and probable adverse events. The guidelines and recommendations provided in this book may help to clarify the uncertainties related to tofacitinib prescription. To improve the patient’s compliance, it is critical that the physician provides all the necessary information to the patient. Additionally, the clinician should have thorough knowledge on managing special circumstances, including drug-related complications. The content includes a brief introduction of the drug, followed by questions and answers explaining different clinical scenarios. The author has attempted to address almost all plausible clinical scenarios involved in the RA management using tofacitinib.

The DMARDs discussed in the present volume are second-line drugs used in the management of RA, though they had occupied the first position during the early years of DMARD development. Since the clinical experiences with the drugs like AZA, cyclophosphamide, gold salts, and cyclosporine were good; they were the first treatment of choice during the 70s to 90s. Experience with newer group of DMARDs especially MTX and biologics, have altered the treatment recommendations. However, the clinical experience and evidence regarding the use of these drugs are comparatively lesser. A clear consensus and further exploration of their clinical use may help in re-establishing and defining the role. However, The clinical data suggests that these drugs possess marginal toxicity/therapeutic ratio. the purpose of this book is to introduce these drugs to the readers and facilitate the experts to handle these drugs with extreme caution, since they are often used in RA patients who have extra-articular features or those who are refractory to regularly used DMARDs.

Crash Course - your effective every day study companion PLUS the perfect antidote for exam stress! Save time and be assured you have all the core information you need in one place to excel on your course and achieve exam success. A winning formula now for over 15 years, each volume has been fine tuned and fully updated, with an improved layout tailored to make your life easier. Especially written by junior doctors - those who understand what is essential for exam success - with all information thoroughly checked and quality assured by expert Faculty Advisers, the result is a series of books which exactly meets your needs and you know you can trust. Musculoskeletal problems represent a significant and increasing challenge in primary and secondary care, linked to an aging population, the anticipated obesity epidemic and active sports participation. It is inevitable that all doctors will need to manage patients with orthopaedic and rheumatological problems. Musculoskeletal medicine is a rapidly changing field subject to much clinical and basic science research. This superb new edition provides clear and concise coverage of the diseases that affect the musculoskeletal system and the new understanding that underlies their pathologies and treatments. More than 250 artworks, tables, photographs and boxes present clinical, diagnostic and practical information in an easy-to-follow manner Friendly and accessible approach to the subject makes learning especially easy Written by junior doctors for students - authors who understand exam pressures Contains 'Hints and Tips' boxes, and other useful aide-mémoires Succinct coverage of the subject enables 'sharp focus' and efficient use of time during exam preparation Contains a fully updated self-assessment section - ideal for honing exam skills and self-testing Fully updated self-assessment section - ideal for current examination practice! Includes useful 'Learning Objectives' at the start of each chapter. Pharmacological and disease management information updated in line with current best practice guidelines. Includes recent research findings. Discusses key aspects of patient communication - presented in easy 'Communication' boxes. Fully updated to include feedback from hundreds of students! Crash Course - your effective every day study companion PLUS the perfect antidote for exam stress! Save time and be assured you have all the core information you need in one place to excel on your course and achieve exam success. A winning formula now for over 15 years, each volume has been fine tuned and fully updated, with an improved layout tailored to make your life easier. Especially written by junior doctors - those who understand what is essential for exam success - with all information thoroughly checked and quality assured by expert Faculty Advisers, the result is a series of books which exactly meets your needs and you know you can trust. Musculoskeletal problems represent a significant and increasing challenge in primary and secondary care, linked to an aging population, the anticipated obesity epidemic and active sports participation. It is inevitable that all doctors will need to manage patients with orthopaedic and rheumatological problems. Musculoskeletal medicine is a rapidly changing field subject to much clinical and basic science research. This superb new edition provides clear and concise coverage of the diseases that affect the musculoskeletal system and the new understanding that underlies their pathologies and treatments.

Millions of people are suffering from rheumatoid arthritis (RA) and are looking for pain relief and treatments. Rheumatoid arthritis is a painful and distressing condition that blights the lives of sufferers. The aim of this book is to explain the many different treatments and remedies that are available to sufferers. Arthritis in general and Rheumatoid Arthritis (RA) in particular have stopped making headlines in the newspapers or medical journals for almost two decades now. This doesn't mean that the disease has stopped confronting people or there is somewhat less number of people being affected from it. The truth is people have accepted it as a harsh reality of life and now they are trying to deal with it. This book is aimed for people who want to make necessary adjustments in their life that can enable them to live a full life despite having RA. By learning more about rheumatoid arthritis, it's causes and the steps that can be taken to better manage the condition, the reader can learn about the various methods that are available to treat and manage rheumatoid arthritis more effectively. This is another very informative book by Robert Rymore. He continues with his interest in writing medical educational guides. This guide is intended to be a tool, one that will give you a lot of helpful information and hopefully some pain relief.