T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.

Introductory Immunology quickly acquaints readers with natural immune responses manifesting in diseases and disorders. The book presents a complete picture of natural defenses to infectious agents, as well as the mechanisms that lead to autoimmune dysfunction. In addition, it examines immunologically based diseases, giving the reader sufficient knowledge to make sound clinical decisions leading to better treatment outcomes. Introductory Immunology is aimed at researchers, postgraduates, or any scientifically inclined reader interested in immunology. No prior expertise in medical, biochemical, or cellular science is needed to benefit from the clear presentation of immunology concepts in this book. - Quick, concise introduction to immunological concepts - Breaks down all of immunology into manageable, logically digestible building blocks - Geared toward readers without medical, biochemical, or cellular expertise

Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

Effectively merge basic science and clinical skills with Elsevier’s Integrated Review of Immunology and Microbiology, by Jeffrey K. Actor, PhD. This concise, high-yield title in the popular Integrated Review Series focuses on the core knowledge in immunology and microbiology while linking that information to related concepts from other basic science disciplines. Case-based questions at the end of each chapter enable you to gauge your mastery of the material, and a color-coded format allows you to quickly find the specific guidance you need. . This concise and user-friendly reference provides crucial guidance for the early years of medical training and USMLE preparation. This title includes additional digital media when purchased in print format. For this digital book edition, media content is not included. Spend more time reviewing and less time searching thanks to an extremely focused, "high-yield" presentation. Gauge your mastery of the material and build confidence with case-based and USMLE-style questions that provide effective chapter review and quick practice for your exams. This title includes additional digital media when purchased in print format. For this digital book edition, media content is not included. Grasp and retain vital concepts more easily thanks to a color-coded format, succinct text, key concept boxes, and dynamic illustrations that facilitate learning in a highly visual approach. Effectively review for problem-based courses with the help of text boxes that help you clearly see the clinical relevance of the material.

The 72nd Meeting of the Italian Society of Physiology (SIF) gathers scientists from universities and institutes across Europe and offers a platform for discussing the most exciting developments in the areas of basic and translational physiology. This Frontiers Research Topic will collect varied contributions from original research to review articles from SIF participants covering key achievements and latest advancements in the field of physiology. This collection is led by Guest Editors Prof. Giovanna Valenti, Prof. Andrea Gerbino and Prof. Grazia Tamma from Università degli Studi di Bari Aldo Moro and Prof. Fiorenzo Conti from Università Politecnica delle Marche, Ancona, Italy.

Knowledge of the basic mechanisms of human disease is essential for any student or professional engaged in drug research and development. Functional gene analysis (genomics), protein analysis (proteomics), and other molecular biological techniques have made it possible to understand these cellular processes, opening up exciting opportunities for no