Lipid Metabolism In Signaling Systems
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Author |
: John N. Fain |
Publisher |
: Academic Press |
Total Pages |
: 376 |
Release |
: 2013-10-22 |
ISBN-10 |
: 9781483288321 |
ISBN-13 |
: 1483288323 |
Rating |
: 4/5 (21 Downloads) |
Synopsis Lipid Metabolism in Signaling Systems by : John N. Fain
Many of the phospholipases and even the receptor for inositol 1,4,5-trisphosphate have recently been cloned and sequenced and play an important role in neurotransmission. Methods developed in recent years for the study of the enzymes and intermediates involved in the regulation of neuronal signal transduction involving phospholipid turnover are presented in this volume. - Techniques for examining the role of phosphoinositides in signal transduction - Techniques related to protein kinase C - Analysis of inositol phosphates - Techniques to analyze phospholipid turnover in the brain
Author |
: James M. Ntambi |
Publisher |
: Academic Press |
Total Pages |
: 570 |
Release |
: 2020-08-09 |
ISBN-10 |
: 9780128194058 |
ISBN-13 |
: 0128194057 |
Rating |
: 4/5 (58 Downloads) |
Synopsis Lipid Signaling and Metabolism by : James M. Ntambi
Lipid Signaling and Metabolism provides foundational knowledge and methods to examine lipid metabolism and bioactive lipid signaling mediators that regulate a broad spectrum of biological processes and disease states. Here, world-renowned investigators offer a basic examination of general lipid, metabolism, intracellular lipid storage and utilization that is followed by an in-depth discussion of lipid signaling and metabolism across disease areas, including obesity, diabetes, fatty liver disease, inflammation, cancer, cardiovascular disease and mood-related disorders. Throughout, authors demonstrate how expanding our understanding of lipid mediators in metabolism and signaling enables opportunities for novel therapeutics. Emphasis is placed on bioactive lipid metabolism and research that has been impacted by new technologies and their new potential to transform precision medicine. - Provides a clear, up-to-date understanding of lipid signaling and metabolism and the impact of recent technologies critical to advancing new studies - Empowers researchers to examine bioactive lipid signaling and metabolism, supporting translation to clinical care and precision medicine - Discusses the role of lipid signaling and metabolism in obesity, diabetes, fatty liver disease, inflammation, cancer, cardiovascular disease and mood-related disorders, among others
Author |
: P. Michael Conn |
Publisher |
: |
Total Pages |
: 0 |
Release |
: 1989 |
ISBN-10 |
: OCLC:28963883 |
ISBN-13 |
: |
Rating |
: 4/5 (83 Downloads) |
Synopsis Methods in Neurosciences: Lipid metabolism in signaling systems by : P. Michael Conn
Author |
: Eric J. Murphy |
Publisher |
: CRC Press |
Total Pages |
: 454 |
Release |
: 2010-03-05 |
ISBN-10 |
: 9780849381423 |
ISBN-13 |
: 0849381428 |
Rating |
: 4/5 (23 Downloads) |
Synopsis Lipid-Mediated Signaling by : Eric J. Murphy
As the highly anticipated update to Lipid Second Messengers (CRC Press, 1999), Lipid-Mediating Signaling is a current and comprehensive overview of research methods used in lipid-mediated signal transduction. Pioneering experts provide a much-needed distillation of a decade's worth of advances in research techniques that are pertinent in understand
Author |
: Jose M. Mato |
Publisher |
: CRC Press |
Total Pages |
: 225 |
Release |
: 2018-01-18 |
ISBN-10 |
: 9781351092425 |
ISBN-13 |
: 1351092421 |
Rating |
: 4/5 (25 Downloads) |
Synopsis Phospholipid Metabolism in Cellular Signaling by : Jose M. Mato
Phospholipids are no longer considered exclusively as the building blocks of biomembranes, but are now regarded to be exceptionally important to cellular signalling.Another conclusion resulting from studies over the past several years is that no single general scheme for the role of phospholipids during cell activation can be drawn as representative of all cells. This book presents a comprehensive view of the recent advances made in certain major research areas within the field of phospholipid metabolism in cellular signalling. Topics discussed within this volume include lipid composition of cellular membranes and their organization in biological systems, the dynamic aspects of phospholipid metabolism and its regulation by extracellular stimuli, and the role of newly discovered glycosyl-phosphatidylinositols in insulin action . The book also discusses two biologically active phospholipids: the sphingolipids, and ether-linked glycerophospholipids (the platelet activating factor). Phospholipid Metabolism in Cellular Signaling is an important research reference that should be considered required reading by all scientists and graduate students working on cell activation (e.g., growth factors, hormones, and oncogenes).
Author |
: Alfred H. Merrill |
Publisher |
: Academic Press |
Total Pages |
: 787 |
Release |
: 2000 |
ISBN-10 |
: 9780121822125 |
ISBN-13 |
: 0121822125 |
Rating |
: 4/5 (25 Downloads) |
Synopsis Sphingolipid Metabolism and Cell Signaling by : Alfred H. Merrill
Sphingolipids are found in all eukaryotic and in some prokaryotic organisms and provide structure for cell membranes, lipoproteins, and other biological materials as well as participate in the regulation of cell growth, differentiation, and diverse cell functions, including cell-cell communication, cell-substratum interactions, and intracellular signal transduction. This volume presents methods used in studying enzymes of sphingolipid biosynthesis and turnover, including inhibitors of some of these enzymes, genetic approaches, and organic and enzymatic syntheses of sphingolipids and analogs. Its companion Volume 312 will contain information on analyzing sphingolipids, sphingolipid transport and trafficking, and sphingolipid-protein interactions and cellular targets. The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.
Author |
: |
Publisher |
: Elsevier |
Total Pages |
: 786 |
Release |
: 1999-11-01 |
ISBN-10 |
: 9780080496689 |
ISBN-13 |
: 0080496687 |
Rating |
: 4/5 (89 Downloads) |
Synopsis Sphingolipid Metabolism and Cell Signaling, Part A by :
Sphingolipids are found in all eukaryotic and in some prokaryotic organisms and provide structure for cell membranes, lipoproteins, and other biological materials as well as participate in the regulation of cell growth, differentiation, and diverse cell functions, including cell-cell communication, cell-substratum interactions, and intracellular signal transduction. This volume presents methods used in studying enzymes of sphingolipid biosynthesis and turnover, including inhibitors of some of these enzymes, genetic approaches, and organic and enzymatic syntheses of sphingolipids and analogs. Its companion Volume 312 will contain information on analyzing sphingolipids, sphingolipid transport and trafficking, and sphingolipid-protein interactions and cellular targets.The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.
Author |
: |
Publisher |
: Elsevier |
Total Pages |
: 687 |
Release |
: 2000-10-25 |
ISBN-10 |
: 9780080496696 |
ISBN-13 |
: 0080496695 |
Rating |
: 4/5 (96 Downloads) |
Synopsis Sphingolipid Metabolism and Cell Signaling, Part B by :
This volume contains information on analyzing sphingolipids, sphingolipid transport and trafficking, and sphingolipid-protein interactions and cellular targets. Its companion Volume 311 presents methods used in studying enzymes of sphingolipid biosynthesis and turnover, including inhibitors of some of these enzymes, genetic approaches, and organic and enzymatic syntheses of sphingolipids and analogs. The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.
Author |
: James M. Ntambi, Ph.D. |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 241 |
Release |
: 2013-08-15 |
ISBN-10 |
: 9781461479697 |
ISBN-13 |
: 146147969X |
Rating |
: 4/5 (97 Downloads) |
Synopsis Stearoyl-CoA Desaturase Genes in Lipid Metabolism by : James M. Ntambi, Ph.D.
Obesity and diabetes develop as a complex result of genetic, metabolic and environmental factors and are characterized by increased lipogenesis and lipid accumulation in many tissues. Stearoyl-CoA desaturase (SCD) genes are a critical regulator of lipogenesis and catalyzes the synthesis of monounsaturated fatty acids (MUFA), mainly oleoyl- (18:1n9) and palmitoleoyl-CoA (16:1n7). These MUFAs are the major fatty acid substrates for the synthesis of triglycerides, cholesterol esters, wax esters and membrane phospholipids. There are 4 SCD isoforms (SCD1-4) in mice and two (hSCD1 and hSCD5) expressed in humans. At first glance, stearoyl-CoA desaturase enzyme would be considered a housekeeping enzyme because it synthesizes oleate a well-known fatty acid that is abundant in many dietary sources. However numerous studies have shown that SCD is a very highly regulated enzyme that features in so many physiological processes ranging from fat differentiation, carbohydrate and fat metabolism, inflammation and cancer. The editor’s studies using stearoyl-CoA desaturase knockout (SCD1-/-) mice and studies of other investigators using pharmacological approaches to reduce SCD1 expression in mouse tissues have all established that the expression of SCD1 gene isoform represents a key step in partitioning of lipids between storage and oxidation. High SCD expression favors fat storage leading to obesity while reduced SCD expression favors fat burning and leanness. Although these studies clearly illustrated that SCD1 expression is involved in the development of obesity and insulin resistance, questions remain in the elucidation of the mechanisms involved and role of SCD1. This book includes chapters by leading researchers on SCD Genes in the brain, heart, muscle, liver metabolism, Colitis, and more.
Author |
: Neale Ridgway |
Publisher |
: Elsevier |
Total Pages |
: 625 |
Release |
: 2015-07-24 |
ISBN-10 |
: 9780444634498 |
ISBN-13 |
: 0444634495 |
Rating |
: 4/5 (98 Downloads) |
Synopsis Biochemistry of Lipids, Lipoproteins and Membranes by : Neale Ridgway
Biochemistry of Lipids: Lipoproteins and Membranes, Volume Six, contains concise chapters that cover a wide spectrum of topics in the field of lipid biochemistry and cell biology. It provides an important bridge between broad-based biochemistry textbooks and more technical research publications, offering cohesive, foundational information. It is a valuable tool for advanced graduate students and researchers who are interested in exploring lipid biology in more detail, and includes overviews of lipid biology in both prokaryotes and eukaryotes, while also providing fundamental background on the subsequent descriptions of fatty acid synthesis, desaturation and elongation, and the pathways that lead the synthesis of complex phospholipids, sphingolipids, and their structural variants. Also covered are sections on how bioactive lipids are involved in cell signaling with an emphasis on disease implications and pathological consequences. - Serves as a general reference book for scientists studying lipids, lipoproteins and membranes and as an advanced and up-to-date textbook for teachers and students who are familiar with the basic concepts of lipid biochemistry - References from current literature will be included in each chapter to facilitate more in-depth study - Key concepts are supported by figures and models to improve reader understanding - Chapters provide historical perspective and current analysis of each topic