Cancer is an equal opportunity disease. I have survived three different episodes over the past fourteen years. Strike 1 (1995): One of my radiation oncologists gave me a 50 percent chance of surviving tongue cancer three years disease free. Strike 2 (1997): Neck cancer restarted my recovery clock. Strike 3 (2008): Diagnosed with prostate cancer. Fortunately, Life Constricted isn’t a baseball metaphor. It’s a commentary on a lifelong swimmer and chronicles my family’s struggle with cancer after my dentist detected an abnormality during a routine visit. I owe him and my personal physician my life. They’re the core of my medical dream team. We were forced to retreat from our hurried professional path, typical of twoincome families in the Bay Area. We rearranged our priorities and lived life constricted to pursue its greatest opportunity—love that thrived on hugs, quality time, and laughter. Celebrate our reversal of misfortune. Read Life Constricted.

Tight: Lately, Bryan's been feeling it in all kinds of ways . . . Bryan knows what's tight for him--reading comics, drawing superheroes, and hanging out with no drama. But drama is every day where he's from, and that gets him tight, wound up. And now Bryan's friend Mike pressures him with ideas of fun that are crazy risky. At first, it's a rush following Mike, hopping turnstiles, subway surfing, and getting into all kinds of trouble. But Bryan never really feels right acting so wrong, and drama really isn't him. So which way will he go, especially when his dad tells him it's better to be hard and feared than liked? But if there's one thing Bryan's gotten from his comic heroes, it's that he has power--to stand up for what he feels . . . Torrey Maldonado delivers a fast-paced, insightful, dynamic story capturing urban community life. Readers will connect with Bryan's journey as he navigates a tough world with a heartfelt desire for a different life.

The long-awaited memoir of Booker T. Jones, leader of the famed Stax Records house band, architect of the Memphis soul sound, and one of the most legendary figures in music. From Booker T. Jones's earliest years in segregated Memphis, music was the driving force in his life. While he worked paper routes and played gigs in local nightclubs to pay for lessons and support his family, Jones, on the side, was also recording sessions in what became the famous Stax Studios-all while still in high school. Not long after, he would form the genre-defining group Booker T. and the MGs, whose recordings went on to sell millions of copies, win a place in Rolling Stone's list of top 500 songs of all time, and help forge collaborations with some of the era's most influential artists, including Otis Redding, Wilson Pickett, and Sam & Dave. Nearly five decades later, Jones's influence continues to help define the music industry, but only now is he ready to tell his remarkable life story. Time is Tight is the deeply moving account of how Jones balanced the brutality of the segregationist South with the loving support of his family and community, all while transforming a burgeoning studio into a musical mecca. Culminating with a definitive account into the inner workings of the Stax label, as well as a fascinating portrait of working with many of the era's most legendary performers-Bob Dylan, Willie Nelson, and Tom Jones, among them-this extraordinary memoir promises to become a landmark moment in the history of Southern Soul.

2023 College Theology Society Best Book Award 2023 Catholic Media Association Third Place Award, Theology – Morality, Ethics, Christology, Mariology, and Redemption 2023 Association of Catholic Publishers Second Place Award, Theology Dust in the Blood considers the harrowing realities of life with depression from a Christian theological perspective. In conversation with popular Christian theologies of depression that justify why this suffering exists and prescribe how people ought to relate to it, Jessica Coblentz offers another Christian approach to this condition: she reflects on depression as a wilderness experience. Weaving first-person narratives of depression, contemporary theologies of suffering, and ancient biblical tales of the wilderness, especially the story of Hagar, Coblentz argues for and contributes to an expansion of Christian ideas about what depression is, how God relates to it, and how Christians should understand and respond to depression in turn.

NEW YORK TIMES BESTSELLER • The award-winning book that inspired an Apple Original series from Apple TV+ • A landmark investigation of patient deaths at a New Orleans hospital ravaged by Hurricane Katrina—and the suspenseful portrayal of the quest for truth and justice—from a Pulitzer Prize–winning physician and reporter “An amazing tale, as inexorable as a Greek tragedy and as gripping as a whodunit.”—Dallas Morning News After Hurricane Katrina struck and power failed, amid rising floodwaters and heat, exhausted staff at Memorial Medical Center designated certain patients last for rescue. Months later, a doctor and two nurses were arrested and accused of injecting some of those patients with life-ending drugs. Five Days at Memorial, the culmination of six years of reporting by Pulitzer Prize winner Sheri Fink, unspools the mystery, bringing us inside a hospital fighting for its life and into the most charged questions in health care: which patients should be prioritized, and can health care professionals ever be excused for hastening death? Transforming our understanding of human nature in crisis, Five Days at Memorial exposes the hidden dilemmas of end-of-life care and reveals how ill-prepared we are for large-scale disasters—and how we can do better. ONE OF THE TEN BEST BOOKS OF THE YEAR: The New York Times Book Review • ONE OF THE BEST BOOKS OF THE YEAR: Chicago Tribune, Seattle Times, Entertainment Weekly, Christian Science Monitor, Kansas City Star WINNER: National Book Critics Circle Award, J. Anthony Lukas Book Prize, PEN/John Kenneth Galbraith Award, Los Angeles Times Book Prize, Ridenhour Book Prize, American Medical Writers Association Medical Book Award, National Association of Science Writers Science in Society Award

The eloquent voices in Holiday Tight, Letting Go speak of different reality; that women with metastatic breast cancer generally go on to live with their disease, often for many years, and that the time they have can be full and meaningful. All aspects of dealing with the disease are covered here: coping with the shock of recurrence, seeking information, making treatment decisions, and communicating effectively with medical personnel. Getting emotional support from other patients and friends and working on relationship and family issues are often as important as managing the side-effects of treatment and the pain and symptoms of disease progression. Open discussions about approaching the end of life often lead to a profound inquiry into ways of keeping hope alive and finding meaning in the midst of adversity. Frank and moving descriptions from forty women and men who have been there make their stories relevant to anyone facing a life-threatening illness.

The coveted “Made in Italy” label calls to mind visions of nimble-fingered Italian tailors lovingly sewing elegant, high-end clothing. The phrase evokes a sense of authenticity, heritage, and rustic charm. Yet, as Elizabeth L. Krause uncovers in Tight Knit, Chinese migrants are the ones sewing “Made in Italy” labels into low-cost items for a thriving fast-fashion industry—all the while adding new patterns to the social fabric of Italy’s iconic industry. Krause offers a revelatory look into how families involved in the fashion industry are coping with globalization based on longterm research in Prato, the historic hub of textile production in the heart of metropolitan Tuscany. She brings to the fore the tensions—over value, money, beauty, family, care, and belonging—that are reaching a boiling point as the country struggles to deal with the same migration pressures that are triggering backlash all over Europe and North America. Tight Knit tells a fascinating story about the heterogeneity of contemporary capitalism that will interest social scientists, immigration experts, and anyone curious about how globalization is changing the most basic of human conditions—making a living and making a life.

This e-book will review special features of the cerebral circulation and how they contribute to the physiology of the brain. It describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high metabolic demands and the need for tight water and ion homeostasis. Autoregulation is pronounced in the brain, with myogenic, metabolic and neurogenic mechanisms contributing to maintain relatively constant blood flow during both increases and decreases in pressure. In addition, unlike peripheral organs where the majority of vascular resistance resides in small arteries and arterioles, large extracranial and intracranial arteries contribute significantly to vascular resistance in the brain. The prominent role of large arteries in cerebrovascular resistance helps maintain blood flow and protect downstream vessels during changes in perfusion pressure. The cerebral endothelium is also unique in that its barrier properties are in some way more like epithelium than endothelium in the periphery. The cerebral endothelium, known as the blood-brain barrier, has specialized tight junctions that do not allow ions to pass freely and has very low hydraulic conductivity and transcellular transport. This special configuration modifies Starling's forces in the brain microcirculation such that ions retained in the vascular lumen oppose water movement due to hydrostatic pressure. Tight water regulation is necessary in the brain because it has limited capacity for expansion within the skull. Increased intracranial pressure due to vasogenic edema can cause severe neurologic complications and death.

As the work of thinkers such as Michel Foucault, Fran ois Jacob, Louis Althusser, and Pierre Bourdieu demonstrates, Georges Canguilhem has exerted tremendous influence on the philosophy of science and French philosophy more generally. In Knowledge of Life, a book that spans twenty years of his essays and lectures, Canguilhem offers a series of epistemological histories that seek to establish and clarify the stakes, ambiguities, and emergence of philosophical and biological concepts that defined the rise of modern biology. How do transformations in biology and modern medicine shape conceptions of life? How do philosophical concepts feed into biological ideas and experimental practices, and how are they themselves transformed? How does knowledge "undo the experience of life so as to help man remake what life has made without him, in him or outside of him?" Knowledge of Life is Canguilhem's effort to explain how the movements of knowledge and life come to rest upon each other. Published at the dawn of the genetic revolution and still pertinent today, the book tackles the history of cell theory, the conceptual moves toward and away from mechanical understandings of the organism, the persistence of vitalism, and the nature of normality in science and its objects.

In a culture obsessed with happiness, this wise, stirring book points the way toward a richer, more satisfying life. Too many of us believe that the search for meaning is an esoteric pursuit—that you have to travel to a distant monastery or page through dusty volumes to discover life’s secrets. The truth is, there are untapped sources of meaning all around us—right here, right now. To explore how we can craft lives of meaning, Emily Esfahani Smith synthesizes a kaleidoscopic array of sources—from psychologists, sociologists, philosophers, and neuroscientists to figures in literature and history such as George Eliot, Viktor Frankl, Aristotle, and the Buddha. Drawing on this research, Smith shows us how cultivating connections to others, identifying and working toward a purpose, telling stories about our place in the world, and seeking out mystery can immeasurably deepen our lives. To bring what she calls the four pillars of meaning to life, Smith visits a tight-knit fishing village in the Chesapeake Bay, stargazes in West Texas, attends a dinner where young people gather to share their experiences of profound loss, and more. She also introduces us to compelling seekers of meaning—from the drug kingpin who finds his purpose in helping people get fit to the artist who draws on her Hindu upbringing to create arresting photographs. And she explores how we might begin to build a culture that leaves space for introspection and awe, cultivates a sense of community, and imbues our lives with meaning. Inspiring and story-driven, The Power of Meaning will strike a profound chord in anyone seeking a life that matters.