With the interest in biomarkers available for diagnostic, therapeutic, prognostic and research applications growing rapidly, it is now expected that every pathologist should be aware of the correct application of immunohistochemistry in daily practice. This fully updated fourth edition provides practical guidance about preparation, key uses and pitfalls of antibodies for immunohistology in a unique A-Z format. Seventeen full colour infographics present detail about specific biomarkers, including FOXL2, GATA3 and SOX10, pulling out information about expression in tissues and prognosis. Expanded with new biomarkers and the removal of biomarkers that are no longer in common use, each entry in this concise new edition follows a standard structure for quick and easy access by busy readers.

Revised edition of: Leong's manual of diagnostic antibodies for immunohistology / edited by Runjan Chetty, Kumarasen Cooper, Allen Gown. Third edition. 2016.

A detailed, A-Z guide and an indispensable source for pathologists ensuring correct application of immunohistochemistry in daily practice.

This book provides a comprehensive and up-to-date listing of the sources of immunochemicals for use in laboratory-based specialties such as Histopathology. Much more than just a catalogue of these chemicals, it includes specific technical details on the application and specificities of antisera, common pitfalls in use and how to avoid them, an aspect not covered in other similar texts.

The rapid acceptance of immunohistochemistry as an important and even indispensable adjunct to morphological examination and diagnosis requires the modern anatomical pathology laboratory to be conversant with, and proficient in, immunostaining procedures, as well as methods of tissue processing and antigen retrieval and the underlying characteristics of the increasing number of antibodies and antisera available. This fully revised, expanded and updated edition provides a comprehensive list of antisera and monoclonal antibodies that have useful diagnostic applications in tissue sections and cell preparations. Various clones, which are commercially available to detect the same antigen, are listed and the sensitivities and specificities of the antibodies are discussed. Importantly, the authors, all pathologists with a wealth of experience in immunostaining procedures, provide fully referenced details and expert advice on each reagent, with the reader will find invaluable. Finally, the appendices provide easily accessible and clear summaries of selected antibody panels for specific diagnostic situations, details of heat-induced antigen/epitope retrieval (including the use of microwaves) and a useful reference to the websites of the main antibody suppliers.

Since the publication of the first edition of this best-selling book in 2009, the field of immunohistochemistry has advanced significantly. Fully updated to reflect the latest developments in the field, Modern Immunohistochemistry, Second Edition, is a practical guide to all the important diagnostic markers in each organ system. Concise text is supplemented by over 1,100 high-quality colour images and algorithms. The new edition features even more summary tables, highlighting the key points of differential immunophenotypic panels. A new, expanded introduction explains the basic principles of immunohistochemistry, and chapters have been updated to incorporate predictive/prognostic markers and the latest WHO classifications. All chapters are written by the same expert authors, providing a consistent, engaging style throughout and avoiding contradictory advice. An essential text for residents, this is also an extremely valuable resource for practitioners in anatomic pathology wishing to familiarise themselves with diagnostic markers at a quick glance.

17 world-renowned experts offer the most current information and reliable guidance on immunohistochemical diagnoses in surgical pathology and cytopathology. Introductory chapters cover cost modeling for immunohistochemistry and immunohistochemical techniques. The following chapters utilize an organ systems and diseases approach to diagnostic tumor pathology. "A newly updated book that our laboratory staff have found very useful in our day to day work" Reviewed by: PathLab.org, Sept 2014 "...It also acts as an up-to-date bench-top reference tool. It is an easy-to-read, wellpresented text that I would recommend as a 'must have' for every pathology department". Reviewed by: Dr Gemma Petts, Imperial College London on behalf of The Bulletin of The Royal College of Pathologists, Oct 2014 Consistently organized chapters for quick access to vital information Each chapter "stands alone," providing all the information you might need on a specific topic Quick-reference boxes summarize the most important diagnostic points at the end of each text Section Colour photographs and illustrations reinforce key diagnostic points

The Handbook of Mental Health and Aging, Third Edition provides a foundational background for practitioners and researchers to understand mental health care in older adults as presented by leading experts in the field. Wherever possible, chapters integrate research into clinical practice. The book opens with conceptual factors, such as the epidemiology of mental health disorders in aging and cultural factors that impact mental health. The book transitions into neurobiological-based topics such as biomarkers, age-related structural changes in the brain, and current models of accelerated aging in mental health. Clinical topics include dementia, neuropsychology, psychotherapy, psychopharmacology, mood disorders, anxiety, schizophrenia, sleep disorders, and substance abuse. The book closes with current and future trends in geriatric mental health, including the brain functional connectome, repetitive transcranial magnetic stimulation (rTMS), technology-based interventions, and treatment innovations. - Identifies factors influencing mental health in older adults - Includes biological, sociological, and psychological factors - Reviews epidemiology of different mental health disorders - Supplies separate chapters on grief, schizophrenia, mood, anxiety, and sleep disorders - Discusses biomarkers and genetics of mental health and aging - Provides assessment and treatment approaches