Lactams—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Caprolactam. The editors have built Lactams—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Caprolactam in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Lactams—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

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Due to their medicinal activity and potential use as synthetic starting materials, studies on beta-lactams have increased significantly. This unique volume takes readers on a tour de force from the concept of antibiosis to the serendipity of antibiotics, evolution of beta‐lactam development, and molecular biology of antibiotic resistance. These areas of research have culminated in a deeper understanding of microbiology, particularly in the area of bacterial cell wall synthesis and recycling. Considerable work has been performed by chemists and biologists to continue updating their findings about beta-lactam synthesis. Features: Stereoselective synthesis of monocyclic, bicyclic, and polycyclic beta-lactams Microwave, ultrasound, and solid support-mediated preparation of beta-lactams Diverse medicinal activities including anticancer activities of beta-lactams and products obtained from them Nanoparticles, artificial intelligence, and dipole moments in beta-lactam science Synthesis and mechanism of formation of polyaromatic beta-lactams

This new volume provides the most updated information about beta-lactams relating to both the pharmaceutical industry and synthetic chemistry. It provides the antibiotic activities as well as chemical reactivities of beta-lactams, which are important because they are commonly applied as antibiotics in the treatment of bacterial infections. The volume provides comprehensive coverage of most of the known beta-lactam antibiotics with both structural and biological information, antibiotic mechanisms, self-defense mechanisms of bacteria, nearly all known synthetic methods for the preparation of beta-lactams, and possible reactions in which beta-lactams can participate. Key features: Provides the most comprehensive collection of beta-lactam antibiotics (up to 269 molecules) with chemical structures, CAS number, IUPAC names and associated biological activities attached Offers a comprehensive and detailed collection of beta-lactamase databases Explains the self-defense mechanisms of bacteria for surviving, including the formation of biofilm and conversion into L-form and secretion of beta-lactamase to deactivate the beta-lactam antibiotics Provides a comprehensive survey on the synthetic methods to make beta-lactams Gives all of the possible reactions involving beta-lactams as the starting materials Surveys over 1000 research works and includes all available DOI information The volume is a valuable resource on the antibiotic activities as well as chemical reactivities of beta-lactams for researchers and scientists, faculty, and advanced students, as well as for industry professionals working in medicinal and pharmaceutical chemistry, organic chemistry, organic synthesis, heterocycles, proteins and peptides.

Today's drug research is an extremely complex process which, apart from chemistry, pharmacology, toxicology and preclinical trials, in cludes a variety of sciences such as biotechnology, biochemistry, im munology, physics, biology and even computer sciences. The Table of Contents of the present volume demonstrates this situation and makes it evident that the individual researcher cannot possibly hope to keep abreast of all aspects of modern drug research. In this re spect, the series of monographs "Progress in Drug Research" pro vides valuable help and assistance. Those who simply wish to remain informed of the latest trends and developments in drug research can use the 34 volumes so far available as a source of almost encyclo pedic character. Researchers actively engaged in the various scientific fields forming the entity of drug research can benefit from the wealth of knowledge and experience of the respective authors, and they will be assisted in their endeavour to discover new pharmaceutical agents. Moreover, the extensive bibliographies of the individual reviews provide an invaluable overview of the literature most pertinent to today's drug research. I should like to thank all the authors for their willingness to prepare the reviews and for sharing their insights and experience with the readers. Thanks are also due to Mrs L. Koechlin, H.-P. Thiir and A. Gomm of Birkhauser Publishers for their valuable help in the pre paration of this volume.

Frontiers in Clinical Drug Research – Anti infectives is an eBook series that brings updated reviews to readers interested in learning about advances in the development of pharmaceutical agents for the treatment of infectious diseases. The scope of the eBook series covers a range of topics including the chemistry, pharmacology, molecular biology and biochemistry of natural and synthetic drugs employed in the treatment of infectious diseases. Reviews in this series also include research on multi drug resistance and pre-clinical / clinical findings on novel antibiotics, vaccines, antifungal agents and antitubercular agents. Frontiers in Clinical Drug Research – Anti infectives is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in the field of anti-infective drug discovery and epidemiology. The second volume of this series features reviews that cover a variety of topics including: -Identification of nosocomial pathogens and antimicrobials using phenotypic techniques -Topical antimicrobials -Anti-infective drug safety -Antimicrobial resistance … and much more.