Kinetics Of Enzyme Action
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Author |
: Ross L. Stein |
Publisher |
: John Wiley & Sons |
Total Pages |
: 322 |
Release |
: 2011-08-08 |
ISBN-10 |
: 9781118084403 |
ISBN-13 |
: 1118084403 |
Rating |
: 4/5 (03 Downloads) |
Synopsis Kinetics of Enzyme Action by : Ross L. Stein
Few scientists have the knowledge to perform the studies that are necessary to discover and characterize enzyme inhibitors, despite the vested interest the pharmaceutical industry has in this field. Beginning with the most basic principles pertaining to simple, one-substrate enzyme reactions and their inhibitors, and progressing to a thorough treatment of two-substrate enzymes, Kinetics of Enzyme Action: Essential Principles for Drug Hunters provides biochemists, medicinal chemists, and pharmaceutical scientists with numerous case study examples to outline the tools and techniques necessary to perform, understand, and interpret detailed kinetic studies for drug discovery.
Author |
: Keith James Laidler |
Publisher |
: Oxford : Clarendon Press |
Total Pages |
: 482 |
Release |
: 1973 |
ISBN-10 |
: MINN:31951000005353J |
ISBN-13 |
: |
Rating |
: 4/5 (3J Downloads) |
Synopsis The Chemical Kinetics of Enzyme Action by : Keith James Laidler
Author |
: Daniel L. Purich |
Publisher |
: Elsevier |
Total Pages |
: 915 |
Release |
: 2010-06-16 |
ISBN-10 |
: 9780123809254 |
ISBN-13 |
: 0123809258 |
Rating |
: 4/5 (54 Downloads) |
Synopsis Enzyme Kinetics: Catalysis and Control by : Daniel L. Purich
Far more than a comprehensive treatise on initial-rate and fast-reaction kinetics, this one-of-a-kind desk reference places enzyme science in the fuller context of the organic, inorganic, and physical chemical processes occurring within enzyme active sites. Drawing on 2600 references, Enzyme Kinetics: Catalysis & Control develops all the kinetic tools needed to define enzyme catalysis, spanning the entire spectrum (from the basics of chemical kinetics and practical advice on rate measurement, to the very latest work on single-molecule kinetics and mechanoenzyme force generation), while also focusing on the persuasive power of kinetic isotope effects, the design of high-potency drugs, and the behavior of regulatory enzymes. - Historical analysis of kinetic principles including advanced enzyme science - Provides both theoretical and practical measurements tools - Coverage of single molecular kinetics - Examination of force generation mechanisms - Discussion of organic and inorganic enzyme reactions
Author |
: Athel Cornish-Bowden |
Publisher |
: Elsevier |
Total Pages |
: 221 |
Release |
: 2014-05-20 |
ISBN-10 |
: 9781483164670 |
ISBN-13 |
: 1483164675 |
Rating |
: 4/5 (70 Downloads) |
Synopsis Principles of Enzyme Kinetics by : Athel Cornish-Bowden
Principles of Enzyme Kinetics discusses the principles of enzyme kinetics at an intermediate level. It is primarily written for first-year research students in enzyme kinetics. The book is composed of 10 chapters. Chapter 1 provides the basic principles of enzyme kinetics with a brief discussion of dimensional analysis. Subsequent chapters cover topics on the essential characteristics of steady-state kinetics, temperature dependence, methods for deriving steady-state rate equations, and control of enzyme activity. Integrated rate equations, and introductions to the study of fast reactions and the statistical aspects of enzyme kinetics are provided as well. Chemists and biochemists will find the book invaluable.
Author |
: Antonio Baici |
Publisher |
: Springer |
Total Pages |
: 503 |
Release |
: 2015-06-24 |
ISBN-10 |
: 9783709114025 |
ISBN-13 |
: 3709114020 |
Rating |
: 4/5 (25 Downloads) |
Synopsis Kinetics of Enzyme-Modifier Interactions by : Antonio Baici
The kinetic mechanisms by which enzymes interact with inhibitors and activators, collectively called modifiers, are scrutinized and ranked taxonomically into autonomous species in a way similar to that used in the biological classification of plants and animals. The systematization of the mechanisms is based on two fundamental characters: the allosteric linkage between substrate and modifier and the factor by which a modifier affects the catalytic constant of the enzyme. Combinations of the physically significant states of these two characters in an ancestor-descendant-like fashion reveal the existence of seventeen modes of interaction that cover the needs of total, partial and fine-tuning modulation of enzyme activity. These interactions comprise five linear and five hyperbolic inhibition mechanisms, five nonessential activation mechanisms and two hybrid species that manifest either hyperbolic inhibition or nonessential activation characteristics depending on substrate concentration. Five essential activation mechanisms, which are taxonomically independent of the mentioned basic species, complete the inventory of enzyme modifiers. Often masked under conventional umbrella terms or treated as anomalous cases, all seventeen basic inhibition and nonessential activation mechanisms are represented in the biochemical and pharmacological literature of this and the past century, either in the form of rapid or slow-onset reversible interactions, or as irreversible modification processes. The full potential of enzyme inhibitors and activators can only be appreciated after elucidating the details of their kinetic mechanisms of action exploring the entire range of physiologically significant reactant concentrations. This book highlights the wide spectrum of allosteric enzyme modification in physiological occurrences as well as in pharmacological and biotechnological applications that embrace simple and multiple enzyme-modifier interactions. The reader is guided in the journey through this still partly uncharted territory with the aid of mechanistically-oriented criteria aimed at showing the logical way towards the identification of a particular mechanism.
Author |
: Raymond Chang |
Publisher |
: University Science Books |
Total Pages |
: 706 |
Release |
: 2005-02-11 |
ISBN-10 |
: 1891389335 |
ISBN-13 |
: 9781891389337 |
Rating |
: 4/5 (35 Downloads) |
Synopsis Physical Chemistry for the Biosciences by : Raymond Chang
This book is ideal for use in a one-semester introductory course in physical chemistry for students of life sciences. The author's aim is to emphasize the understanding of physical concepts rather than focus on precise mathematical development or on actual experimental details. Subsequently, only basic skills of differential and integral calculus are required for understanding the equations. The end-of-chapter problems have both physiochemical and biological applications.
Author |
: Irwin H. Segel |
Publisher |
: |
Total Pages |
: 957 |
Release |
: 2014 |
ISBN-10 |
: 8126548150 |
ISBN-13 |
: 9788126548156 |
Rating |
: 4/5 (50 Downloads) |
Synopsis Enzyme Kinetics by : Irwin H. Segel
Author |
: Robert A. Copeland |
Publisher |
: John Wiley & Sons |
Total Pages |
: 416 |
Release |
: 2004-04-07 |
ISBN-10 |
: 9780471461852 |
ISBN-13 |
: 0471461857 |
Rating |
: 4/5 (52 Downloads) |
Synopsis Enzymes by : Robert A. Copeland
Fully updated and expanded-a solid foundation for understandingexperimental enzymology. This practical, up-to-date survey is designed for a broadspectrum of biological and chemical scientists who are beginning todelve into modern enzymology. Enzymes, Second Editionexplains the structural complexities of proteins and enzymes andthe mechanisms by which enzymes perform their catalytic functions.The book provides illustrative examples from the contemporaryliterature to guide the reader through concepts and data analysisprocedures. Clear, well-written descriptions simplify the complexmathematical treatment of enzyme kinetic data, and numerouscitations at the end of each chapter enable the reader to accessthe primary literature and more in-depth treatments of specifictopics. This Second Edition of Enzymes: A Practical Introductionto Structure, Mechanism, and Data Analysis features refinedand expanded coverage of many concepts, while retaining theintroductory nature of the book. Important new featuresinclude: A new chapter on protein-ligand binding equilibria Expanded coverage of chemical mechanisms in enzyme catalysisand experimental measurements of enzyme activity Updated and refined discussions of enzyme inhibitors andmultiple substrate reactions Coverage of current practical applications to the study ofenzymology Supplemented with appendices providing contact information forsuppliers of reagents and equipment for enzyme studies, as well asa survey of useful Internet sites and computer software forenzymatic data analysis, Enzymes, Second Edition isthe ultimate practical guide for scientists and students inbiochemical, pharmaceutical, biotechnical, medicinal, andagricultural/food-related research.
Author |
: Robert A. Alberty |
Publisher |
: John Wiley & Sons |
Total Pages |
: 482 |
Release |
: 2006-03-31 |
ISBN-10 |
: 9780470036457 |
ISBN-13 |
: 0470036451 |
Rating |
: 4/5 (57 Downloads) |
Synopsis Biochemical Thermodynamics by : Robert A. Alberty
Navigate the complexities of biochemical thermodynamics with Mathematica(r) Chemical reactions are studied under the constraints of constant temperature and constant pressure; biochemical reactions are studied under the additional constraints of pH and, perhaps, pMg or free concentrations of other metal ions. As more intensive variables are specified, more thermodynamic properties of a system are defined, and the equations that represent thermodynamic properties as a function of independent variables become more complicated. This sequel to Robert Alberty's popular Thermodynamics of Biochemical Reactions describes how researchers will find Mathematica(r) a simple and elegant tool, which makes it possible to perform complex calculations that would previously have been impractical. Biochemical Thermodynamics: Applications of Mathematica(r) provides a comprehensive and rigorous treatment of biochemical thermodynamics using Mathematica(r) to practically resolve thermodynamic issues. Topics covered include: * Thermodynamics of the dissociation of weak acids * Apparent equilibrium constants * Biochemical reactions at specified temperatures and various pHs * Uses of matrices in biochemical thermodynamics * Oxidoreductase, transferase, hydrolase, and lyase reactions * Reactions at 298.15K * Thermodynamics of the binding of ligands by proteins * Calorimetry of biochemical reactions Because Mathematica(r) allows the intermingling of text and calculations, this book has been written in Mathematica(r) and includes a CD-ROM containing the entire book along with macros that help scientists and engineers solve their particular problems.
Author |
: Larry Engelking |
Publisher |
: Academic Press |
Total Pages |
: 789 |
Release |
: 2014-08-12 |
ISBN-10 |
: 9780123919106 |
ISBN-13 |
: 012391910X |
Rating |
: 4/5 (06 Downloads) |
Synopsis Textbook of Veterinary Physiological Chemistry by : Larry Engelking
Bridging the gap between basic and clinical science concepts, the Textbook of Veterinary Physiological Chemistry, Third Edition offers broad coverage of biochemical principles for students and practitioners of veterinary medicine. The only recent biochemistry book written specifically for the veterinary field, this text covers cellular-level concepts related to whole-body physiologic processes in a reader-friendly, approachable manner. Each chapter is written in a succinct and concise style that includes an overview summary section, numerous illustrations for best comprehension of the subject matter, targeted learning objectives, and end of the chapter study questions to assess understanding. With new illustrations and an instructor website with updated PowerPoint images, the Textbook of Veterinary Physiological Chemistry, Third Edition, proves useful to students and lecturers from diverse educational backgrounds. Sectional exams and case studies, new to this edition, extend the breadth and depth of learning resources. - Provides newly developed case studies that demonstrate practical application of concepts - Presents comprehensive sectional exams for self-assessment - Delivers instructor website with updated PowerPoint images and lecture slides to enhance teaching and learning - Employs a succinct communication style in support of quick comprehension