Ion Channel Diseases

Ion Channel Diseases
Author :
Publisher : Academic Press
Total Pages : 168
Release :
ISBN-10 : 9780080923109
ISBN-13 : 0080923100
Rating : 4/5 (09 Downloads)

Synopsis Ion Channel Diseases by :

Ion channel dysfunction in humans leads to impairment of the excitable processes necessary for the normal function of several tissues, such as muscle and brain. It follows that an increasing number of human diseases have been associated with malfunctioning ion channels, many of which have a genetic component. This volume of Advances in Genetics presents a broad and comprehensive overview of the inherited channelopathies in humans, including clinical, genetic and molecular aspects of these conditions. Keeping true to the scope of the serial, novel genomic and modeling research approaches and a review of potential therapeutic approaches for each of these conditions are also incorporated.

Ion Channels and Disease

Ion Channels and Disease
Author :
Publisher : Academic Press
Total Pages : 505
Release :
ISBN-10 : 9780080535210
ISBN-13 : 0080535216
Rating : 4/5 (10 Downloads)

Synopsis Ion Channels and Disease by : Frances M. Ashcroft

Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. - Introduces the relevant aspects of molecular biology and biophysics - Describes the principal methods used to study channelopathies - Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function - Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype

Handbook of Ion Channels

Handbook of Ion Channels
Author :
Publisher : CRC Press
Total Pages : 682
Release :
ISBN-10 : 9781466551428
ISBN-13 : 1466551429
Rating : 4/5 (28 Downloads)

Synopsis Handbook of Ion Channels by : Jie Zheng

The New Benchmark for Understanding the Latest Developments of Ion ChannelsIon channels control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli, and regulate the response to physical stimuli. They can often interact with the cellular environment due to their location at the surface of ce

Channelopathies

Channelopathies
Author :
Publisher : Elsevier
Total Pages : 383
Release :
ISBN-10 : 9780080528854
ISBN-13 : 0080528856
Rating : 4/5 (54 Downloads)

Synopsis Channelopathies by : F. Lehmann-Horn

This book describes human hereditary ion channel diseases of voltage- and ligand-gated ion channels covering the diverse fields of medicine myology, neurology, cardiology, and nephrology requiring a wide and interdisciplinary readership. Interesting parallels in pathogenetic mechanisms of disease are especially emphasized to interest even highly specialized readers in entities outside of their fields. Each author has written an objective overview of his or her particular subject in a way that should allow the reader within a short period of time to obtain a comprehensive picture of the present state of art.

Ion Channels

Ion Channels
Author :
Publisher : Cambridge University Press
Total Pages : 324
Release :
ISBN-10 : 0521498821
ISBN-13 : 9780521498821
Rating : 4/5 (21 Downloads)

Synopsis Ion Channels by : David J. Aidley

Ion channels are crucial components of living cells. Situated in the cell's membranes. they allow particular ions to pass from one side of the membrane to the other. In recent years the patch clamp technique has allowed the activity of individual channels to be measured, and recombinant DNA technology has led to fascinating detail on their structure. Together, these technical advances have produced a great flowering of knowledge and understanding about the subject, itself leading to further breakthroughs in science and medicine. Ion Channels provides an introduction to this scientific endeavour. It emphasises the molecular structure of channels as determined by gene cloning technology. This knowledge illuminates discussions of the permeability and selectivity of channels, their gating and modulation, their responses to drugs and toxins and the human diseases caused when they do not function properly.

Ion Channels

Ion Channels
Author :
Publisher :
Total Pages : 586
Release :
ISBN-10 : 9780199296750
ISBN-13 : 0199296758
Rating : 4/5 (50 Downloads)

Synopsis Ion Channels by : James N. C. Kew

Ion channels are intimately involved in the everyday physiological functions that enable us to live a full and varied life. When disease strikes, malfunction of ion channels or their dependent is often involved, either as the cause or the effect of the illness. Thus, billions of dollars have been, and still are being, invested in research to understand the physiological and pathophysiological functions of ion channels in an attempt to develop novel therapeutic treatments for a wide range of diseases. This book provides a comprehensive overview of ion channel structure and function. It comprises two major parts. Part one is an introductory overview of the ion channel superfamily and the generic aspects of ion channel function. This part also reviews the methodologies by which ion channel function can be studied from the perspective of performing detailed biophysical characterization through to the deployment of high throughput approaches for identifying novel ion channel ligands. Part two of the book provides an in-depth review of the individual ion channel subfamilies and, as such, is subdivided into four broad sections: Voltage-Gated Ion Channels, Extracellular Ligand-Gated Ion Channels, Intracellular Ligand-Gated Ion Channels, and Polymodal-Gated Ion Channels, with each chapter focused on specific family members. These chapters have been written by world leading experts and provide a detailed overview of the structure, biophysics, localization, pharmacology, physiology, and disease relevance of each particular ion channel subfamily. Reviewing both the basic principles of ion channel function and providing a detailed up-to-date review of the phsyiological and pharmacological aspects of individual ion channel sub-families, this book constitutes both an excellent introduction to the field for non-specialists, as well as a highly valuable reference text for experienced researchers already working in the ion channel area.

Neuromuscular Disorders: Management and Treatment E-Book

Neuromuscular Disorders: Management and Treatment E-Book
Author :
Publisher : Elsevier Health Sciences
Total Pages : 469
Release :
ISBN-10 : 9781437736403
ISBN-13 : 1437736408
Rating : 4/5 (03 Downloads)

Synopsis Neuromuscular Disorders: Management and Treatment E-Book by : Tulio E. Bertorini

Neuromuscular Disorders presents a multi-disciplinary approach to the management and therapeutic treatment of the full range of neuromuscular disorders and resulting complications. Dr. Tulio Bertorini and a contributing team of the world’s leading authorities in the field provide the latest tools and strategies for minimizing disability and maximizing quality of life. Effectively treat your patients using the latest management tools and targeted therapeutic strategies. Manage all neuromuscular disorders as well as resulting complications through comprehensive coverage of diagnosis and evaluations, treatments, and outcomes. Apply the multi-disciplinary approach of an expert in clinical neuromuscular care and a team of world-renown contributors. Easily refer to tools for diagnosis, treatment algorithms, and drug tables included throughout the text.

Calcium Entry Channels in Non-Excitable Cells

Calcium Entry Channels in Non-Excitable Cells
Author :
Publisher : CRC Press
Total Pages : 343
Release :
ISBN-10 : 9781498752732
ISBN-13 : 149875273X
Rating : 4/5 (32 Downloads)

Synopsis Calcium Entry Channels in Non-Excitable Cells by : Juliusz Ashot Kozak

Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.

Pharmacology of Potassium Channels

Pharmacology of Potassium Channels
Author :
Publisher : Springer Nature
Total Pages : 546
Release :
ISBN-10 : 9783030840525
ISBN-13 : 3030840522
Rating : 4/5 (25 Downloads)

Synopsis Pharmacology of Potassium Channels by : Nikita Gamper

The aim of the present book is to comprehensively review current advances in understanding of genetics, structural biology, pharmacology of potassium channels and their roles in disease as well as to identify current gaps in knowledge. The ultimate goal is to provide a scientific foundation for better understanding of modulatory mechanisms and pharmacology of potassium channels and to use this understanding to drive future drug discovery. This book will be a must-have for academic and industrial scientists interested in physiology, pharmacology, pathology and structure-functional relationships of ion channels. The book will also be helpful for lecturers and students in the college and university classrooms, as well as for anyone interested in the state-of-the art in modern cell biology, physiology and pharmacology.