This textbook covers the most important aspects of what remains an actively changing area of knowledge. Topics include chirality, the determination of absolute configurations, stereochemical descriptors, chiroptic properties, asymmetric synthesis, and the resolution of racemates.

Unter Zirkulardichroismus (CD) versteht man die spezifisch unterschiedliche Absorption von links- und rechtszirkular polarisiertem Licht durch bestimmte Moleküle. CD-Effekte lassen sich in Abhängigkeit von der Wellenlänge messen und spektroskopisch auswerten; sie geben beispielsweise Auskunft über die Konformation organischer Verbindungen. Dieses Buch richtet sich an den organischen Chemiker, der mit den Grundprinzipien der Stereochemie vertraut ist, und erläutert die Anwendung der CD-Spektroskopie zur Konformationsanalyse ausführlich und verständlich. (06/00)

CHEMISTRY STUDENT GUIDES. GUIDED BY STUDENTS Why did the drug thalidomide cause birth defects? What is the chemical difference between sucrose and lactose in your food? Stereochemistry holds the answer and is essential to the understanding of the chemistry of life. Stereochemistry is an important concept that often causes confusion amongst students when they learn it for the first time. Unlike most other areas of chemistry, it requires the chemist to visualise molecules in 3D, which can be difficult. In this book we deal with tricky concepts like conformation and configuration, how to represent them accurately and how to use the correct terms to describe them in both organic and inorganic chemistry. We involved students in the writing process to ensure we deal with areas that you find difficult, in an understandable language. With problems designed to focus on common errors and misconceptions, real life examples, and practical hands-on exercises coupled with visualisation tips, our intention is to give you the tools to become confident in stererochemistry. Complementing mainstream organic textbooks, or self-study, this book is for anyone who has struggled with describing alkenes as E or Z, assigning R and S absolute configurations, drawing Newman projections or chair representations of cyclohexanes, axial chirality, understanding the stereochemistry of octahedral metal complexes and indeed explaining complexities observed in NMR spectra. Chemistry Student Guides are written with current students involved at every stage, guiding the books towards the most challenging aspects of the topic. Student co-authors for Introduction to Stereochemistry are Caroline Akamune, Michael Lloyd and Matthew Taylor.

This book discusses essential stereochemical concepts associated with organic molecules (natural or synthetic), as reflected in the course of their many reactions, their mechanisms, their asymmetric synthesis, biosynthesis, and biological activities. This treatise provides useful insights and understanding of the chiral/achiral designations (nomenclatures), the stereochemical features, and related properties of the natural and synthetic products. Without having an adequate knowledge of stereochemical concepts, it will not be possible to understand and appreciate the stereochemistry of natural or synthetic products. Thus, essential static and dynamic aspects of stereochemistry with sufficient illustrative examples along with discussions are presented. The structure of the monograph allows for easy selection of separate topics for reading and teaching. This book will also provide an idea of basic stereochemical concepts, as applied to organic molecules in general as well as to organic ligands in coordination complexes, and will, therefore, be valuable resources to teachers and students of advanced undergraduates and post-graduates, researchers, and professionals.

Stereochemistry of Organic Compounds The first fully referenced, comprehensive book on this subject in more than thirty years, Stereochemistry of Organic Compounds contains up-to-date coverage and insightful exposition of all important new concepts, developments, and tools in the rapidly advancing field of stereochemistry, including: * Asymmetric and diastereoselective synthesis * Conformational analysis * Properties of enantiomers and racemates * Separation and analysis of enantiomers and diastereoisomers * Developments in spectroscopy (including NMR), chromatography, and molecular mechanics as applied to stereochemistry * Prostereoisomerism * Conceptual foundations of stereochemistry, including terminology and symmetry concepts * Chiroptical properties Written by the leading authorities in the field, the text includes more than 4,000 references, 1,000 illustrations, and a glossary of stereochemical terms.

Conformal, diastereomers, rotamers, tautomers, anomers: The multitude of terms used in stereochemistry quickly makes this subfield of chemistry confusing. In addition, there are different nomenclatures and different forms of representation (Fischer projection, Haworth ring formula, Newman projection). This essential deals with basic static stereochemistry and gives an overview of the different isomeric forms and nomenclatures. It is thus both a help and a reference book. This Springer essential is a translation of the original German 1st edition essentials, Einführung in die Stereochemie by Torsten Schmiermund, published by Springer Fachmedien Wiesbaden GmbH, part of Springer Nature in 2019. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content, so that the book will read stylistically differently from a conventional translation. Springer Nature works continuously to further the development of tools for the production of books and on the related technologies to support the authors.

This book is an account for students of how the three-dimensional shapes of molecules influence their chemical and physical properties. It begins with the structures of molecules and then describes how such structures can be changed.

Stereochemistry has always occupied a central position and is pivotal to the practice of organic chemistry. A solid understanding of this subject is indeed critical to subsequent success in a science career. Stereochemistry is, therefore, a core constituent both at the undergraduate and postgraduate chemistry courses. This seventh edition is extensively revised and enlarged by adding new material to take account of recent developments and extensive amendments have been made to improve clarity. The key features of this new addition are: a brand new design. Incorporation of basic principles in boxes directly links the students to the main text;, and a large number of exercises with their solutions have been now added in each chapter. These exercises are set at appropriate places so that the students can test their command of a particular topic. New problems have been added at the end of each chapter. Chemical illustrations have been modified and developed for clarity and information. Generally the figures contain text as well, to decrease the need to refer back and forth to the text and for better understanding.

Conformational Analysis: Scope and Present Limitations contains the proceedings of the Brussels International Symposium on Conformational Analysis held in Brussels, Belgium, in September 1969. The papers focus on the theoretical aspects and applications of conformational analysis, such as those concerning the aliphatic and especially the cyclic series. Topics covered include the geometry of five-membered rings; conformational transmission in steroids; conformational aspects of N-quaternization; and applications of nuclear magnetic resonance spectrometry in conformational studies of cyclohexane derivatives. This book is comprised of 20 chapters and begins with a discussion on the conformational aspects of some five-membered ring compounds based mainly on observed (diffraction methods) and calculated torsional angles. The reader is then introduced to nuclear magnetic resonance studies of the conformations and conformational barriers in cyclic molecules; conformational studies of six-membered heterocycles; conformational transmission in steroids; and solvolytic cyclizations involving double bonds. The remaining chapters explore the conformational analysis of methylcyclohexane, cyclohexane systems, and carbonium ions; conformations of membrane-active cyclodepsipeptides; energetics of isomeric transition states and competitive reaction pathways in conformational analysis; and conformational aspects of the reaction of the 1-methylcyclodecane-l,6-diols with acid. This monograph will be of interest to organic chemists.