Preface to the Second Edition Since publication of the first edition, continuing developments in histopathology have motivated the inclusion of four new chapters: cytology, immunohistology, quality control and assessment, and the autopsy. The increasing use of cytology in clinical practice and advances in techniques and diagnostic interpretation justify the devotion of more space than formerly to this important topic. Immunohistology now merits a separate chapter because it has a status beyond that of being just another "special stain" and there are certain aspects of technique and interpretation that are peculiar to it. Quality control and assessment in histopathology are very topical and important now that greater attention is being paid to cost effectiveness and the auditing of many aspects of clinical practice. The autopsy is an integral part of the professional life of a histopathologist and, though it lacks the immediate clinical impact of the biopsy diagnosis, it nevertheless constitutes an important activity in all hospitals; without detailing dissection techniques I have provided some information and guidance about the autopsy which I believe will be useful to trainees and of interest to others. The remainder of the book has been thoroughly revised and updated, and illustrations and tables added where experience has shown that the text is insufficient. Sheffield, October 1986 J. C. E. Underwood Preface to the First Edition This book is primarily addressed to the needs of the trainee histopathologist.

This practical volume in the Biopsy Interpretation Series is your guide to effective diagnostic biopsy of the kidney and adrenal glands. Presented in a reader-friendly format, the text includes abundant photomicrographs of actual biopsy samples as well as correlative photos of surgical specimens and ancillary immunohistochemical studies. Each organ is addressed in a separate section that includes an introduction to biopsy techniques and an overview of normal histology. Positive diagnoses for renal lesions are described by tumor type. Adrenal lesions are grouped by primary and metastatic tumors, reflecting the main diagnostic considerations at the adrenal site. Uniquely detailed focus addresses the specific techniques and interpretive features of renal and adrenal biopsy. Timely content addresses the use of renal biopsy in minimally invasive therapeutic techniques as well as its role in active surveillance of renal masses. The latest ISUP classifications reflect newly described renal tumors discussed at the March 2012 USCAP annual meeting. Clinical implications of each diagnosis are highlighted throughout the text to guide therapeutic decision-making.

The Second Edition of Biopsy Interpretation: The Frozen Section, a volume in the Biopsy Interpretation Series, addresses the frozen section, which is one of several intraoperative consultative options. It illustrates the practical use of the frozen section in the management of clinical problems, especially tumors. The demands of patient care require knowledge of the assets and limitations of the frozen section, including the practical techniques of its execution, interpretation, and the communication of its results. Although the frozen section is the focus, the central idea behind this book is intraoperative consultation and patient management. This edition features updates to the organ system based chapters as well as a revised chapter on pediatric pathology. Two new chapters on hematopathology and a review of published literature have also been added. The goal of this book is to not only provide updated information on the practice of frozen section, but also to help explain the role the general surgical pathologist can play in the treatment of patients. Features: Histologic illustrations are actual frozen sections, with artifacts Updated and expanded text Emphasis is placed on the morphologic expertise of the surgical pathologist in standard hematoxylin and eosin sections and imprints

The volume of endoscopic biopsies being performed continues to grow rapidly and they now represent one of the most common specimens encountered in routine surgical pathology practice. It is essential to maintain the balance between the speed and accuracy while integrating emerging sophisticated pathology techniques into endoscopic biopsies in routine practice. Microscopic appearance is virtually diagnostic of certain diseases. In others a diagnosis may be rendered only after correlating the microscopic pattern with clinical clues aided by ancillary tests. This text provides a guide to systematic approach of endoscopic biopsies to render a safe, quick and accurate pathological diagnosis in an integrated manner as well as important information that pathologists and clinicians should know to get the best value of endoscopic biopsies. The first chapter introduces the key microscopic features that are normal and abnormal in the gut mucosa as appreciated in an endoscopic biopsy. The second chapter presents a general overview highlighting the neoplastic and non-neoplastic patterns that are common to the entire tubular gut. Because some patterns are common to many sites, an overarching chapter gives the reader a generalized approach, which will be further refined in subsequent site specific chapters. The disease etiologies of each pattern are discussed, with emphasis placed on the most common causes that will be encountered in clinical practice. The subsequent chapters that follow then concentrate on patterns encountered at specific anatomical locations. Under each anatomical location (esophagus, stomach, small intestine and large intestine) site specific patterns of both neoplastic and non-neoplastic conditions are described. Conditions that affect many sites in the gastrointestinal tract are discussed in detail in the most relevant site chapter, but are referred to in other chapters as the reaction pattern/s they produce at that site is discussed. Ancillary tests that are required for a diagnosis of some diseases in particular neoplastic conditions are listed with tips for interpretation. This is presented mostly in a table format to assist day-to-day quick reference. In keeping with recent advances of using small biopsies for testing clinically relevant bio markers, important information that the pathologists and clinicians need to know is highlighted in appropriate sites. Authored by experts in the field, each chapter is presented under headings that include diagnostic features, patterns with relevant endoscopic and clinical clues, traps and overlapping features, and appropriate ancillary tests including clinically relevant molecular signatures in endoscopic biopsies.

This new volume of the Biopsy Interpretation Series is a practical, superbly illustrated guide to the technical and interpretive aspects of a frozen section. The focus is on use of the frozen section in intraoperative management of patients, particularly those with tumors. The authors give pathologists a thorough knowledge of the utility and limitations of a frozen section, the appropriate circumstances for doing one, the proper techniques, and the interpretation and reporting of results. The book features more than 300 full-color gross and microscopic images, with discussions of differential diagnosis. A companion Website will provide 300 additional figures, plus a test bank that is ideal for board exam preparation.

Offering expert guidance on the practical use of the frozen section in the management of clinical problems, Biopsy Interpretation: The Frozen Section, 3rd Edition, is a highly illustrated, authoritative reference on this intraoperative consultative option. New editor Dr. Nicole A. Cipriani, along with Drs. Aliya N. Husain, Jerome B. Taxy, and a team of expert contributing authors, focus not only on how to view and interpret a slide, but also when to do a frozen section. Fully up to date with extensive new content and images, this third edition emphasizes intraoperative consultation and patient management, explaining the role the general surgical pathologist can play in the treatment of patients.

Diagnostic Pathology of the Intestinal Mucosa - An Atlas and Review of Biopsy Interpretation offers a comprehensive overview of intestinal mucosal structure as defined through peroral or endoscopic biopsy specimens obtained in normal and disease states. It describes small intestinal biopsy pathology in conjunction with morphologic, functional, and pathophysiologic correlations. Routine methods of processing tissues for light microscopy, electron microscopy, histochemistry, and light- and electron- microscopic-immunoperoxidase techniques are presented so that the novice in the area of intestinal structure may have an easily accessible reference for setting up a morphologic laboratory.

A practical guide for the diagnostic surgical pathologist, this new edition of Biopsy Interpretation of the Breast presents the diverse spectrum of pathologic alterations that occur in the breast in a manner analogous to that in which they are encountered in daily practice. Lesions are grouped together according to their histologic patterns rather than by the traditional benign-malignant categorization in order to simulate the way pathologists face these lesions as they examine microscopic slides on a daily basis. The role of adjunctive studies in solving diagnostic problems in breast pathology is emphasized where appropriate. In addition, the clinical significance and impact on patient management of the various diagnoses are discussed and key clinical and management points highlighted.