Insulin Like Growth Factors And Cancer
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Author |
: Derek LeRoith |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 290 |
Release |
: 2011-09-18 |
ISBN-10 |
: 9781461405986 |
ISBN-13 |
: 146140598X |
Rating |
: 4/5 (86 Downloads) |
Synopsis Insulin-like Growth Factors and Cancer by : Derek LeRoith
The book will detail the history, successes, and failures of targeted therapies for cancer, with a particular focus on IGF systems and cancer.
Author |
: Haim Werner |
Publisher |
: MDPI |
Total Pages |
: 196 |
Release |
: 2021-08-30 |
ISBN-10 |
: 9783036507705 |
ISBN-13 |
: 3036507701 |
Rating |
: 4/5 (05 Downloads) |
Synopsis Insulin-Like Growth Factors in Development, Cancers and Aging by : Haim Werner
This Special Issue of Cells on “Insulin-Like Growth Factors in Development, Cancers and Aging” provides a collection of modern articles dealing with the role of insulin-like growth factors (IGF1) in cancer biology, aging and development. Featured articles explore basic and clinical aspects of the IGF1 system, including post-genomic analyses as well as novel approaches to target the IGF1 receptor (IGF1R) in oncology.
Author |
: |
Publisher |
: Academic Press |
Total Pages |
: 766 |
Release |
: 2009-03-10 |
ISBN-10 |
: 9780080922157 |
ISBN-13 |
: 0080922155 |
Rating |
: 4/5 (57 Downloads) |
Synopsis Insulin and IGFs by :
First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.This volume focuses on insulin and IGFs. - Longest running series published by Academic Press - Contributions by leading international authorities
Author |
: Derek LeRoith |
Publisher |
: CRC Press |
Total Pages |
: 328 |
Release |
: 1991-05-28 |
ISBN-10 |
: 0849357128 |
ISBN-13 |
: 9780849357121 |
Rating |
: 4/5 (28 Downloads) |
Synopsis Insulin-like Growth Factors by : Derek LeRoith
During the past decade, the continued interest in insulin-related growth factors has been documented by a plethora of research programs and publications focused on these growth factors. Both molecular and cellular biological techniques have improved and enabled investigators to study the properties of the growth factors in depth. This volume covers the molecular (genetic) aspects of the growth factors, their binding proteins and receptors, as well as those factors affecting their gene transcription and translation. In addition, aspects of the cellular action of these growth factors through their receptors and how this impacts normal cellular function are discussed. The book will provide valuable information for researchers in physiology, biology, endocrinology, and metabolism.
Author |
: Robert C. Bast, Jr. |
Publisher |
: John Wiley & Sons |
Total Pages |
: 2004 |
Release |
: 2017-03-10 |
ISBN-10 |
: 9781119000846 |
ISBN-13 |
: 111900084X |
Rating |
: 4/5 (46 Downloads) |
Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.
Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Author |
: Derek LeRoith |
Publisher |
: |
Total Pages |
: 223 |
Release |
: 2003 |
ISBN-10 |
: OCLC:315121678 |
ISBN-13 |
: |
Rating |
: 4/5 (78 Downloads) |
Synopsis Insulin-like Growth Factors and Cancer by : Derek LeRoith
Author |
: Douglas Yee |
Publisher |
: IOS Press |
Total Pages |
: 134 |
Release |
: 2004 |
ISBN-10 |
: 158603409X |
ISBN-13 |
: 9781586034092 |
Rating |
: 4/5 (9X Downloads) |
Synopsis Insulin-Like Growth Factors by : Douglas Yee
Over the past five years there has been an explosion of "targeted therapies" for cancer treatment. In most cases, these therapies have been based on pre-clinical data showing that specific molecules play an important role in regulating the malignant phenotype. In breast cancer, there is compelling rationale that such targeted strategies should be successful. Targeting of estrogen receptor ? (ER?) has proven to be a successful way to reduce breast cancer risk, decrease the risk of death and recurrence in an adjuvant setting, and remains the first choice of treatment for advanced disease. With this success, it is hoped that other molecular pathways could also be successfully exploited. This publication reviews the role of the insulin-like growth factors (IGFs) in breast cancer. Over 100 years ago George Beatson made an intuitive leap connecting breast cancer therapy with ovarian function He removed the ovaries from a premenopausal woman with breast cancer; he reasoned that ovarian function regulated normal mammary gland function, therefore the ovaries may influence the malignant phenotype. Other discussion included cover the function of IGF action in the normal mammary gland using mouse model systems where expression and function can be manipulated and the patterns of expression of the IGFs, their binding proteins, and their receptors in the normal gland.
Author |
: Derek Leroith |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 524 |
Release |
: 2003-07-31 |
ISBN-10 |
: 0306478463 |
ISBN-13 |
: 9780306478468 |
Rating |
: 4/5 (63 Downloads) |
Synopsis Insulin-like Growth Factor Receptor Signalling by : Derek Leroith
Insulin-like growth factors are ubiquitously expressed and are crucial for growth and function of almost all cells. Together with their binding proteins and receptors, they form a widely studied biological system involving many proteins and characterized by complex interactions. In addition to its significance in growth and development, the insulin-like growth factor system also has important roles in a wide variety of pathological states. This has led to interest in the therapeutic potential of insulin-like growth factors and their binding proteins as candidate drug targets. This comprehensive book contains current information on both basic science and clinical aspects of IGFs and their regulatory proteins, with emphasis on their relevance to cancer.
Author |
: Kerry S. Courneya |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 389 |
Release |
: 2010-11-26 |
ISBN-10 |
: 9783642042317 |
ISBN-13 |
: 3642042317 |
Rating |
: 4/5 (17 Downloads) |
Synopsis Physical Activity and Cancer by : Kerry S. Courneya
This book explores in depth the relation between physical activity and cancer control, including primary prevention, coping with treatments, recovery after treatments, long-term survivorship, secondary prevention, and survival. The first part of the book presents the most recent research on the impact of physical activity in preventing a range of cancers. In the second part, the association between physical activity and cancer survivorship is addressed. The effects of physical activity on supportive care endpoints (e.g., quality of life, fatigue, physical functioning) and disease endpoints (e.g., biomarkers, recurrence, survival) are carefully analyzed. In addition, the determinants of physical activity in cancer survivors are discussed, and behavior change strategies for increasing physical activity in cancer survivors are appraised. The final part of the book is devoted to special topics, including the relation of physical activity to pediatric cancer survivorship and to palliative cancer care.
Author |
: Shashank Kumar |
Publisher |
: Springer Nature |
Total Pages |
: 363 |
Release |
: 2021-07-18 |
ISBN-10 |
: 9789811618468 |
ISBN-13 |
: 9811618461 |
Rating |
: 4/5 (68 Downloads) |
Synopsis Obesity and Cancer by : Shashank Kumar
This book highlights the concordance between signaling pathways that are involved in obesity and cancer cross-talks. It describes the role of cytokines, chemokines, growth factors, insulin, and adipokines in the development of obesity-associated cancers. The book reviews the role of inflammatory signaling pathways such as estrogen-mediated signaling, mTOR and AMP-activated protein kinase pathway and the involvement of adaptive and innate immunity, oxidative stress, gene polymorphism, dietary phytochemicals, and miRNAs in obesity and cancer. In addition, it covers the latest research on the drugs and natural therapeutic agents that target obesity-induced cancers and discusses various in vivo models for studying obesity and obesity-associated cancer. Lastly, it analyses the role of genetic polymorphisms in the obesity-related genes that influence cancer development. The book is a useful resource for researchers in the field of cancer, pharmacology, food chemistry, and clinical biochemistry.