Inositol Phospholipid Metabolism And Phosphatidyl Inositol Kinases
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Author |
: A. Kuksis |
Publisher |
: Elsevier |
Total Pages |
: 1002 |
Release |
: 2003-09-12 |
ISBN-10 |
: 9780444513212 |
ISBN-13 |
: 0444513213 |
Rating |
: 4/5 (12 Downloads) |
Synopsis Inositol Phospholipid Metabolism and Phosphatidyl Inositol Kinases by : A. Kuksis
Offers a review of developments along with tried and tested methods for isolation, resolution and quantification of inositol phospholipids and inositol polyphosphates in both cells and tissues. This book includes detailed methodology for identification of molecular species of inositol phospholipids, including their phosphates and glycans.
Author |
: Arnis Kuksis |
Publisher |
: |
Total Pages |
: 971 |
Release |
: 1969 |
ISBN-10 |
: LCCN:68054514 |
ISBN-13 |
: |
Rating |
: 4/5 (14 Downloads) |
Synopsis Inositol Phospholipid Metabolism and Phosphatidyl Inositol Kinases by : Arnis Kuksis
Author |
: Tamas Balla |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 361 |
Release |
: 2012-03-14 |
ISBN-10 |
: 9789400730113 |
ISBN-13 |
: 940073011X |
Rating |
: 4/5 (13 Downloads) |
Synopsis Phosphoinositides I: Enzymes of Synthesis and Degradation by : Tamas Balla
Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.
Author |
: Christopher J. Barker |
Publisher |
: Humana |
Total Pages |
: 260 |
Release |
: 2010-05-27 |
ISBN-10 |
: STANFORD:36105211747618 |
ISBN-13 |
: |
Rating |
: 4/5 (18 Downloads) |
Synopsis Inositol Phosphates and Lipids by : Christopher J. Barker
This text introduces the basic methodological tools to measure inositol lipids and phosphates and also describes new approaches that have become available in the last ten years, including g RNA-silencing and the protocols involving inositol pyrophosphates.
Author |
: S.K. Sopory |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 328 |
Release |
: 2012-12-06 |
ISBN-10 |
: 9781461513650 |
ISBN-13 |
: 1461513650 |
Rating |
: 4/5 (50 Downloads) |
Synopsis Signal Transduction in Plants by : S.K. Sopory
An understanding of the mechanisms by which plants perceive environmental cues, both physical and chemical, and transduce the signals that influence specific expression of genes, is an area of intensive scientific research. With the completion of the genome sequence of Arabidopsis it is understood now that a larger number of genes encode for proteins involved in signalling cascades and transcription factors. In this volume, different chapters deal with plant receptors, second messengers like calcium ions, phosphoinositides, salicylic acid and nitrous oxide, calcium binding proteins and kinases. In addition to dealing with the response of plants to light, hormones, pathogens, heat, etc. on cellular activity, work currently going on in apoptosis, cell division, and plastid gene expression is also covered in this book.
Author |
: Neale Ridgway |
Publisher |
: Elsevier |
Total Pages |
: 625 |
Release |
: 2015-07-24 |
ISBN-10 |
: 9780444634498 |
ISBN-13 |
: 0444634495 |
Rating |
: 4/5 (98 Downloads) |
Synopsis Biochemistry of Lipids, Lipoproteins and Membranes by : Neale Ridgway
Biochemistry of Lipids: Lipoproteins and Membranes, Volume Six, contains concise chapters that cover a wide spectrum of topics in the field of lipid biochemistry and cell biology. It provides an important bridge between broad-based biochemistry textbooks and more technical research publications, offering cohesive, foundational information. It is a valuable tool for advanced graduate students and researchers who are interested in exploring lipid biology in more detail, and includes overviews of lipid biology in both prokaryotes and eukaryotes, while also providing fundamental background on the subsequent descriptions of fatty acid synthesis, desaturation and elongation, and the pathways that lead the synthesis of complex phospholipids, sphingolipids, and their structural variants. Also covered are sections on how bioactive lipids are involved in cell signaling with an emphasis on disease implications and pathological consequences. - Serves as a general reference book for scientists studying lipids, lipoproteins and membranes and as an advanced and up-to-date textbook for teachers and students who are familiar with the basic concepts of lipid biochemistry - References from current literature will be included in each chapter to facilitate more in-depth study - Key concepts are supported by figures and models to improve reader understanding - Chapters provide historical perspective and current analysis of each topic
Author |
: B.B. Biswas |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 433 |
Release |
: 2013-11-11 |
ISBN-10 |
: 9781461303435 |
ISBN-13 |
: 1461303435 |
Rating |
: 4/5 (35 Downloads) |
Synopsis myo-Inositol Phosphates, Phosphoinositides, and Signal Transduction by : B.B. Biswas
`The heterogeneity of topics ... is very ambitious, and the result is, overall, successful because of the high quality of the individual contributions ... highly recommended.' -American Scientist, from a review of a previous volume Volume 26 examines the emerging areas of signal transduction based on myoinositol phosphates and Ca2+ while focusing on plant and animal responses. Chapters explore synthesis, separation, and identification of different inositol phosphates.
Author |
: Jacques Fantini |
Publisher |
: Academic Press |
Total Pages |
: 398 |
Release |
: 2015-05-12 |
ISBN-10 |
: 9780128004920 |
ISBN-13 |
: 0128004924 |
Rating |
: 4/5 (20 Downloads) |
Synopsis Brain Lipids in Synaptic Function and Neurological Disease by : Jacques Fantini
Lipids are the most abundant organic compounds found in the brain, accounting for up to 50% of its dry weight. The brain lipidome includes several thousands of distinct biochemical structures whose expression may greatly vary according to age, gender, brain region, cell type, as well as subcellular localization. In synaptic membranes, brain lipids specifically interact with neurotransmitter receptors and control their activity. Moreover, brain lipids play a key role in the generation and neurotoxicity of amyloidogenic proteins involved in the pathophysiology of neurological diseases. The aim of this book is to provide for the first time a comprehensive overview of brain lipid structures, and to explain the roles of these lipids in synaptic function, and in neurodegenerative diseases, including Alzheimer's, Creutzfeldt-Jakob's and Parkinson's. To conclude the book, the authors present new ideas that can drive innovative therapeutic strategies based on the knowledge of the role of lipids in brain disorders. - Written to provide a "hands-on" approach for readers - Biochemical structures explained with molecular models, and molecular mechanisms explained with simple drawings - Step-by-step guide to memorize and draw lipid structures - Each chapter features a content summary, up-to-date references for additional study, and a key experiment with an explanation of the technique
Author |
: Tamas Balla |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 467 |
Release |
: 2012-02-28 |
ISBN-10 |
: 9789400730151 |
ISBN-13 |
: 9400730152 |
Rating |
: 4/5 (51 Downloads) |
Synopsis Phosphoinositides II: The Diverse Biological Functions by : Tamas Balla
Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume II extends into the role of phosphoinositides in membrane organization and vesicular traffic. Endocytosis and exocytosis are modulated by phosphoinositides, which determine the fate and activity of integral membrane proteins. Phosphatidylinositol(4,5)-bisphosphate is a prominent flag in the plasma membrane, while phosphatidylinositol-3-phosphate decorates early endosomes. The Golgi apparatus is rich in phosphatidylinositol-4-phosphate, stressed cells increase phosphatidylinositol(3,5)-bisphosphate, and the nucleus has a phosphoinositide metabolism of its own. Phosphoinositide-dependent signaling cascades and the spatial organization of distinct phosphoinositide species are required in organelle function, fission and fusion, membrane channel regulation, cytoskeletal rearrangements, adhesion processes, and thus orchestrate complex cellular responses including growth, proliferation, differentiation, cell motility, and cell polarization.
Author |
: R. H. Michell |
Publisher |
: Cold Spring Harbor Laboratory Press |
Total Pages |
: 184 |
Release |
: 1987 |
ISBN-10 |
: UCAL:B5041078 |
ISBN-13 |
: |
Rating |
: 4/5 (78 Downloads) |
Synopsis Inositol Lipids in Cellular Signaling by : R. H. Michell