Demonstrating that the magnitude and pattern of cardiovascular response to stress varies markedly between individuals, this work discusses the mechanisms by which the cardiovascular system is mobilized during stress, the determinants of individual differences, and the pathophysiological processes by which responses to stress may lead to cardiovascular disease. Behavioral scientists from a variety of disciplines will find the work pertinent to their research.

It was my original intention to write a reasonably advanced psycho physiology text that would go beyond cardiovascular activity. This I believed would require a collaborative effort since my expertise outside of cardiovascular psychophysiology is too limited. After some initial limited efforts to organize such a venture, it became apparent that a text of this nature was not feasible. Thus, the effort was dropped. I did, however, receive encouragement to write the present monograph, which is more a personalized document than a text. As will become apparent, this monograph relies heavily on research from my laboratory and details the manner in which our conceptualizations of the issues have developed. At first, I believed such an effort premature since such a personalized document was something one composes upon retire ment. However, I was persuaded by some individuals (who shall re main anonymous, just in case they end up regretting their actions) to undertake the present effort. There are several people, who have rendered assistance in the preparation of this monograph, for whose efforts I am extremely grate ful. Extensive editorial assistance and encouragement were provided by Kathleen C. Light and Alberto Grignolo. Also assisting editorially were Ellen Z. Curtin, Allison Cahill, and Carolyn Williams. I wish also to thank my long-time secretary, Virginia Hodson, and Jenny Adams, for their typing assistance. There are six people to whom I would like to dedicate this book.

Leading the way in this field, the Encyclopedia of Quantitative Risk Analysis and Assessment is the first publication to offer a modern, comprehensive and in-depth resource to the huge variety of disciplines involved. A truly international work, its coverage ranges across risk issues pertinent to life scientists, engineers, policy makers, healthcare professionals, the finance industry, the military and practising statisticians. Drawing on the expertise of world-renowned authors and editors in this field this title provides up-to-date material on drug safety, investment theory, public policy applications, transportation safety, public perception of risk, epidemiological risk, national defence and security, critical infrastructure, and program management. This major publication is easily accessible for all those involved in the field of risk assessment and analysis. For ease-of-use it is available in print and online.

Pituitary Adenylate Cyclase-Activating Polypeptide is the first volume to be written on the neuropeptide PACAP. It covers all domains of PACAP from molecular and cellular aspects to physiological activities and promises for new therapeutic strategies. Pituitary Adenylate Cyclase-Activating Polypeptide is the twentieth volume published in the Endocrine Updates book series under the Series Editorship of Shlomo Melmed, MD.

Cardiovascular disease continues to be the number ioral medicine" was developed and shaped into the one source of morbidity and mortality in our coun­ following definition: try. Despite a 35% reduction since 1964, these Behavioral medicine is the interdisciplinary field con­ diseases, particularly coronary heart disease cerned with the development and integration of behav­ (CHD), claim nearly 1,000,000 lives each year in ioral and biomedical science knowledge and techniques the United States (Havlik & Feinleib, 1979). relevant to the understanding of health and illness and The Framingham study, among others, has iden­ the application of this knowledge and these techniques to prevention, diagnosis, treatment and rehabilitation. tified three major risk factors implicated in the de­ (Schwartz & Weiss, 1978) velopment of CHD: smoking, elevated serum cho­ lesterol, and high blood pressure (Castelli et at., This concept of "biobehavioral" collaboration 1986). Given that these factors account for less challenged scientists and clinicians of many disci­ than 50% of the variance associated with CHD plines to consider how they might more effectively (Jenkins, 1976), it has become obvious that addi­ develop diagnostic, treatment, and prevention tional risk factors must be identified if further pro­ strategies by merging their perspectives to address gress is to be made in disease prevention and simultaneously, among others, behavioral, psy­ control.

As the population of older Americans grows, it is becoming more racially and ethnically diverse. Differences in health by racial and ethnic status could be increasingly consequential for health policy and programs. Such differences are not simply a matter of education or ability to pay for health care. For instance, Asian Americans and Hispanics appear to be in better health, on a number of indicators, than White Americans, despite, on average, lower socioeconomic status. The reasons are complex, including possible roles for such factors as selective migration, risk behaviors, exposure to various stressors, patient attitudes, and geographic variation in health care. This volume, produced by a multidisciplinary panel, considers such possible explanations for racial and ethnic health differentials within an integrated framework. It provides a concise summary of available research and lays out a research agenda to address the many uncertainties in current knowledge. It recommends, for instance, looking at health differentials across the life course and deciphering the links between factors presumably producing differentials and biopsychosocial mechanisms that lead to impaired health.

Stress and Health: Biological and Psychological Interactions is a brief and accessible examination of psychological stress and its psychophysiological relationships with cognition, emotions, brain functions, and the peripheral mechanisms by which the body is regulated. Updated throughout, the Third Edition covers two new and significant areas of emerging research: how our early life experiences alter key stress responsive systems at the level of gene expression; and what large, normal, and small stress responses may mean for our overall health and well-being.

The main aim of this book is to evaluate the concept of stress and provide tools for physicians to identify patients who might benefit from stress management. This will incorporate a detailed description of the physiological and pathophysiological consequences of acute and chronic stress that might lead to cardiovascular disease. The book will aim to critically evaluate interventional research (behavioural and other therapies) and provide evidence based recommendations on how to manage stress in the cardiovascular patient. Our intentions are to define and highlight stress as an etiological factor for cardiovascular disease, and to describe an evidence based "tool box" that physicians may use to identify and manage patients in whom stress may be an important contributing factor for their disease and their risk of suffering cardiovascular complications.

The third edition of this popular and successful text has been fully revised and updated to take account of recent advances in the field, particularly in the physiology and pathophysiology of many disease processes. The text retains the original format of relevant physiology, test selection and test interpretation by case example. Essential aspects of paediatric chemical pathology, inborn errors of metabolism, reproductive endocrinology, tumours and toxicology are now included. As chemical pathology is receiving specific attention in medical courses, this text has been adapted to present this information in an understandable form, making it suitable for medical undergraduates and for medical and science postgraduates studying for exams of Colleges of Pathology and professional associations."

This book is an articulate, concise, contemporary introduction to the study of important variables underlying cardiovascular reactivity. Its strength is in the combination of a scholarly but nonpedantic approach to cardiovascular psychophysiology and a solid understanding of be havioral medicine approaches to the study of hypertension. The topics covered are central to the study of relationships between behavior and cardiovascular reactivity; the list of suggested readings at the end of each chapter provides excellent guidance for more detailed study of specific issues. It has now been more than a dozen years since Plenum Press published Paul Obrist's seminal monograph Cardiovascular Psycho physiology. The volume had a major impact in relating cardiovascular regulation to behaving individuals and in developing thoughtful hy potheses concerning such factors as they might pertain to hypertension. The impact of that work extended across scientific disciplines as well as aross continents. At the time the Obrist book was published, a young psychologist, J. Rick Turner, was completing his Ph. D. thesis in psychol ogy at the University of Birmingham, England, on heart rate reactions to psychological challenge. After continued collaboration for the next several years with his former Ph. D. mentor, Douglas Carroll, Turner joined the Obrist laboratory at the University of North Carolina. Al though Obrist unfortunately died during Turner's tenure in the labora tory, collaboration continued with Kathleen Light and Andrew Sher wood. The enlightened legacy of the North Carolina laboratory can clearly be seen in this text.