Principles and Practice of Skin Toxicology

Principles and Practice of Skin Toxicology
Author :
Publisher : John Wiley & Sons
Total Pages : 392
Release :
ISBN-10 : 9780470773086
ISBN-13 : 0470773081
Rating : 4/5 (86 Downloads)

Synopsis Principles and Practice of Skin Toxicology by : Robert Chilcott

Written by authorities in the field, this book provides a “bottom up” approach to studying skin toxicology. Principles and Practice of Skin Toxicology clearly outlines basic concepts, cites historical and modern references and contains a dictionary for easy reference. The inclusion of global legislation and regulatory aspects on the topic makes this a comprehensive review for every practitioner, clinical researcher in industry and academia, and MSc and PhD student of toxicology. Different sections cover skin structure and function, principles and measurement of skin absorption, clinical aspects of dermal toxicity and in vitro alternatives. A section on regulatory and legislative aspects includes case studies from the UK that fulfill European Union and US FDA requirements. A glossary provides definitions of technical terms, and the chapters contain an introduction, learning boxes and summary section for ease of use. Includes a chapter on drug delivery through the skin. Addresses risk assessment: a key area for the interpretation of skin absorption data that is rarely covered.

OECD Guidelines for Testing of Chemicals

OECD Guidelines for Testing of Chemicals
Author :
Publisher : Organisation for Economic Co-operation and Development ; [Montréal : Renouf]
Total Pages :
Release :
ISBN-10 : 9264122214
ISBN-13 : 9789264122215
Rating : 4/5 (14 Downloads)

Synopsis OECD Guidelines for Testing of Chemicals by : Organisation for Economic Co-operation and Development

In Vitro Skin Toxicology

In Vitro Skin Toxicology
Author :
Publisher : Mary Ann Liebert
Total Pages : 498
Release :
ISBN-10 : UOM:39015034910342
ISBN-13 :
Rating : 4/5 (42 Downloads)

Synopsis In Vitro Skin Toxicology by : Andre Rougier

In Vitro Toxicology Systems

In Vitro Toxicology Systems
Author :
Publisher : Humana
Total Pages : 0
Release :
ISBN-10 : 1493954806
ISBN-13 : 9781493954803
Rating : 4/5 (06 Downloads)

Synopsis In Vitro Toxicology Systems by : Anna Bal-Price

In Vitro Toxicology Systems brings together important issues and considerations needed in order to develop a workable, reliable, integrated testing strategy for the replacement of animals in toxicity testing regimes. This thorough volume includes sections on in vitro models for systemic organ toxicity, neurotoxicity, sensory organs, immunotoxicity and reproductive toxicity and addresses how stem cells may be used going forward. The book also tackles difficult areas of toxicology such as carcinogenicity and nanotoxicology, with additional chapters dedicated to kinetics, metabolism, and in vitro in vivo extrapolation. The book also addresses biological processes such as stress response pathways and mechanistic biomarkers and how these can be uncovered and measured using high content approaches. Reliable and authoritative, In Vitro Toxicology Systems will be of benefit not only to students, scientists and regulators working in the field of chemical safety assessment but also to a wider scientific audience.

Toxicology of the Skin

Toxicology of the Skin
Author :
Publisher : CRC Press
Total Pages : 452
Release :
ISBN-10 : 9781420079180
ISBN-13 : 1420079182
Rating : 4/5 (80 Downloads)

Synopsis Toxicology of the Skin by : Nancy A. Monteiro-Riviere

This key volume of the Target Organ Toxicology Series provides a fresh and modern approach to the subject of skin toxicology from the perspective of how the skin forms a barrier that protects the body from the external environment and how chemicals and drugs interact with the barrier properties of the skin. Any defects or perturbations to this barr

Toxicity Testing in the 21st Century

Toxicity Testing in the 21st Century
Author :
Publisher : National Academies Press
Total Pages : 217
Release :
ISBN-10 : 9780309109925
ISBN-13 : 0309109922
Rating : 4/5 (25 Downloads)

Synopsis Toxicity Testing in the 21st Century by : National Research Council

Advances in molecular biology and toxicology are paving the way for major improvements in the evaluation of the hazards posed by the large number of chemicals found at low levels in the environment. The National Research Council was asked by the U.S. Environmental Protection Agency to review the state of the science and create a far-reaching vision for the future of toxicity testing. The book finds that developing, improving, and validating new laboratory tools based on recent scientific advances could significantly improve our ability to understand the hazards and risks posed by chemicals. This new knowledge would lead to much more informed environmental regulations and dramatically reduce the need for animal testing because the new tests would be based on human cells and cell components. Substantial scientific efforts and resources will be required to leverage these new technologies to realize the vision, but the result will be a more efficient, informative and less costly system for assessing the hazards posed by industrial chemicals and pesticides.

Dermal Absorption and Toxicity Assessment

Dermal Absorption and Toxicity Assessment
Author :
Publisher : CRC Press
Total Pages : 704
Release :
ISBN-10 : 9780849375927
ISBN-13 : 0849375924
Rating : 4/5 (27 Downloads)

Synopsis Dermal Absorption and Toxicity Assessment by : Michael S. Roberts

The source Dermal Absorption and Toxicity Assessment supplies a state-of-the-art overview of the dermal absorption process, and is divided into six well organized sections. Written by internationally recognized experts in the field, this Second Edition is a complete revised and updated text, covering the wide range of methods used to assess skin ab

In Vitro Toxicology

In Vitro Toxicology
Author :
Publisher : Academic Press
Total Pages : 250
Release :
ISBN-10 : 9780128047712
ISBN-13 : 0128047712
Rating : 4/5 (12 Downloads)

Synopsis In Vitro Toxicology by : Alok Dhawan

In Vitro Toxicology details the protocols and methods of in vitro testing, highlighting the usefulness of models, methods and the cost-effectiveness and reproducibility of such methodologies. The current approaches and strategies required to develop an easy, reliable, validated and high throughput system for use in alternative animal models to circumvent in vivo testing are discussed in detail. The book also includes chapters on the principles involved in the general selection and use of models that address safety concerns, regulatory acceptance and the current understandings and strategies for the identification of biomarkers in toxicity testing. Furthermore, principles involved in the general selection and use of models that address the issues of safety concerns and regulatory acceptance of these models are discussed, making the book beneficial to students, scientists, and regulators working in toxicology, as well as those in the field of chemicals and the safety assessment of novel materials. - Discusses new techniques and protocols in a clear and concise manner - includes examinations of nanotoxicity, genotoxicity and carcinogenicity - Explains practical laboratory methods and the theories behind in vitro testing

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 428: Skin Absorption: In Vitro Method

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 428: Skin Absorption: In Vitro Method
Author :
Publisher : OECD Publishing
Total Pages : 8
Release :
ISBN-10 : 9789264071087
ISBN-13 : 9264071083
Rating : 4/5 (87 Downloads)

Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 428: Skin Absorption: In Vitro Method by : OECD

This Test method has been designed to provide information on absorption of a test substance, (ideally radiolabelled), applied to the surface of a skin sample separating the two chambers (a donor chamber and a receptor chamber) of a diffusion cell ...

In Vitro Toxicology, Second Edition

In Vitro Toxicology, Second Edition
Author :
Publisher : CRC Press
Total Pages : 419
Release :
ISBN-10 : 9781560327691
ISBN-13 : 1560327693
Rating : 4/5 (91 Downloads)

Synopsis In Vitro Toxicology, Second Edition by : Shayne C. Gad

Toxicology has made tremendous strides in the sophistication of the models used to identify and understand the mechanisms of agents that can harm or kill humand and other higher organisms. Non-animals or in vitro models started to gain significant use in the 1960s. As a result of the increased concern over animal welfare, economic factors, and the need for greater sensitivity and understanding of mechanisms, interest in in vitro^n models has risen. This volume demonstrates that there now exists a broad range of in vitro models for use in either identifying or understanding most forms of toxicity. The availability of in vitro models spans both the full range of endpoints (irritation, sensitization, lethality, mutagenicity, and devlopmental toxicity) and the full spectrum of target organ systems (skin, eye, heart, liver, kidney, nervous system, etc.). Chapters are devoted to each of these speciality areas from a perspective of presenting the principal models and their uses and limitations. Chapters that overview the principles involved in the general selection and use of models, and that address the issues of safety concerns and regulatory acceptance of these methods are also included.