**A Sunday Times and New York Times bestseller** Out now: The bestselling book from the creator of the wildly popular science YouTube channel, Kurzgesagt - In a Nutshell, a gorgeously illustrated deep dive into the immune system that will change how you think about your body forever. Please note: the originally supplied fixed format edition of the eBook has now been replaced to address difficulties experienced by some readers. Please delete the previous version from your device and download the new edition. __________ 'A truly brilliant introduction to the human body's vast system for fighting infections and other threats' JOHN GREEN, #1 New York Times bestselling author of The Fault in Our Stars 'Reads as if it's a riveting sci-fi novel . . . a delightful treat for the curious' TIM URBAN, creator of Wait But Why __________ You wake up and feel a tickle in your throat. Your head hurts. You're mildly annoyed as you get the kids ready for school and dress for work yourself. Meanwhile, an utterly epic war is being fought, just below your skin. Millions are fighting and dying for you to be able to complain as you drink your cup of tea and head out the door. So what, exactly, IS your immune system? Second only to the human brain in its complexity, it is one of the oldest and most critical facets of life on Earth. Without it, you would die within days. In Immune, Philipp Dettmer, the brains behind the most popular science channel on YouTube, takes readers on a journey through the fortress of the human body and its defences. There is a constant battle of staggering scale raging within us, full of stories of invasion, strategy, defeat, and noble self-sacrifice. In fact, in the time you've been reading this, your immune system has probably identified and eradicated a cancer cell that started to grow in your body. Each chapter delves deeply into an element of the immune system, including defences like antibodies and inflammation as well as threats like viruses, bacteria, allergies and cancer, as Dettmer reveals why boosting your immune system is actually nonsense, how parasites sneak their way past your body's defences, how viruses - including the coronavirus - work, and what goes on in your wounds when you cut yourself. Enlivened by engaging full-colour graphics and immersive descriptions, Immune turns one of the most intricate, interconnected, and confusing subjects - immunology - into a gripping adventure through an astonishing alien landscape. Challenging what you know and think about your own body and how it defends you against all sorts of maladies and how it might also eventually be your own downfall, Immune is a vital and remarkably fun crash course in what is arguably, and increasingly, the most important system in the body. __________

The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Immune Rebalancing: The Future of Immunosuppression summarizes the most promising perspectives of immunopharmacology, in particular in the area of immunosuppression by considering molecular pathways, personalized medicine, microbiome and nanomedicine. Modulation of immune responses for therapeutic purposes is a particularly relevant area, given the central role of anomalous immunity in diseases. These diseases vary from the most typically immune-related syndromes (autoimmune diseases, allergy and asthma, immunodeficiencies) to those in which altered immunity and inflammation define the pathological outcomes (chronic infections, tumours, chronic inflammatory and degenerative diseases, metabolic disorders, etc. - Visits immunosuppression from a modern point of view of signalling mechanisms at the light of the current knowledge of signalling mechanisms and regulatory networks allows the reader to formulate new ideas and concepts on how to use immunosuppression the therapeutic purposes - Encourages researchers to engage into exploring the field of pharmacological modulation of immune responses in depth, and with the new knowledge and tools available, designs more effective therapeutic strategies to autoimmune and inflammatory diseases, cancer, degenerative diseases and infections - Examines the link between molecular pathways associated to immune-suppression and the new immunopharmacology approaches - Provides information on the new strategies for drug development in this field - Considers the role of microbes in the development of the mammalian immune system and immune responses, which will widen the reader's strategy for addressing therapeutic immune modulations

Stiehm’s Immune Deficiencies: Inborn Errors in Immunity, Second Edition, is ideal for physicians and other caregivers who specialize in immunology, allergies, infectious diseases and pulmonary medicine. It provides a validated source of information for care delivery to patients, covering approaches to diagnosis that use both new genetic information and emphasize screening strategies. Management has changed dramatically over the past five years, so approaches to infection and autoimmunity are emphasized in an effort to improve outcomes and disseminate new information on the uses of targeted therapy. Covers immune deficiencies that are presented in a practical way, providing helpful information for active clinicians Fills an increasingly deep gap in the information available to clinicians Presents both clinical management and scientific advances for immune deficiencies Provides a primary resource for physicians in the field of immunodeficiencies Includes website access to a range of videos relevant to the topics discussed

The Immune Response is a unique reference work covering the basic and clinical principles of immunology in a modern and comprehensive fashion. Written in an engaging conversational style, the book conveys the broad scope and fascinating appeal of immunology. The book is beautifully illustrated with superb figures as well as many full color plates. This extraordinary work will be an invaluable resource for lecturers and graduate students in immunology, as well as a vital reference for research scientists and clinicians studying related areas in the life and medical sciences. - Current and thorough 30 chapter reference reviewed by luminaries in the field - Unique 'single voice' ensures consistency of definitions and concepts - Comprehensive and elegant illustrations bring key concepts to life - Provides historical context to allow fuller understanding of key issues - Introductory chapters 1-4 serve as an 'Immunology Primer' before topics are discussed in more detail

A thrilling, fact-packed journey of discovery through the body's immune system The human body is like an exceedingly well-fortified castle, defended by billions of soldiers – some live for less than a day, others remember battles for decades, but all are essential in protecting us from disease. This hidden army is our immune system, and without it we could not survive the eternal war between our microscopic enemies and ourselves. Immune explores the incredible arsenal that lives within us – how it knows what to attack and what to defend, and how it kills everything from the common cold virus to plague bacteria. We see what happens when the immune system turns on us, and how life is impossible without its protection. We learn how diseases try to evade the immune system and exploit its vulnerabilities, and we discover how scientists are designing new drugs to harness the power of the system to fight disease. Do transplants ever reject their new bodies? What is pus? How can your body make more antibodies than there are stars in our galaxy? Why is cancer so hard for our immune system to fight? Why do flu outbreaks cause a spike in sleep disorders? Can we smell someone else's immune system, and does that help us subconsciously decide who we fall in love with? In this book, Catherine Carver answers all of these compelling questions, and many more besides. Drawing on everything from ancient Egyptian medical texts to cutting-edge medical science, Immune will take you on an adventure packed with weird and wonderful revelations about your own internal defensive system.

Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation: Models in Discovery and Translation, Second Edition once again provides clinical and scientific researchers with a deep understanding of the current research in this field and the implications for translational practice. By providing an overview of the immune biology of HSCT, an explanation of immune rejection, and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex processes involved. It then moves on to discuss the immunobiology mechanisms that influence graft-versus-host disease (GVHD), graft-versus-leukemia effect, and transplantation success. Using illustrative figures, highlighting key issues, describing recent successes, and discussing unanswered questions, this book sums up the current state of HSCT to enhance the prospects for the future. The second edition is fully revised and includes new chapters on microbiome, metabolism, kinase targets, micro-RNA and mRNA regulatory mechanisms, signaling pathways in GVHD, innate lymphoid system development, recovery and function in GVHD, genetically engineered T-cell therapies, immune system engagers for GVHD and graft-versus-tumor, and hematopoietic cell transplant for tolerance induction in solid organ grafts. - Brings together perspectives from leading laboratories and clinical research groups to highlight advances from bench to the bedside - Guides readers through the caveats that must be considered when drawing conclusions from studies with animal models before correlating to clinical allogeneic hematopoietic stem cell transplantation (HSCT) scenarios - Categorizes the published advances in various aspects of immune biology of allogeneic HSCT to illustrate opportunities for clinical applications

This text emphasizes the human immune system and presents concepts with a balanced level of detail to describe how the immune system works. Written for undergraduate, medical, veterinary, dental, and pharmacy students, it makes generous use of medical examples to illustrate points. This classroom-proven textbook offers clear writing, full-color illustrations, and section and chapter summaries that make the content accessible and easily understandable to students.

The Evolution of the Immune System: Conservation and Diversification is the first book of its kind that prompts a new perspective when describing and considering the evolution of the immune system. Its unique approach summarizes, updates, and provides new insights on the different immune receptors, soluble factors, and immune cell effectors. - Helps the reader gain a modern idea of the evolution of the immune systems in pluricellular organisms - Provides a complete overview of the most studied and hot topics in comparative and evolutionary immunology - Reflects the organisation of the immune system (cell-based, humoral [innate], humoral [adaptive]) without introducing further and misleading levels of organization - Brings concepts and ideas on the evolution of the immune system to a wide readership