The book covers up-to-date information on nucleosides and antiviral chemotherapy contributed by the world experts in the field of nucleoside. This book is the result of a meeting honoring Dr. Jack J. Fox, who was one of the pioneers in nucleoside chemistry and chemotherapy. This book consists of 15 excellent chapters in the area, which include topics from recent synthetic methodologies, nucleoside kinase implicated in chemotherapy and drug design, excellent reviews on antiviral agents, nucleoside metabolism/mode of action in parasites, new compounds under clinical and pre-clinical trials, IMPDH inhibitors to review on nucleoside prodrugs.

Significant Pharmaceuticals Reported in US Patents identifies the next generation of pharmaceuticals reported in US Patents. This "hands-on" title provides explicit laboratory methods for preparing the most recent and effective medications. Each entry documents the biological testing protocols used to evaluate a drug and the significance of the current treatment agent over previous methods. Pharmaceuticals are included in this review only if at least two of the following criteria were met: Effectiveness in treating an illness, Innovative, ease of preparation, synergy with existing Medications. Pharmaceuticals are reported for 27 separate classes of illness, including: AIDS, Alzheimer's Disease, Cardiovascular Disorders, Diabetes, Epilepsy, Hepatitis C, Osteoporosis, Obesity and Sleep Disorders. Significant Pharmaceuticals Reported in US Patents has been designed to be used as both a reference and synthetic guide for pharmaceutical, medicinal and organic chemists and graduate students. Researchers working in other areas will also find the information valuable as in many instances intermediates or the next generation pharmaceutical are readily convertible into other industrial products including: anti-oxidants, chemical additives, herbicides, polymer precursors, water purification agents. Clear structural depictions of reagents and chemical transformations have been supplied to permit the identification of other future applications. Identifies next generation pharmaceuticals Provides practical preparation methods for each active agent and derivatives Documents the analytical characterization and biological testing results of active agents

This publication contains the Review Lectures given at a joint NATO Advanced Study Institute and a FEB S Advanced Study Course, held at Sogesta (Nr. Urbino), Italy from the 7th - 18th May 1979. The Course entitled "Nucleoside Analogues : Chemistry, Biology and Medical Applications" was held for several reasons. In the past few years, many useful and potentially-useful nucleoside analogues have either reached the stage of clinical use or are undergoing clinical trials. Many more compounds have been synthesised by the organic chemist and little more has been done with them other than possibly a few perfunctory biological tests. This is often due to either a lack of interest or an inadequate knowledge of the testing proced ures available or a lack of communication between the chemist, biochemist, pharmacologist and the clinician such that few compounds receive the testing and evaluation which they deserve. The aim of this meeting was to gather together many of the experts in the different scientific disciplines which are involved in the design, synthesis, testing and clinical use of nucleoside analogues, primarily as anti-viral and anti-cancer agents, and to discuss in depth the fundamental principles of each discipline so that participants could understand each other's problems and be more aware of the information required and that which can be obtained.

Indexing terms used in CRISP (Computer Retrieval of Information on Scientific Projects) and in Research grants index. Alphabetical arrangement. Cross references under terms.

Chemistry and Biology of Nucleosides and Nucleotides is a collection of papers presented at the symposium on the Chemistry and Biology of Nucleosides and Nucleotides, held on August 30-September 1, 1976, as part of the San Francisco Centennial Meeting of the Carbohydrate Division of the American Chemical Society. Contributors explore the chemistry and biology of nucleosides and nucleotides ans well as the different chemical and instrumental techniques used in their synthesis. This book is comprised of 28 chapters and begins by describing the synthesis of a gene and its introduction into a biological system where it proved to be functional. The synthesis of nucleosides and nucleotides with anticancer and antiviral activity is also discussed, along with the rationale for the design and synthesis of such compounds. Simple models of nucleic acid interactions are described. Subsequent chapters explore the chemistry and biological activity of C-nucleosides related to pseudouridine and of some nucleoside analogs active against tumor cells; the selectivity and stereospecificity of the ribosylation reaction; synthesis of C-glycosyl thiazoles; and C-nucleoside isosteres of some nucleoside antibiotics. This monograph will serve as reference and source material for many workers in biomedical research as teaching material for instructors of advanced science courses.

This volume of Progress in Heterocyclic Chemistry(PHC) is the thirteenth annual review of the literature, covering the work published on important heterocyclic ring systems during 2000. In this volume there are two specialized reviews. The first, by H. Ila, H. Junjappa and P.K. Mohanta, covers their work on annulation using ∝-oxoketene dithioacetals, a synthetic method that provides useful routes to an impressively wide range of fused heterocycles. The second, by R. N. Warrener, is on the synthesis of fused 7-azanorbornanes. The 7-azanorbornane structural unit is incorporated into a series of elegant polycyclic molecules with rigid geometry. The subsequent chapters, arranged by increasing heterocycle ring size, review recent advances in the field of heterocyclic chemistry with emphasis on synthesis and reactions.