Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection

Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection
Author :
Publisher : Springer Science & Business Media
Total Pages : 374
Release :
ISBN-10 : 9781402082313
ISBN-13 : 1402082312
Rating : 4/5 (13 Downloads)

Synopsis Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection by : Alexzander A.A. Asea

With the prevalence of neurodegenerative diseases on the rise as average life expectancy increases, the hunt for effective treatments and preventive measures for these disorders is a pressing challenge. Neurodegenerative disorders such as Alzheimer’s disease, Huntington’s disease, Parkinson’s disease and amyotrophic lateral sclerosis have been termed ‘protein misfolding disorders’ that are char- terized by the neural accumulation of protein aggregates. Manipulation of the cellular stress response involving the induction of heat shock proteins offers a the- peutic strategy to counter conformational changes in neural proteins that trigger pathogenic cascades resulting in neurodegenerative diseases. Heat shock proteins are protein repair agents that provide a line of defense against misfolded, aggregati- prone proteins. Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection reviews current progress on neural heat shock proteins (HSP) in relation to neurodegenerative diseases (Part I), neuroprotection (Part II), ext- cellular HSP (Part III) and aging and control of life span (Part IV). Key basic and clinical research laboratories from major universities and hospitals around the world contribute chapters that review present research activity and importantly project the field into the future. The book is a must read for researchers, postdoctoral fellows and graduate students in the fields of Neuroscience, Neurodegenerative Diseases, Molecular Medicine, Aging, Physiology, Pharmacology and Pathology.

Molecular and Cellular Biology of Neuroprotection in the CNS

Molecular and Cellular Biology of Neuroprotection in the CNS
Author :
Publisher : Springer
Total Pages : 0
Release :
ISBN-10 : 1461349346
ISBN-13 : 9781461349341
Rating : 4/5 (46 Downloads)

Synopsis Molecular and Cellular Biology of Neuroprotection in the CNS by : Christian Alzheimer

Given the very limited capacity of regeneration in the brain, protecting neurons that are on the brink of death is a major challenge for basic and clinical neuroscience, with implications for a broad spectrum of acute and chronic neurological and psychiatric diseases. This book brings together leading experts from neurobiology, neurophysiology, neuropharmacology, neuroimmunology and clinical neuroscience to highlight the most recent milestones in this rapidly evolving field. The book will serve as a reference for both basic neuroscientists and clinicians interested in an authoritative update on the molecular and cellular biology of neuroprotection and its promises for new therapeutic strategies.

Heat Shock Proteins in Neuroscience

Heat Shock Proteins in Neuroscience
Author :
Publisher : Springer Nature
Total Pages : 304
Release :
ISBN-10 : 9783030242855
ISBN-13 : 3030242854
Rating : 4/5 (55 Downloads)

Synopsis Heat Shock Proteins in Neuroscience by : Alexzander A. A. Asea

The book Heat Shock Proteins in Neuroscience provides the most comprehensive review on contemporary knowledge on the role of HSP in signaling pathways relevant to a number of diseases. Using an integrative approach, the contributors provide a synopsis of novel mechanisms, signal transduction pathways. To enhance the ease of reading and comprehension, this book has been subdivided into various section including; Section I, reviews current progress on our understanding of Neurological Aspects of HSP; Section II, focuses on Aspects of HSP in Neurodegenerative Diseases and Disorders, Section III, emphasizes the importance of HSP in Multiple Sclerosis; Section IV, reviews critical Aspects of HSP in Alzheimer’s Disease and Section V, gives a comprehensive update of the Development of HSP-Based Therapies for Neurological Disorders. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for starters and professionals in the fields of Neurology and Neurosciences, Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

Oxidative Stress and Neurodegenerative Disorders

Oxidative Stress and Neurodegenerative Disorders
Author :
Publisher : Elsevier
Total Pages : 795
Release :
ISBN-10 : 9780080489490
ISBN-13 : 0080489494
Rating : 4/5 (90 Downloads)

Synopsis Oxidative Stress and Neurodegenerative Disorders by : G. Ali Qureshi

Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders.* Contains the latest information on the subject of neurodegenerative disorders* Reflects on various factors involved in degeneration and gives suggestions for how to tackle these problems

Heat Shock Protein-Based Therapies

Heat Shock Protein-Based Therapies
Author :
Publisher : Springer
Total Pages : 389
Release :
ISBN-10 : 9783319172118
ISBN-13 : 3319172115
Rating : 4/5 (18 Downloads)

Synopsis Heat Shock Protein-Based Therapies by : Alexzander A.A. Asea

The book Heat Shock Protein-Based Therapies provides the most up-to-date review on new heat shock protein-based mechanisms used in the therapy and treatment of various human disorders and diseases, including cancer, muscular atrophy, neurodegenerative disorders (Alzheimer's Disease, Multiple Sclerosis) and infectious diseases (HIV, periodontal disease). Written by leaders in the field of heat shock protein research, the chapters systematically and in a step wise fashion takes the reader through the fascinating sequence of events by which mechanisms dependent on heat shock proteins are targeted. The chapters also provide answers as to HSP biological significance to the host. This book is a must read for graduate and postgraduates in the field of Drug Development, Biotechnology, Pharmaceutical Industry, Phytomedicine, Biology (plant and mammal), Biochemistry (pro- and eukaryotic), Oncology, Immunology, Microbiology, Exercise Medicine, Physiology, Inflammatory diseases, Autoimmunity, Pharmacology and Pathology.

Immunity, Tumors and Aging: The Role of HSP70

Immunity, Tumors and Aging: The Role of HSP70
Author :
Publisher : Springer Science & Business Media
Total Pages : 145
Release :
ISBN-10 : 9789400759435
ISBN-13 : 9400759436
Rating : 4/5 (35 Downloads)

Synopsis Immunity, Tumors and Aging: The Role of HSP70 by : Igor Malyshev

The book is dedicated to the topical area of biology and medicine and the role of stress proteins HSP70 in the regulation of intracellular protein homeostasis, signaling transduction and cell protection. The book is divided into chapters, which describe the discovery of HSP70 and its molecular structure, the mechanism of the synthesis and function in normal and damaged cells, examine the role of HSP70 in immunity, cancerogenesis, aging, Alzheimer's disease and cardiac surgery. In this book, the author looks at HSP70 as a factor which prevents the transformation of homeostasis mechanisms of intracellular proteins into a link in the pathogenesis of a disease.

Brain Aging

Brain Aging
Author :
Publisher : CRC Press
Total Pages : 413
Release :
ISBN-10 : 9781420005523
ISBN-13 : 1420005529
Rating : 4/5 (23 Downloads)

Synopsis Brain Aging by : David R. Riddle

Recognition that aging is not the accumulation of disease, but rather comprises fundamental biological processes that are amenable to experimental study, is the basis for the recent growth of experimental biogerontology. As increasingly sophisticated studies provide greater understanding of what occurs in the aging brain and how these changes occur

Redox Proteomics

Redox Proteomics
Author :
Publisher : John Wiley & Sons
Total Pages : 978
Release :
ISBN-10 : 9780471973119
ISBN-13 : 0471973114
Rating : 4/5 (19 Downloads)

Synopsis Redox Proteomics by : Isabella Dalle-Donne

Methodology and applications of redox proteomics The relatively new and rapidly changing field of redox proteomics has the potential to revolutionize how we diagnose disease, assess risks, determine prognoses, and target therapeutic strategies for people with inflammatory and aging-associated diseases. This collection brings together, in one comprehensive volume, a broad array of information and insights into normal and altered physiology, molecular mechanisms of disease states, and new applications of the rapidly evolving techniques of proteomics. Written by some of the finest investigators in this area, Redox Proteomics: From Protein Modifications to Cellular Dysfunction and Diseases examines the key topics of redox proteomics and redox control of cellular function, including: * The role of oxidized proteins in various disorders * Pioneering studies on the development of redox proteomics * Analytical methodologies for identification and structural characterization of proteins affected by oxidative/nitrosative modifications * The response and regulation of protein oxidation in different cell types * The pathological implications of protein oxidation for conditions, including asthma, cardiovascular disease, diabetes, preeclampsia, and Alzheimer's disease Distinguished by its in-depth discussions, balanced methodological approach, and emphasis on medical applications and diagnosis development, Redox Proteomics is a rich resource for all professionals with an interest in proteomics, cellular physiology and its alterations in disease states, and related fields.

Cell Stress Proteins

Cell Stress Proteins
Author :
Publisher : Springer Science & Business Media
Total Pages : 464
Release :
ISBN-10 : 9780387397177
ISBN-13 : 0387397175
Rating : 4/5 (77 Downloads)

Synopsis Cell Stress Proteins by : Stuart K. Calderwood

This book surveys the current knowledge concerning the expression and function of stress proteins in different organisms, ranging from prokaryotes to humans. It provides an overview of the diversity and complex evolutionary history of cell stress proteins and describes their function and expression in different eukaryote models. The book will appeal to researchers and scientists in biochemistry, cell biology, microbiology, immunology, and genetics.

Nature's Robots

Nature's Robots
Author :
Publisher : OUP Oxford
Total Pages : 312
Release :
ISBN-10 : 9780191578519
ISBN-13 : 0191578517
Rating : 4/5 (19 Downloads)

Synopsis Nature's Robots by : Charles Tanford

Proteins are amazingly versatile molecules. They make the chemical reactions happen that form the basis for life, they transmit signals in the body, they identify and kill foreign invaders, they form the engines that make us move, and they record visual images. All of this is now common knowledge, but it was not so a hundred years ago. Nature's Robots is an authoritative history of protein science, from the origins of protein research in the nineteenth century, when the chemical constitution of 'protein' was first studied and heatedly debated and when there was as yet no glimmer of the functional potential of substances in the 'protein' category, to the determination of the first structures of individual proteins at atomic resolution - when positions of individual atoms were first specified exactly and bonding between neighbouring atoms precisely defined. Tanford and Reynolds, who themselves made major contributions to the golden age of protein science, have written a remarkably vivid account of this history. It is a fascinating story, involving heroes from the past, working mostly alone or in small groups, usually with little support from formal research groups. It is also a story that embraces a number of historically important scientific controversies. Written in clear and accessible prose, Nature's Robots will appeal to general readers with an interest in popular science, in addition to professional scientists and historians of science.