This book describes the experience over 25 years of the senior author with the chemistry of organic free radicals. It begins with a mechanistic study of industrial importance on the pyrolysis of chlorinated alkanes. It continues with a theory on the biosynthesis of phenolate derived alkaloids involving phenolate radical coupling. There follows 20 years of practical work to prove the theory correct, especially in the case of morphine alkaloids. The book then describes the work on nitrile photolysis (Barton reaction) which involved the invention of new radical chemistry leading to a simple synthesis of the important hormone, aldosterone. There follows a description of the invention of an important new method for the deoxygenation of biologically important molecules, especially sugars and nucleosides, using radical chemistry applied to thiocarbonyl derivatives. Some years later, in a logical extension to carboxylic acids, another new reaction was invented which provides carbon, nitrogen, oxygen and other radicals under mild conditions. A final chapter summarizes recent applications of thiocarbonyl group derived radical reactions by other authors.

Radicals and radical ions are important intermediates with wide use in organic synthesis. The first book to concentrate on reagents for the creation and use of radicals and radical ions, this new volume in the Handbooks of Reagents for Organic Synthesis series compiles articles taken from the e-eros database, on reagents for use in radical and radical chemistry, to help the chemist in the lab choose the right reagents. Reflecting the enormous growth of radical chemistry over the past ten years, this is an essential guide for all synthetic chemists.

The focus of this volume by Professor Russell is the history of organic chemistry, which arose improbably out of early speculations about the construction of chemical compounds, and in particular their electrochemical nature. The rise of electrochemistry and the work of Berzelius were critical in this regard, and receive much attention in the first few chapters in this book. Aspects of the contributions of Frankland (fully explored elsewhere) and those of Kekulê and Hofmann are considered, together with the miscellaneous functions of organic synthesis and the origins of conformational analysis. Questions of chemical organisation are germane to the whole sequence of events and are briefly summarized before the whole last hundred years of organic chemistry are placed in historical perspective.

In recent years silicon-centered radicals have played an important role in organic synthesis, polymer chemistry and material sciences. The aim of this book is to offer for the first time a description of silyl radicals within an interdisciplinary context, connecting structural characteristics and chemical properties to their application in different areas of chemistry. The first time different aspects of silyl radicals have been brought together Excellent reference tool for experienced practitioners of radical and/or silicon chemistry Presents various aspects of these intermediates in an original, comprehensive fashion This book is essential for anyone working in free radical and/or silicon chemistry as well as for those who want to approach these fields for the first time.

This practical, concise guide showcases the sustainable methods offered by green free radical chemistry and summarizes the fundamental science involved.

The second edition of this best-selling handbook is bigger, more comprehensive, and now completely current. In addition to thorough updates to the discussions featured in the first edition, this edition includes 66 new chapters that reflect recent developments, new applications, and emerging areas of interest. Within the handbook's 145 critically r

This book provides an historical overview of the recent developments in the history of diverse fields within chemistry. It follows on from Recent Developments in the History of Chemistry, a volume published in 1985. Covering chiefly the last 20 years, the primary aim of Chemical History: Reviews of the Recent Literature is to familiarise newcomers to the history of chemistry with some of the more important developments in the field. Starting with a general introduction and look at the early history of chemistry, subsequent chapters go on to investigate the traditional areas of chemistry (physical, organic, inorganic) alongside analytical chemistry, physical organic chemistry, medical chemistry and biochemistry, and instruments and apparatus. Topics such as industrial chemistry and chemistry in national contexts, whilst not featuring as separate chapters, are woven throughout the content. Each chapter is written by experts and is extensively referenced to the international chemical literature. Chemical History: Reviews of the Recent Literature is also ideal for chemists who wish to become familiar with historical aspects of their work. In addition, it will appeal to a wider audience interested in the history of chemistry, as it draws together historical materials that are widely scattered throughout the chemical literature.

Covers the vastly expanding subject of oxidative processes mediated by copper ions within biological systems Copper-mediated biological oxidations offer a broad range of fundamentally important and potentially practical chemical processes that cross many chemical and pharmaceutical disciplines. This newest volume in the Wiley Series on Reactive Intermediates in Chemistry and Biology is divided into three logical areas within the topic of copper/oxygen chemistry— biological systems, theory, and bioinorganic models and applications—to explore the biosphere for its highly evolved and thus efficient oxidative transformations in the discovery of new types of interactions between molecular oxygen and copper ion. Featuring a diverse collection of subject matter unified in one complete and comprehensive resource, Copper-Oxygen Chemistry probes the fundamental aspects of copper coordination chemistry, synthetic organic chemistry, and biological chemistry to reveal both the biological and chemical aspects driving the current exciting research efforts behind copper-oxygen chemistry. In addition, Copper-Oxygen Chemistry: Addresses the significantly increasing literature on oxygen-atom insertion and carbon-carbon bond-forming reactions as well as enantioselective oxidation chemistries Progresses from biological systems to spectroscopy and theory, and onward to bioinorganic models and applications Covers a wide array of reaction types such as insertion and dehydrogenation reactions that utilize the cheap, abundant, and energy-containing O2 molecule With thorough coverage by prominent authors and researchers shaping innovations in this growing field, this valuable reference is essential reading for bioinorganic chemists, as well as organic, synthetic, and pharmaceutical chemists in academia and industry.

The understanding of amine chemistry is of paramount importance to numerous chemical industries, as well as academic research. This book provides an authoritative account of the properties and applications of amines with respect to the characteristics of bonded substituents and the nature of their surrounding chemical and physical environments. The synthesis of alkyl, aryl and heterocyclic amines and inorganic amines with a review of their typical reactions is comprehensively treated, whilst practical synthetic and analytical methods for laboratory preparation and detection are provided. The importance of amine chemistry from the nineteenth century to the modern day, with a brief history of the development of ammonia synthesis, is included.

The Bartonian Legacy is a collection of memoirs, reminiscences and biographical details regarding Sir Derek Barton (1918-1998) who was one of the most influential organic chemists of the 20th Century. The chapters are contributed by some of his many students, coworkers and scientific colleagues, all of whom testify to his fascinating character and true genius. It offers intimate glimpses at Sir Derek's scientific life, his sense of humor and his modus operandi as a teacher of research methods. The volume will serve as a valuable companion work to the more official biographies and obituaries, several of which have already been published./a