Glutathione Centennial: Molecular Perspectives and Clinical Implications is a collection of papers presented at the international symposium by the same titles, held in Osaka, Japan on December 1-4, 1988. This symposium concentrates on the developments is glutathione field, especially those related to molecular and clinical problems. This book is organized into five parts encompassing 30 chapters. Part I deals with the metabolic regulation, thermodynamic and kinetic properties, and enzyme regulation of glutathione. Part II examines the gene expression and molecular mechanism of glutathione-related enzymes, while Part III explores the association between carcinogenesis, xenobiotic compounds, and glutathione. Part IV highlights the clinical implications of glutathione, particularly its effect on vasospasm in subarachnoid hemorrhage and experimental hepatitis. Part V discusses the mechanism and regulation of biological transport of glutathione. This book will be of great value to glutathione enthusiasts and to many scientists in the brad fields of biology and medicine, and to their students.

Preclinical and Clinical Modulation of Anticancer Drugs focuses on the theoretical and practical approaches to designing and enacting modulation principles. Each class of anticancer drug and the different types of modulators used within each drug class are discussed within individual chapters. The molecular and biochemical rationale for the use of specific modulators is discussed in detail, and preclinical and clinical implications of the data are integrated into each chapter. Mechanisms of drug resistance and the reasons behind circumventing the resistant phenotype are covered. The book will interest cancer chemotherapists, pharmacologists, oncologists, biochemists, and experimental therapeutics researchers, in addition to students studying the principles of drug discovery and protocol design.

This second edition looks at the physiologic, biochemical, and morphologic characteristics of hepatotoxicity and includes an analysis of techniques in molecular biology and immunochemistry, among others contributing to the growth in understanding of the toxic events involved. It focuses on clinical characterization of chemical hepatotoxicity, micro

The critically ill patient in intensive care may present with serious metabolic alterations caused directly by the illness or secondarily by complications (e.g. infections, organ failure or sepsis) developing within a few hours of hospitaliza tion or in the following days. Among the situations which maintain and further trigger rapidly evolving altered metabolism are complex hormonal reactions, particularly those of the hypothalamus-hypophysis-adrenal axis, and abnormal stimulation of the autonomic nervous system. In fact, the sympathetic nervous system is known to cause significant metabolic alterations. For example, a surgery patient afflicted by septic complications may become hypercatabolic and experience significant nitrogen loss; the altered protein metabolism may in turn heavily influence carbohydrate and lipid metabolism as well. Thus, it is apparent that for optimal care of patients with altered metabolic functions, further knowledge is necessary regarding the physiopathology of metabolism and the physiopathological mechanisms, which alter the consump tion of principal energy substrates. Many experimental and clinical studies have investigated the metabolic aspects of individual organs or organ systems. However, for a correct evaluation of such metabolic events, in addition to studying the roles of metabolic enzymes, active metabolites, and the glutathione system, it is interesting to consider the use of indirect calorimetry as a valid and important investigative technique. The critically ill patient with major alterations in nutritional status may require artificial nutritive support administered through either parenteral or enteral routes.

Biochemical and Molecular Aspects of Selected Cancers, Volume I provides an overview of important topics and prototypes in cancer research. The book consists of papers provided by outstanding investigators in diverse disciplines in different areas of cancer research. This volume focuses on topics relevant to cancers in humans. It covers such topics as tumor-suppressor genes and human neoplasia; protein kinase C in neoplastic cells; and extracellular matrix interactions with tumor-progressing cells: tumor versus cell type-specific mechanisms. Structural and functional characteristics of human melanoma; steroid hormones and hormone receptors in neoplastic diseases; and patterns and significance of genetic changes in neuroblastomas are expounded as well. Oncologists, biochemists, cytologists, and other researchers in allied fields will find the book invaluable.

Since biological tissues are unstable in an oxygen atmosphere, a great deal of effort is expended by organisms to metabolically limit or repair oxidative tissue damage. This volume of Methods in Enzymology and its companion Volume 234 present methods developed to investigate the roles of oxygen radicals and antioxidants in disease. Key Features* Generation, detection, and characterization of oxygen radicals, chemistry, biochemistry, and intermediate states of reductio* Isolation, characterization, and assay of enzymes or substrates involved in formation or removal of oxygen radical* Methods for assessing molecular, cell, and tissue damage; assays and repair of oxidative damage.

Ward off life-threatening disease and symptoms of aging with this guide to boosting your levels of glutathione (GSH), the "master antioxidant." The body has a remarkable ability to ward off disease and heal itself--and it does it with the help of the most important antioxidant you've never heard of: glutathione (GSH), the "master antioxidant." This indispensable molecule--which we make ourselves--holds the key to immunity, vitality, and lifelong health, helping to flush out toxins, fight DNA-damaging free radicals, and rebuild other essential antioxidants like Vitamins C and E. It's been linked to longevity in centenarians, and it protects against diseases like cancer, diabetes, and Alzheimer's. It plays a role in lesser ailments too: low glutathione levels could be the culprit behind your fatigue, aches, and pains. At the forefront of the latest GSH research, Dr. Nayan Patel shares all the information you need to boost your glutathione levels, revitalize your body, and transform your life with this naturally-occurring super antioxidant. In The Glutathione Revolution, he addresses the most important questions about GSH: What exactly is glutathione? What happens when your GSH levels are low? What diseases does GSH ward off? How can you naturally increase the amount of GSH your cells produce? What foods should you eat--and not eat? What are the safest and most effective GSH supplements? With a wealth of practical information and three easy, accessible action plans that you can tailor to your own life and health concerns, you too can harness the power of glutathione.

First multi-year cumulation covers six years: 1965-70.

This volume provides an authoritative, comprehensive view of the most current issues in brain pathophysiology and offers a critical evaluation of antioxidant-based therapeutic approaches to neurodegeneration, providing an up-to-date account of the role of antioxidants in the prevention and moderation of clinical symptoms. Examines free radicals in spinal cord damage, subarachnoid hemorrhage, reperfusion damage, and cytotoxicity! With over 2400 references, tables, drawings, photographs, and micrographs, Free Radicals in Brain Pathophysiology focuses on important biological signaling molecules such as superoxide anion and nitric oxide evaluates the action of low levels of oxygen- and nitrogen-centered radicals on cell membranes and receptors to modulate signal transduction pathways and gene expression links high mitochondrial density in neural tissue to brain disease considers how prions and -amyloid proteins influence the level of free radicals within cells assesses the abnormalities of superoxide dismutase in the familial form of amyotrophic lateral sclerosis highlights the occurrence of oxidative stress and the impact of oxidative injury in brain physiology and neurodegeneration and more! With contributions from nearly 70 internationally recognized researchers, physiologists, and clinicians who describe their latest findings and provide new insights into the factors underlying neurological disorders, Free Radicals in Brain Pathophysiology is an unsurpassed reference for nutritionists and dietitians, clinical neurologists, pathologists, cell biologists and biochemists, cardiologists, oncologists, dermatologists, and graduate and medical school students in these disciplines.

The gastrointestinal tract has a number of unique features. Its extensive surface is formed by a single layer of rapidly renewing cells, the intestinal epithelial cells. These cells are in contact with a number of other cell populations, including the largest part of the immune system, and with an excessive luminal antigen load, including vast numbers of bacteria. Furthermore two more organs, namely liver and pancreas, are part of the system. The rapid renewal of the epithelial layer, the interactions of different cell types, and the balance between cell proliferation and death, have been fascinating subjects of studies in recent years. Much has been learned, and cytokines have emerged as important mediators for all these interactions and homeostatic systems. This book, the proceedings of the Falk Symposium 113 on `Cytokines and Cell Homeostasis in the Gastrointestinal Tract', held in Regensburg, Germany, 16-18 September 1999, provides a forum for basic scientists and interested clinicians to exchange ideas, to discuss concepts and to plan further studies.