Genetics Of Epilepsy
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Author |
: |
Publisher |
: Elsevier |
Total Pages |
: 346 |
Release |
: 2014-09-04 |
ISBN-10 |
: 9780444633330 |
ISBN-13 |
: 0444633332 |
Rating |
: 4/5 (30 Downloads) |
Synopsis Genetics of Epilepsy by :
The book chapters cover different aspects of epilepsy genetics, starting with the "classical" concept of epilepsies as ion channel disorders. The second part of the book gives credit to the fact that by now non-ion channel genes are recognized as equally important causes of epilepsy. The concluding chapters are designed to offer the reader insight into current methods in epilepsy research. Each chapter is self-contained and deals with a selected topic of interest. - Authors are the leading experts in the field of epilepsy research - Book covers the most important aspects of epilepsy - Interesting for both scientists and clinicians
Author |
: Jeffrey Noebels |
Publisher |
: OUP USA |
Total Pages |
: 1258 |
Release |
: 2012-06-29 |
ISBN-10 |
: 9780199746545 |
ISBN-13 |
: 0199746540 |
Rating |
: 4/5 (45 Downloads) |
Synopsis Jasper's Basic Mechanisms of the Epilepsies by : Jeffrey Noebels
Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.
Author |
: Simon Shorvon |
Publisher |
: Cambridge University Press |
Total Pages |
: 1013 |
Release |
: 2019-05-02 |
ISBN-10 |
: 9781108420754 |
ISBN-13 |
: 1108420753 |
Rating |
: 4/5 (54 Downloads) |
Synopsis The Causes of Epilepsy by : Simon Shorvon
Expanded and revised, this unique book provides concise descriptions of the many causes of epilepsy, for use in clinical practice.
Author |
: Gregory D. Cascino |
Publisher |
: John Wiley & Sons |
Total Pages |
: 648 |
Release |
: 2021-02-22 |
ISBN-10 |
: 9781119432005 |
ISBN-13 |
: 1119432006 |
Rating |
: 4/5 (05 Downloads) |
Synopsis Epilepsy by : Gregory D. Cascino
Designed to provide a comprehensive but accessible introduction to epilepsy and seizure disorders, Epilepsy, 2nd edition provides state-of-the-art information in a concise format useful to a wide audience, from neurology residents to epilepsy fellows and practitioners. This illustrated guide to the assessment, diagnosis, and treatment of epilepsy is a valuable resource enabling clinicians to stay on top of the latest recommendations for best practice.
Author |
: Chrysostomos P. Panayiotopoulos |
Publisher |
: Springer |
Total Pages |
: 570 |
Release |
: 2005 |
ISBN-10 |
: UOM:39015062497741 |
ISBN-13 |
: |
Rating |
: 4/5 (41 Downloads) |
Synopsis The Epilepsies by : Chrysostomos P. Panayiotopoulos
This book gives an exhaustive account of the classification and management of epileptic disorders. It provides clear didactic guidance on the diagnosis and treatment of epileptic syndromes and seizures through thirteen chapters, complemented by a pharmacopoeia and CD ROM of video-EEGs.
Author |
: |
Publisher |
: Elsevier |
Total Pages |
: 480 |
Release |
: 2018-01-29 |
ISBN-10 |
: 9780444640772 |
ISBN-13 |
: 0444640770 |
Rating |
: 4/5 (72 Downloads) |
Synopsis Neurogenetics, Part II by :
Neurogenetics, Part II, Volume 148, the latest release in the Handbook of Clinical Neurology, provides the latest information on the genetic methodologies that are having a significant impact on the study of neurological and psychiatric disorders. Using genetic science, researchers have identified over 200 genes that cause or contribute to neurological disorders. Still an evolving field of study, defining the relationship between genes and neurological and psychiatric disorders is expected to dramatically grow in scope. Part II builds on the foundation of Part I, expanding the coverage to dementias, paroxysmal disorders, neuromuscular disorders, white matter and demyelination diseases, cerebrovascular diseases, adult psychiatric disorders and cancer and phacomatoses. - Contains comprehensive coverage of neurogenetics - Details the latest science and its impact on our understanding of neurological, psychiatric disorders - Presents a focused reference for clinical practitioners and the neuroscience/neurogenetics research community
Author |
: Antonio V. Delgado-Escueta |
Publisher |
: Lippincott Williams & Wilkins |
Total Pages |
: 368 |
Release |
: 2005 |
ISBN-10 |
: 0781752485 |
ISBN-13 |
: 9780781752480 |
Rating |
: 4/5 (85 Downloads) |
Synopsis Myoclonic Epilepsies by : Antonio V. Delgado-Escueta
This volume is the first comprehensive text and clinical reference on idiopathic myoclonic epilepsies of infancy, childhood, adolescence, and adulthood. The world’s foremost experts describe the phenotypes and subtypes of myoclonic epilepsies and the underlying molecular defects and summarize cutting-edge advances in molecular genetics that shed new light on the etiologies of these syndromes. The book offers clinicians much-needed assistance in recognizing and diagnosing idiopathic myoclonic epilepsies and selecting appropriate treatment. Each chapter includes diagnostic and treatment algorithms to guide practitioners in clinical decision making.
Author |
: Alberto Lazarowski |
Publisher |
: Biota Publishing |
Total Pages |
: 121 |
Release |
: 2013-03-01 |
ISBN-10 |
: 9781615045334 |
ISBN-13 |
: 1615045333 |
Rating |
: 4/5 (34 Downloads) |
Synopsis Genetics of Epilepsy and Refractory Epilepsy by : Alberto Lazarowski
Epilepsy affects approximately 3% of the population, and is usually defined as a tendency to experience recurrent seizures arising from periodic neuronal hyperexcitability of unknown causes. Different genetic factors, through various mechanisms, can cause this abnormal neuronal behavior. The etiology of epilepsy is a major determinant of clinical course and prognosis. Many of the genes that have been implicated in idiopathic epilepsies code for ion channels, whereas a wide spectrum of syndromes where epilepsy is a main clinical feature are caused by mutated genes that are involved in functions as diverse as cortical development, brain malformations, mitochondrial function, and cell metabolism. Similarly, different conditions as hypoxia, trauma, infections, or metabolic unbalances can develop epileptic syndromes where upregulation of several genes could be related to the epileptogenic mechanisms. The most common human genetic epilepsies display a complex pattern of inheritance, and the susceptible genes are largely unknown. However, major advances have recently been made in our understanding of the genetic basis of monogenic inherited epilepsies. As we continue to unravel the molecular genetic basis for epilepsies, it will increasingly influence their classification and diagnosis. A majority of epileptic patients may control their crisis with anticonvulsant drugs, however 30%–40% became refractory to pharmacological therapies and require surgical treatment. The challenge of the molecular revolution will be the design of the best treatment protocols based on genetic profiles that include both the specific mechanistic etiology of the epilepsies, as well as their potential refractory behavior to current medications. This includes also the design of new therapeutic agents and targets, so as to reduce the number of cases with refractory epilepsy and epileptogenesis, and perhaps avoid the current surgical treatment (a procedure that was first described more than 4000 years ago) except as a last option.
Author |
: Bureau Michelle |
Publisher |
: John Libbey Eurotext |
Total Pages |
: 682 |
Release |
: 2012-11-12 |
ISBN-10 |
: 9782742008292 |
ISBN-13 |
: 2742008292 |
Rating |
: 4/5 (92 Downloads) |
Synopsis Epileptic Syndromes in Infancy, Childhood and Adolescence - 5th edition by : Bureau Michelle
The ultimate reference book : the 5th updated edition of the famous “blue guide”. Incluided : A DVD with new sequences completes each chapter! Epileptology changes. The syndromic approach is completed by an etiological approach, based on the major advances in genetics and functional genetics. New entities have found their place, and a purely descriptive, “electroclinical” approach is no longer adapted in many circumstances. The 5th edition of the Blue Guide includes the most recent advances. It was necessary to justify the physiological, epidemiologic, genetic and therapeutic approaches and to consider them in the light of the new classification efforts, which are still in the making. Nevertheless, the description of epileptic syndromes, both classical and recent, remains at the core of this book.
Author |
: Luisa Rocha |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 333 |
Release |
: 2014-07-08 |
ISBN-10 |
: 9781461464648 |
ISBN-13 |
: 1461464641 |
Rating |
: 4/5 (48 Downloads) |
Synopsis Pharmacoresistance in Epilepsy by : Luisa Rocha
Although more than 10 new antiepileptic drugs have been developed in the past decade, epilepsy remains resistant to drug therapy in about one third of patients, many of whom struggle with the disease their entire lives. Managing these patients is a challenge and requires a structured multidisciplinary approach. The book includes chapters on all issues related to pharmacoresistance in epilepsy and describes recent developments in the pathogenesis and treatment of this disorder. It addresses abnormalities in inhibitory mechanisms, epilepsy-related changes to the immune system, development of pharmacoresistance caused by chronic exposure to antiepileptic drugs, and novel therapeutic strategies for preventing or slowing down the progression of the disease. Clinicians and basic scientists alike will find up-to-date information on the development of pharmacoesistance, as well as reviews of mechanisms associated with epilepsy that may help them consider novel strategies for preventing the development of pharmacoresistance in the first place. The book also features information on new therapeutic strategies for control of epilepsy, such as transcutaneous electrical stimulation and virtual screening of new antiepileptic drugs. Pharmacoresistance in Epilepsy: From Genes and Molecules to Promising Therapies is useful to anyone working in the field, whether they’re studying epilepsy in the lab or treating it in a doctor’s office.”