Completely revised new edition of the definitive reference on disorders of hemoglobin.

Over the past century, we have made great strides in reducing rates of disease and enhancing people's general health. Public health measures such as sanitation, improved hygiene, and vaccines; reduced hazards in the workplace; new drugs and clinical procedures; and, more recently, a growing understanding of the human genome have each played a role in extending the duration and raising the quality of human life. But research conducted over the past few decades shows us that this progress, much of which was based on investigating one causative factor at a time—often, through a single discipline or by a narrow range of practitioners—can only go so far. Genes, Behavior, and the Social Environment examines a number of well-described gene-environment interactions, reviews the state of the science in researching such interactions, and recommends priorities not only for research itself but also for its workforce, resource, and infrastructural needs.

This book presents case histories to illustrate in a clinical context essential points about the mechanisms of immunity. It includes cases that illustrate both recently discovered genetic immunodeficiencies and some more familiar and common diseases with interesting immunology.

It has been recognized for almost 200 years that certain families seem to inherit cancer. It is only in the past decade, however, that molecular genetics and epidemiology have combined to define the role of inheritance in cancer more clearly, and to identify some of the genes involved. The causative genes can be tracked through cancer-prone families via genetic linkage and positional cloning. Several of the genes discovered have subsequently been proved to play critical roles in normal growth and development. There are also implications for the families themselves in terms of genetic testing with its attendant dilemmas, if it is not clear that useful action will result. The chapters in The Genetics of Cancer illustrate what has already been achieved and take a critical look at the future directions of this research and its potential clinical applications.

Biochemical and Molecular Basis of Pediatric Disease, Fifth Edition has been a well-respected reference in the field for decades. This revision continues the strong focus on understanding the pathogenesis of pediatric disease, emphasizing not only the important role of the clinical laboratory in defining parameters that change with the disease process, but also the molecular basis of many pediatric diseases. - Provides a fully-updated resource with more color illustrations - Focuses on the biochemical and molecular basis of disease as well as the analytical techniques - Defines important differences in the pathophysiology of diseases, comparing childhood with adult

Educators often face the pressure to address children's medical needs within the school setting, but sometimes find themselves having to make difficult decisions without adequate training, support, or information about important pediatric issues. When faced with a medical question, many may turn to the Internet where information is sometimes reliable, sometimes not. This concise and well-researched investigation into genetic and acquired health issues provides credibility and verifiability of data and establishes a foundation of confidence for any educator who must make policy, differentiate instruction, provide educational accommodations, offer special education services, collaborate with families, and work with the community to serve to children's medical, physical, and psychological needs. Written for school psychologists, counsellors, administrators, and teachers, this highly practical and easy-to-understand reference describes genetic, chromosomal, and acquired disorders and discusses behavioural issues that may manifest themselves in classrooms as well as treatment options and intervention strategies. Readers will find: - A section on chromosomal, genetic, and metabolic disorders covering topics such as phenylketonuria, the genetics of autism, the biology of shyness, and families of children with genetic disorders - A section on acquired disorders with chapters on prenatal alcohol exposure, prenatal exposure to antidepressants, celiac disease, maternal post-partum depression and behaviour problems, asthma and quality of life, food allergies in the classroom, and diabetes. Each chapter includes a case study, parent handouts, and a literature review based on the latest and best scientific research.

Rare diseases collectively affect millions of Americans of all ages, but developing drugs and medical devices to prevent, diagnose, and treat these conditions is challenging. The Institute of Medicine (IOM) recommends implementing an integrated national strategy to promote rare diseases research and product development.

This book offers the most up-to-date, user-friendly guidance on the evaluation, diagnosis and medical and surgical treatment of heart and vascular disease. The book and DVD package is designed to provide comprehensive coverage of every aspect of cardiovascular medicine. The book has consistent chapter organization relevant to modern cardiovascular practice, clear design and engaging text. The reader will have all the guidance to diagnose and manage the full range of cardiovascular conditions in one textbook resource, while also benefiting from access to additional video material from the integral DVD-ROM. This includes over 100 individual heart sounds.

First edition published in 2002. Second edition published in 2008.

A pioneering work that focuses on the unique diversity of African genetics, offering insights into human biology and genetic approaches.