With a Foreword by Reiter R.J. Translated by Forster, S.

1. Introduction -- 2. Phenotyping -- 3. Necropsy and histology -- 4. Mammary Gland -- 5. Skeletal System -- 6. Nose, sinus, pharynx and larynx -- 7. Oral cavity and teeth -- 8. Salivary glands -- 9. Respiratory -- 10. Cardiovascular -- 11. Upper GI -- 12. Lower GI -- 13. Liver and gallbladder -- 14. Pancreas -- 15. Endocrine System -- 16. Urinary System -- 17. Female Reproductive System -- 18. Male Reproductive System -- 19. Hematopoietic and Lymphoid Tissues -- 20. Nervous System -- 21. Special senses, eye -- 22. Special senses, ear -- 23. Skin and adnexa -- Index.

The second edition of Comparative Anatomy and Histology is aimed at the new rodent investigator as well as medical and veterinary pathologists who need to expand their knowledge base into comparative anatomy and histology. It guides the reader through normal mouse and rat anatomy and histology using direct comparison to the human. The side by side comparison of mouse, rat, and human tissues highlight the unique biology of the rodents, which has great impact on the validation of rodent models of human disease. - Offers the only comprehensive source for comparing mouse, rat, and human anatomy and histology through over 1500 full-color images, in one reference work - Enables human and veterinary pathologists to examine tissue samples with greater accuracy and confidence - Teaches biomedical researchers to examine the histologic changes in their model rodents - Experts from both human and veterinary fields take readers through each organ system in a side-by-side comparative approach to anatomy and histology - human Netter anatomy images along with Netter-style rodent images

An in-depth look at the origin and evolutionary radiation of the synapsids. About 320 million years ago a group of reptiles known as the synapsids emerged and forever changed Earth’s ecological landscapes. This book discusses the origin and radiation of the synapsids from their sail-backed pelycosaur ancestor to their diverse descendants, the therapsids or mammal-like reptiles, that eventually gave rise to mammals. It further showcases the remarkable evolutionary history of the synapsids in the Karoo Basin of South Africa and the environments that existed at the time. By highlighting studies of synapsid bone microstructure, it offers a unique perspective of how such studies are utilized to reconstruct various aspects of biology, such as growth dynamics, biomechanical function, and the attainment of sexual and skeletal maturity. A series of chapters outline the radiation and phylogenetic relationships of major synapsid lineages and provide direct insight into how bone histological analyses have led to an appreciation of these enigmatic animals as once-living creatures. The penultimate chapter examines the early radiation of mammals from their nonmammalian cynodont ancestors, and the book concludes by engaging the intriguing question of when and where endothermy evolved among the therapsids. “Ever since Nick Hotton’s book from the 1980s we have needed an update on the biology of therapsids, and it has been Anusuya Chinsamy-Turan and her students and associates who through their bone histological work have made the greatest progress in this field.” —Martin Sander, Steinmann Institute, University of Bonn “Forerunners of Mammals is full of meticulous detail . . . [I]t also contains a number of excellently rendered illustrations of some of the animals covered in the book, and the final chapter is a discussion of the evolution of endothermy that anyone with a background in biology might find of interest. . . . Recommended.” —Choice “Forerunners of Mammals will take interested readers beyond the classic jaw-to-ear appreciation of therapsids, towards a deeper appreciation of the ancestry of mammals.” —Journal of Mammalian Evolution “This volume represents a state-of-the-art contribution to our understanding of the paleobiology of how mammals arose, and what factors contributed to their evolutionary radiation and eventual success. It is highly recommended for anyone interested in these topics, and will be accessible to readers with minimal background in bone histology and synapsid paleontology.” —Quarterly Review of Biology

This atlas presents the basic concepts and principles of functional animal anatomy and histology thereby furthering our understanding of evolutionary concepts and adaptation to the environment. It provides a step-by-step dissection guide with numerous colour photographs of the animals featured. It also presents images of the major organs along with histological sections of those organs. A wide range of interactive tutorials gives readers the opportunity to evaluate their understanding of the basic anatomy and histology of the organs of the animals presented.

Anatomy and Histology of the Laboratory Rat in Toxicology and Biomedical Research presents the detailed systematic anatomy of the rat, with a focus on toxicological needs. Most large works dealing with the laboratory rat provide a chapter on anatomy, but fall far short of the detailed account in this book which also focuses on the needs of toxicologists and others who use the rat as a laboratory animal. The book includes detailed guides on dissection methods and the location of specific tissues in specific organ systems. Crucially, the book includes classic illustrations from Miss H. G. Q. Rowett, along with new color photo-micrographs. Written by two of the top authors in their fields, this book can be used as a reference guide and teaching aid for students and researchers in toxicology. In addition, veterinary/medical students, researchers who utilize animals in biomedical research, and researchers in zoology, comparative anatomy, physiology and pharmacology will find this book to be a great resource. Illustrated with over a hundred black and white and color images to assist understanding Contains detailed descriptions and explanations to accompany all images helping with self-study Designed for toxicologic research for people from diverse backgrounds including biochemistry, pharmacology, physiology, immunology, and general biomedical sciences

A Practical Guide to the Histology of the Mouse provides a full-colour atlas of mouse histology. Mouse models of disease are used extensively in biomedical research with many hundreds of new models being generated each year. Complete phenotypic analysis of all of these models can benefit from histologic review of the tissues. This book is aimed at veterinary and medical pathologists who are unfamiliar with mouse tissues and scientists who wish to evaluate their own mouse models. It provides practical guidance on the collection, sampling and analysis of mouse tissue samples in order to maximize the information that can be gained from these tissues. As well as illustrating the normal microscopic anatomy of the mouse, the book also describes and explains the common anatomic variations, artefacts associated with tissue collection and background lesions to help the scientist to distinguish these changes from experimentally- induced lesions. This will be an essential bench-side companion for researchers and practitioners looking for an accessible and well-illustrated guide to mouse pathology. Written by experienced pathologists and specifically tailored to the needs of scientists and histologists Full colour throughout Provides advice on sampling tissues, necropsy and recording data Includes common anatomic variations, background lesions and artefacts which will help non-experts understand whether histologic variations seen are part of the normal background or related to their experimental manipulation

Atlas of Histology of the Juvenile Rat should be of interest to toxicologic pathologists, toxicologists, and other biological scientists who are interested in the histomorphology of juvenile rats. For several decades the laboratory rat has been used extensively in nonclinical toxicology studies designed to detect potential human toxicity of drugs, agrochemicals, industrial chemicals, and environmental hazards. These studies traditionally have involved young adult rats that are 8-10 weeks of age as studies are started. It is becoming increasingly apparent that children and young animals may have different responses to drug/chemical exposures, therefore, regulatory agencies are emphasizing toxicology studies in juvenile animals. While the histologic features of organs from young adult and aged laboratory rats are well known, less is known about the histologic features of organs from juvenile rats. Final histologic maturity of many organs is achieved postnatally, thus immature histologic features must be distinguished from chemical- or drug-related effects. While this postnatal organ development is known to exist as a general concept, detailed information regarding postnatal histologic development is not readily available. The Atlas includes organs that are typically sampled in nonclinical toxicology studies and presents the histologic features at weekly intervals, starting at birth and extending through postnatal day 42. - Written and edited by highly experienced, board-certified toxicologic pathologists - Includes more than 700 high-resolution microscopic images from organs that are typically examined in safety assessment toxicology studies - Detailed figure legends and chapter narratives present the salient features of each organ at each time interval - Figures are available for further study via Elsevier's Virtual Microscope, which allows viewing of microscopic images at higher magnification - Valuable resource for toxicologic pathologists who are confronted with interpretation of lesions in juvenile rats in situations where age-matched concurrent controls are not available for comparison, e.g., with unscheduled decedents - Figures are available for further study on ScienceDirect with Virtual Microscope, which allows viewing of microscopic images at higher magnification

This full-color dissection guide is intended for students taking Mammalian Anatomy, Comparative Anatomy, General Biology, or Anatomy & Physiology courses and contains 175 photographs plus many full-color illustrations. The combination of a good anatomy text, clear discussions of dissection techniques, and well-executed photographs and illustrations makes this a definitive book in biology curricula.