This book provides a comprehensive overview of the use of noble metal nanoparticles for bioimaging and biosensing. It starts with a review on the synthesis, characterization, optical properties, and bioconjugation of noble metal nanoparticles, followed by introduction of various biodetection techniques based on noble metal nanoparticles. In between these topics, microfabrication of biosensing chips and the use of microfluidics to enhance biosensing performance are discussed.

Sensors and Probes for Bioimaging A fulsome exploration of the history, design, and application of bioimaging probes and sensors In Sensors and Probes for Bioimaging, distinguished researcher Professor Young-Tae Chang and Professor Nam-Young Kang deliver a comprehensive discussion of bioimaging achieved with sensors and probes. In the book, readers will find a complete discussion of the history of colorful sensors and probes, probe design and the mechanisms of staining, as well as cell and tissue application and whole-body imaging. You’ll learn how probes can be used, how to choose and use a variety of probes, and new directions in research and application in the area of sensors and probes for bioimaging. Readers will also find: A thorough introduction to bioimaging, as well as discussions of chemical sensors and probes used in bioimaging Comprehensive explorations of organelle and cell selective probes, as well as discussions of a model for organelle selectivity Practical discussions of tissue selective probes and whole-body imaging Fulsome treatments of imaging for biological function and for the diagnosis of disease, including cancer and Alzheimer’s imaging Perfect for chemical biologists, analytical chemists, biochemists, and materials scientists, Sensors and Probes for Bioimaging will also earn a place in the libraries of clinical chemists and advanced undergraduate students, graduate students, and professionals working in the bioimaging and sensor industry.

Electrochemical Biosensors summarizes fundamentals and trends in electrochemical biosensing. It introduces readers to the principles of transducing biological information to measurable electrical signals to identify and quantify organic and inorganic substances in samples. The complexity of devices related to biological matrices makes this challenging, but this measurement and analysis are critically valuable in biotechnology and medicine. Electrochemical biosensors combine the sensitivity of electroanalytical methods with the inherent bioselectivity of the biological component. Some of these sensor devices have reached the commercial stage and are routinely used in clinical, environmental, industrial and agricultural applications. - Describes several electrochemical methods used as detection techniques with biosensors - Discusses different modifiers, including nanomaterials, for preparing suitable pathways for immobilizing biomaterials at the sensor - Explains various types of signal monitoring, along with several recognition systems, including antibodies/antigens, DNA-based biosensors, aptamers (protein-based), and more

This book describes the rational design, development and application of nucleic acid amplification strategies for biosensing, bioimaging and biomedicine. It consists of fifteen chapters demonstrating the use of these strategies in various areas, including fluorescence techniques, Chemiluminescence biosensors, electrochemiluminescence biosensors, colorimetric assays, surface plasmon resonance technologies, electrochemical DNA sensors, photoelectrochemical biosensor, nanopore sensors, quartz crystal microbalance, fluorescence imaging, surface-enhanced Raman spectroscopy, in vitro and in vivo metal ions detection, theranostics and microdroplet chips. Offering a collection of reviews illustrating the latest advances in biochemical analysis and therapeutics, the book shares valuable insights into current challenges and future prospects, making it a valuable resource for a wide readership in the various fields of biosensing, bioimaging and biomedicine.

This book broadly reviews the modem techniques and significant applications of chemical sensors and biosensors. Chapters are written by experts in the field – including Professor Joseph Wang, the most cited scientist in the world and renowned expert on sensor science who is also co-editor. Each chapter provides technical details beyond the level found in typical journal articles, and explores the application of chemical sensors and biosensors to a significant problem in biomedical science, also providing a prospectus for the future.This book compiles the expert knowledge of many specialists in the construction and use of chemical sensors and biosensors including nitric oxide sensors, glucose sensors, DNA sensors, hydrogen sulfide sensors, oxygen sensors, superoxide sensors, immuno sensors, lab on chip, implatable microsensors, et al. Emphasis is laid on practical problems, ranging from chemical application to biomedical monitoring and from in vitro to in vivo, from single cell to animal to human measurement. This provides the unique opportunity of exchanging and combining the expertise of otherwise apparently unrelated disciplines of chemistry, biological engineering, and electronic engineering, medical, physiological. - Provides user-oriented guidelines for the proper choice and application of new chemical sensors and biosensors - Details new methodological advancements related to and correlated with the measurement of interested species in biomedical samples - Contains many case studies to illustrate the range of application and importance of the chemical sensors and biosensors

This book covers novel and current strategies for biosensing, from the use of nanomaterials and biological functionalized surfaces to the mathematical assessment of novel biosensors and their potential use as wearable devices for continuous monitoring. Biosensing technologies can be used in the medical field for the early detection of disease, monitoring effectiveness of treatments, detecting nervous system signals for controlling robotic prosthesis, and much more. This book includes eleven chapters that examine and discuss several strategies of biosensing, proposing mathematical designs that address the latest reported technologies.

Of all the recent discoveries in biotechnology, that of biosensor is one of those which has seen an exponential expansion over the last few years. This evolution corresponds with the increasing need for measuring devices that can follow continuously changing biological processes. Biosensors can meet this need provided that their signals include all the information necessary for an understanding of the process, especially concerning the nature and concentration of the species present in the sample medium. It is well known that sensors form the basis of all instrumental analysis systems, but they also represent the limiting factors of such systems. In this book, we restrict ourselves to the description and study of sensors, leaving aside the different aspects of signal and data treatment. We believe, however, that it is important to stress the multifaceted character of biosensors, and the applications and economic factors which follow. Biosensor construction is essentially based on the immobilization of a bioreceptor on the corresponding transducer. The reader will find that there are a large variety of techniques for immobilizing enzymes, cofactors and mediators, and even microorganisms, immunoagents, e now commercially available. Other types of tissues, and organelles. A large part of this book is devoted to enzyme biosensors are discussed, with regard to both the principles of their sensors, which is hardly surprising considering that they have been operation, and their construction.

Sensors are the eyes, ears, and more, of the modern engineered product or system- including the living human organism. This authoritative reference work, part of Momentum Press's new Sensors Technology series, edited by noted sensors expert, Dr. Joe Watson, will offer a complete review of all sensors and their associated instrumentation systems now commonly used in modern medicine. Readers will find invaluable data and guidance on a wide variety of sensors used in biomedical applications, from fluid flow sensors, to pressure sensors, to chemical analysis sensors. New developments in biomaterials- based sensors that mimic natural bio-systems will be covered as well. Also featured will be ample references throughout, along with a useful Glossary and symbols list, as well as convenient conversion tables.

A biosensor is a device for the detection of an analyte that combines a biological component with a physiochemical detector component. A typical biosensor consists of three parts: a sensitive biological element, a transducer in between and a detector element. The most widespread example of a commercial biosensor is the blood glucose biosensor, which uses an enzyme to break blood glucose down. In so doing it transfers an electron to an electrode and this is converted into a measure of blood glucose concentration. The high market demand for such sensors has fuelled development of associated sensor technologies. This book covers recent developments that combine the fields of biotechnology and electrical engineering with applications in the detection of very low levels of chemicals and biological agents in the body. It provides an authentic overview of a wide range of biosensing systems, discussing the elements of different transducers used in sensors and the selective elements that are employed. The style is relatively non-mathematical and informal in approach. The contents of the book will be ideal for graduate and postgraduate students of biotechnology, analytical and physical chemistry. It will also be invaluable to all those concerned with the environmental and biomedical applications of such biosensing systems.

Biophotonics and Biosensing: From Fundamental Research to Clinical Trials Through Advances of Signal and Image Processing brings together the knowledge of the basic principles of the field of light-biological tissue interaction, detection methods, data processing techniques, and research, diagnostic and clinical applications. It is suitable for new entrants, while also highlighting the latest developments for experts in the field. This volume includes perspectives by leading experts from the biophotonics, biomedical engineering, and data science communities. The reader will receive a basic grounding in the key theoretical principles and practical components of biophotonics and biosensing. Working principles of devices used in spectroscopy, microscopy, and optical sensing are presented along with their application domains. The reader will learn about existing microscopy-based techniques used in biomedical applications for diagnosis and get to know different signal processing algorithms as used in biophotonics. Finally, through concrete examples, including sample preparation and measurement approaches, see how the field has developed thanks to the integration of biophotonics and optical biosensing with signal processing. - Introduces key principles of light-biological tissue interactions and biosensing - Discusses how the most promising optical diagnostic methods can exploit contemporary signal and image processing algorithms and data analytics - Includes examples of clinical studies with detailed descriptions of their implementation, along with practical guidance