Biosensors are finding increasing applications in different areas. Over the last few years the areas where biosensors may be used effectively has increased dramatically. This book like the previous four books on analyte-receptor binding and dissociation kinetics by this author addresses the often neglected area. The kinetics of binding and dissociation in solution to appropriate receptors immobilized on biosensor surfaces occurs under diffusional limitations on structured surfaces. The receptors immobilized on the biosensor surface contribute to the degree of heterogeneity on the sensor chip surface.The fractal analysis examples presented throughout the book provide a convenient means to make quantitative the degree of heterogeneity present on the sensor surface, and relates it to the binding and dissociation rate coefficients. The fractal dimension is a quantitative measure of the degree of heterogeneity present on the biosensor surface. The book emphasizes medially-oriented examples. The detection of disease-related analytes is also emphasized. The intent being that if intractable and insidious diseases are detected earlier, they will be controlled better, eventually leading to a better prognosis. Chapter 3 is a new chapter that emphasizes enhancing the relevant biosensor performance parameters such as sensitivity, stability, selectivity, response time, etc.As usual, as done in previous books by this author, the last chapter provides an update of the economics involved in biosensors, and the difficulties encounters in starting-up a biosensor company.- Modelling of binding and dissociation kinetics of analyte-receptor reactions on biosensor surfaces: provides physical insights into these reactions occurring on biosensor surfaces. Very few researchers even attempt to analyze the kinetics of these types of reactions.- Fractal analysis used to model the binding and dissociation kinetics: original and unique approach.- Economic analysis provided in the last chapter: helps balance the book; besides providing much-needed information not available in the open literature.- Emphasis on improving biosensor performance parameters: helps make biosensors better.- Empahsis on medically-related analytes: helps in prognosis of diseases.

The application of biosensors is expanding in different areas. These are portable and convenient devices that permit the rapid, accurate, and reliable detection of analytes of interest present either in the atmosphere or in aqueous or in liquid phases. The detection of glucose levels in blood for the effective management of diabetes is one. Though different biosensors have been designed for an increasing number of applications, the kinetics of binding (and dissociation) of analytes by the receptors on the biosensor surfaces has not been given enough attention in the open literature. This is a very important area of investigation since it significantly impacts biosensor performance parameters such as stability, sensitivity, selectivity, response time, regenerability, etc. Binding and Dissociation Kinetics for Different Biosensor Applications Using Fractals addresses this critical need besides helping to correct or demonstrate the need to modify the present software available with commercial biosensors that determines the kinetics of analyte-receptor reactions on biosensor surfaces.* first book to provide detailed kinetic analysis of the binding and dissociation reactions that are occuring on the biosensor surface* addresses the area of analyte-receptor binding and dissociation kinetics occurring on biosensor surfaces* provides physical insights into reactions occuring on biosensor surfaces

This title brings to the attention of researchers in the industry, and in academia, the application of fractals to help in modeling the analyte/receptor binding and dissociation kinetics on biosensor surfaces.The work builds on that done in Engineering Biosensors: Kinetics and Design Applications, published by Academic Press in 2002. In particular, more examples are provided of where biosensors may be effectively used. This sequel is extremely timely, given the anticipation that the applications and reliance on biosensors will increase due to the advances in miniaturization, (wireless) communications, and the development of new materials (especially biological and chemical). Other applications of biosensors on the increase can be found in: the protection of civilian structures and infrastructures; protection from possible biological and chemical threats; health care; energy; food safety; and the environment to name a few. - Covers all areas of applications of biosensors - No other book on biosensors describes the kinetics of binding - Provides numerous examples of where biosensors may be used

Effect of Reynolds number on fractal binding kinetics on a surface-based biosensor -- DNA fractal binding and dissociation kinetics -- Fractal analysis of binding and dissociation interactions of estrogen receptors to ligands on biosensor surfaces -- A fractal analysis of analyte-estrogen receptor binding and dissociation kinetics using biosensors : environmental effects -- A fractal analysis of analyte-estrogen receptor binding and dissociation kinetics using biosensors : biomedical effects -- Fractal analysis of binding interactions of nuclear estrogen receptors occurring on biosensor surfaces -- A kinetic study of analyte-receptor binding and dissociation for biosensor applications : a fractal analysis for cholera toxin and peptide-protein interactions / -- The temporal nature of the binding and dissociation rate coefficients and the affinity values for biosensor kinetics -- Fractal analysis of analyte-receptor binding and dissociation, and dissociation alone for biosensor applicati ...

Biosensors are portable and convenient devices that permit the rapid and reliable analysis of substances. They are increasingly used in healthcare, drug design, environmental monitoring and the detection of biological, chemical, and toxic agents. Fractal Binding and Dissociation Kinetics for Different Biosensor Applications focuses on two areas of expanding biosensor development that include (a) the detection of biological and chemical pathogens in the atmosphere, and (b) biomedical applications, especially in healthcare. The author provides numerous examples of practical uses, particularly biomedical applications and the detection of biological or chemical pathogens. This book also contains valuable information dedicated to the economics of biosensors. After reading this book, the reader will gain invaluable insight into how biosensors work and how they may be used more effectively.* No other book provides a detailed kinetic analysis of the binding and dissociation reactions occurring on the biosensor surfaces* Packed with examples of practical uses of biosensors* Includes chapters dedicated to the economics of biosensors

Biosensors are essential to an ever-expanding range of applications, including healthcare; drug design; detection of biological, chemical, and toxic agents; environmental monitoring; biotechnology; aviation; physics; oceanography; and the protection of civilian and engineering infrastructures. This book, like the previous five books on biosensors by this author (and one by the co-author), addresses the neglected areas of analyte-receptor binding and dissociation kinetics occurring on biosensor surfaces. Topics are covered in a comprehensive fashion, with homogeneous presentation for the benefit of the reader. The contributors address the economic aspects of biosensors and incorporate coverage of biosensor fabrication and nanobiosensors, among other topics. The comments, comparison, and discussion presented provides a better perspective of where the field of biosensors is heading. - Serves as a comprehensive resource on biosensor analysis - Examines timely topics such as biosensor fabrication and nanobiosensors - Covers economic aspects and medical applications (e.g., the role of analytes in controlling diabetes)

Statistical Bioinformatics provides a balanced treatment of statistical theory in the context of bioinformatics applications. Designed for a one or two semester senior undergraduate or graduate bioinformatics course, the text takes a broad view of the subject – not just gene expression and sequence analysis, but a careful balance of statistical theory in the context of bioinformatics applications. The inclusion of R & SAS code as well as the development of advanced methodology such as Bayesian and Markov models provides students with the important foundation needed to conduct bioinformatics. - Integrates biological, statistical and computational concepts - Inclusion of R & SAS code - Provides coverage of complex statistical methods in context with applications in bioinformatics - Exercises and examples aid teaching and learning presented at the right level - Bayesian methods and the modern multiple testing principles in one convenient book

One major concern of biotechnology is either using enzymes or producing them. Enzyme/protein production is therefore an important starting point for biotechnology. Bioseparation or Downstream Processing constitutes about 40-90% of the total production cost. Driven by economics, highly selective technologies applicable to large-scale processing have emerged during the last decade. These technologies are slowly diffusing to enzymologists who are working on a smaller scale, looking for fast and efficient purification protocols. The affinity-based techniques (including precipitation, two-phase extractions, expanded bed chromatography, perfusion chromatography and monoliths) described in this volume provide current and new cutting-edge methods. Consequently, the book is of main interest to researchers in biochemistry, biochemical engineering and biotechnology, working either in academic or industrial sectors.

A Fractal Analysis of Chemical Kinetics with Applications to Biological and Biosensor Interfaces analyzes the kinetics of binding and dissociation of different analytes by different biosensor techniques, demonstrating, and then comparing each other. Emphasis is on newer instrumentation techniques, such as surface plasmon resonance imaging (SPRi), and classical techniques, such as surface plasmon resonance (SPR), and finally, DNA biosensors and nanobiosensors. In addition, the closing chapter includes discussion of biosensor economics. - Presents and compares different biosensor techniques - Evaluates the kinetics of binding and dissociation of different analytes on biosensor surfaces - Explores the major applications of biosensors in the field