As a leader you are not only responsible for your own productivity, but for helping those on your team be as productive as possible, and not just at work, but at home as well. Neen made this book easy to digest and implement the strategies immediately. It's not just a book of theory or unrealistic tips for someone who keeps laminated checklists for their family members. Neen provides nuggets of wisdom and then weaves in the insights from other experts that it is like 10 books rolled into one.--Back cover.

Tummy time is important for babies' physical development. It builds strength in their necks and upper bodies, eventually enabling them to roll over, sit, and crawl. Keep their brains busy too with this two-sided panorama of images designed to attract and keep their attention from birth to 12 months.

Organized by Alessandra Carbone (IHÉS, Bures-sur-Yvette, France) Organized by Misha Gromov (IHÉS, Bures-sur-Yvette, France) Organized by François Képès (CNRS-Genopole

A page-turning science-fiction thriller from the author of Paradox Bound and the Ex-Heroes series. Step into the fold. It's perfectly safe. The folks in Mike Erikson's small New England town would say he's just your average, everyday guy. And that's exactly how Mike likes it. Sure, the life he's chosen isn’t much of a challenge to someone with his unique gifts, but he’s content with his quiet and peaceful existence. That is, until an old friend presents him with an irresistible mystery, one that Mike is uniquely qualified to solve: far out in the California desert, a team of DARPA scientists has invented a device they affectionately call the Albuquerque Door. Using a cryptic computer equation and magnetic fields to “fold” dimensions, it shrinks distances so that a traveler can travel hundreds of feet with a single step. The invention promises to make mankind’s dreams of teleportation a reality. And, the scientists insist, traveling through the Door is completely safe. Yet evidence is mounting that this miraculous machine isn’t quite what it seems—and that its creators are harboring a dangerous secret. As his investigations draw him deeper into the puzzle, Mike begins to fear there’s only one answer that makes sense. And if he’s right, it may only be a matter of time before the project destroys…everything. A cunningly inventive mystery featuring a hero worthy of Sherlock Holmes and a terrifying final twist you’ll never see coming, The Fold is that rarest of things: a genuinely page-turning science-fiction thriller.

Many designers use folding techniques in their work to make three-dimensional forms from two-dimensional sheets of fabric, cardboard, plastic, metal, and many other materials. This unique book explains the key techniques of folding, such as pleated surfaces, curved folding, and crumpling. It has applications for architects, product designers, and jewelry and fashion designers An elegant, practical handbook, Folding for Designers explains over 70 techniques explained with clear step-by-step drawings, crease pattern drawings, and specially commissioned photography. All crease pattern drawings are available to view and download from the Laurence King website.

Understanding the molecular bases of human health could greatly augment our ability to prevent and treat diseases. For example, a deeper understanding of protein folding would serve as a reference point for understanding, preventing, and reversing protein misfolding in diseases like Alzheimer's. Unfortunately, the small size and tremendous flexibility of proteins and other biomolecules make it difficult to simultaneously monitor their thermodynamics and kinetics with sufficient chemical detail. Atomistic Molecular Dynamics (MD) simulations can provide a solution to this problem in some cases; however, they are often too short to capture biologically relevant timescales with sufficient statistical accuracy. We have developed a number of methods to address these limitations. In particular, our work on Markov State Models (MSMs) now makes it possible to map out the conformational space of biomolecules by combining many short simulations into a single statistical model. Here we describe our use of MSMs to better understand protein and RNA folding. We chose to focus on these folding problems because of their relevance to misfolding diseases and the fact that any method capable of describing such drastic conformational changes should also be applicable to less dramatic but equally important structural rearrangements like allostery. One of the key insights from our folding simulations is that protein native states are kinetic hubs. That is, the unfolded ensemble is not one rapidly mixing set of conformations. Instead, there are many non-native states that can each interconvert more rapidly with the native state than with one another. In addition to these general observations, we also demonstrate how MSMs can be used to make predictions about the structural and kinetic properties of specific systems. Finally, we explain how MSMs and other enhanced sampling algorithms can be used to drive efficient sampling.

Nucleic acids are the fundamental building blocks of DNA and RNA and are found in virtually every living cell. Molecular biology is a branch of science that studies the physicochemical properties of molecules in a cell, including nucleic acids, proteins, and enzymes. Increased understanding of nucleic acids and their role in molecular biology will further many of the biological sciences including genetics, biochemistry, and cell biology. Progress in Nucleic Acid Research and Molecular Biology is intended to bring to light the most recent advances in these overlapping disciplines with a timely compilation of reviews comprising each volume. Follow the new editor-in-chief, P. Michael Conn, as he introduces this second thematic volume in the series – an in-depth aid to researchers who are looking for the best techniques and tools for understanding the complexities of protein folding Understand the advantages of protein folding over other therapeutic approaches and see how protein folding plays a critical role in the development of diseases such as Alzheimer’s and diabetes Decipher the rules of protein folding through compelling and timely reviews combined with chapters written by international authors in engineering, biochemistry, physics and computer science

Information on our detailed genetic code is increasing at a dramatic pace. We need to understand how that is translated into the three-dimensional structure of proteins in order to make use of the information. Progress in this field is hampered by the lack of precise force fields and of efficient codes for finding equilibrium configurations of heteropolymers. However, there has been rapid advance in recent years, and this volume discusses that.

This text presents the results of broad, interdisciplinary effort to study proteins in physical and evolutionary perpective. Among authors are physicists, computational, chemists, crystallographers and evolutionary biologists. Experimental and theoretical developments from molecules to cells are presented, providing a broad picture of modern biophysical chemistry.