The sector of fine chemicals, including pharmaceuticals, agrochemicals, dyes and pigments, fragrances and flavours, intermediates, and performance chemicals is growing fast. For obvious reasons chemistry is a key to the success in developing new processes for fine chemicals. However, as a rule, chemists formulate results of their work as recipes, which usually lack important information for process development. Fine Chemicals Manufacture, Technology and Engineering is intended to show what is needed to make the recipe more useful for process development purposes and to transform the recipe into an industrial process that will be safe, environmentally friendly, and profitable.The goal of this book is to form a bridge between chemists and specialists of all other branches involved in the scale-up of new processes or modification of existing processes with both a minimum effort and risk and maximum profit when commercializing the process. New techniques for scale-up and optimization of existing processes and improvements in the utilization of process equipment that have been developed in recent years are presented in the book.

This book is a comprehensive reference on one of the most exciting and challenging segments of the modern chemical industry. It comprises descriptions of the leading fine chemical companies, the products, markets and technologies on a global basis. It serves also as a guide for developing and succeeding in the $60 billion fine chemicals business, which is usually lumped into the chemical or pharmaceutical industry.

The sector of fine chemicals, including pharmaceuticals, agrochemicals, dyes and pigments, fragrances and flavours, intermediates, and performance chemicals is growing fast. For obvious reasons chemistry is a key to the success in developing new processes for fine chemicals. However, as a rule, chemists formulate results of their work as recipes, which usually lack important information for process development. Fine Chemicals Manufacture, Technology and Engineering is intended to show what is needed to make the recipe more useful for process development purposes and to transform the recipe into an industrial process that will be safe, environmentally friendly, and profitable.The goal of this book is to form a bridge between chemists and specialists of all other branches involved in the scale-up of new processes or modification of existing processes with both a minimum effort and risk and maximum profit when commercializing the process. New techniques for scale-up and optimization of existing processes and improvements in the utilization of process equipment that have been developed in recent years are presented in the book.

The book gives a complete overview on today's research, development and industrialization of fine chemicals from acetylene. The author provides a comprehensive methodology by covering derivatives from acetylene reacting with formaldehyde, alcohol, ketone, halogen and acetic acid. The book offers extensive and practical reference work for chemists and chemical engineers as well as university teachers and students.

Table 1 E factors (tonnes of waste generated per tonne of product manufactured [7] Industry segment Annual product tonnage E factor 6 8 Oil refining 10 –10 Approx. 0. 1 4 6 Bulk chemicals 10 –10

In modern age chemical industries have permeated most extensively in comparison with other industries and are progressing at a very rapid pace. Chemical Industry in India is one of the fastest growing industries under the Indian economy. The chemical industry comprises the companies that produce industrial chemicals. Central to the modern world economy, it converts raw materials into more than 70,000 different products. Chemicals have contributed in various sectors like food industry, fertilizers, perfumery, fragrance and flavour etc. Chemicals are used to make a wide variety of consumer goods, as well as thousands inputs to agriculture, manufacturing, construction, and service industries. There are numerous chemicals produced in chemical industry for example chloroform, caffeine, fertilizers , dyes, drug intermediates, herbicide, inorganic salts, copper sulphate, acetaldehyde etc. The chemical industry itself consumes 26 percent of its own output. The Chemical Industry in India is based on the idea of diversification. For example inorganic chemicals is the sector where the growth rate is near about 9% and the chemicals produced in this sector are mainly used in alkalis, fertilizers, etc. Depending on the product categories the chemical industry is divided in many other sectors like drugs and pharmaceuticals, fertilizers, fine chemicals like dyes and paints etc. The chemical industry in India which generates almost 13% of total national export is growing annually at a growth rate anywhere between 10% and 12%. This book majorly deals with the molecular formula, raw materials, properties, laboratory testing, manufacturing process explained with flow diagrams and uses of the chemicals. The major contents of the book are inorganic salts, inorganic chemicals, industrial gas, fertilizers, alum, caffeine, ceramic chemicals etc. This book covers the production of more than 100 chemicals for example acetanilide, methylamine, butylamine, linalol, phosphorous, salicylic acid etc. This book should be of great value to young chemical engineers and chemists who are just entering the field but those already practicing will find much of interest and use for broadening of their insight in to fields in which they are only marginally informed. It is hoped that this book will aid to young engineers, chemical, civil, mechanical and electrical as well as chemists, in understanding the value of chemical, the type of problems met in their production and method for solving these problems. 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The tremendous progress in biology over the last half century - from Watson and Crick's elucidation of the structure of DNA to today's astonishing, rapid progress in the field of synthetic biology - has positioned us for significant innovation in chemical production. New bio-based chemicals, improved public health through improved drugs and diagnostics, and biofuels that reduce our dependency on oil are all results of research and innovation in the biological sciences. In the past decade, we have witnessed major advances made possible by biotechnology in areas such as rapid, low-cost DNA sequencing, metabolic engineering, and high-throughput screening. The manufacturing of chemicals using biological synthesis and engineering could expand even faster. A proactive strategy - implemented through the development of a technical roadmap similar to those that enabled sustained growth in the semiconductor industry and our explorations of space - is needed if we are to realize the widespread benefits of accelerating the industrialization of biology. Industrialization of Biology presents such a roadmap to achieve key technical milestones for chemical manufacturing through biological routes. This report examines the technical, economic, and societal factors that limit the adoption of bioprocessing in the chemical industry today and which, if surmounted, would markedly accelerate the advanced manufacturing of chemicals via industrial biotechnology. Working at the interface of synthetic chemistry, metabolic engineering, molecular biology, and synthetic biology, Industrialization of Biology identifies key technical goals for next-generation chemical manufacturing, then identifies the gaps in knowledge, tools, techniques, and systems required to meet those goals, and targets and timelines for achieving them. This report also considers the skills necessary to accomplish the roadmap goals, and what training opportunities are required to produce the cadre of skilled scientists and engineers needed.

Fred Aftalion's international perspective of the history of chemistry integrates the story of chemical science with that of chemical industry. This new edition includes events from 1990 to 2000, when major companies began selling off their divisions, seeking to specialize in a particular business. Aftalion explores the pitfalls these companies encountered as well as the successes of "contrarians"--those companies that remained broad and diversified. He uses BASF, Dow, and Bayer as examples of true contrarians.

Opens the door to the sustainable production of pharmaceuticals and fine chemicals Driven by both public demand and government regulations, pharmaceutical and fine chemical manufacturers are increasingly seeking to replace stoichiometric reagents used in synthetic transformations with catalytic routes in order to develop greener, safer, and more cost-effective chemical processes. This book supports the discovery, development, and implementation of new catalytic methodologies on a process scale, opening the door to the sustainable production of pharmaceuticals and fine chemicals. Pairing contributions from leading academic and industrial researchers, Sustainable Catalysis focuses on key areas that are particularly important for the fine chemical and pharmaceutical industries, including chemo-, bio-, and organo-catalytic approaches to C H, C N, and C C bond-forming reactions. Chapters include academic overviews of current innovations and industrial case studies at the process scale, providing new insights into green catalytic methodologies from proof-of-concept to their applications in the synthesis of target organic molecules. Sustainable Catalysis provides the foundation needed to develop sustainable green synthetic procedures, with coverage of such emerging topics as: Catalytic reduction of amides avoiding LiAlH4 or B2H6 Synthesis of chiral amines using transaminases Industrial applications of boric acid and boronic acid catalyzed direct amidation reactions C H activation of heteroaromatics Organocatalysis for asymmetric synthesis Offering a balanced perspective on current limitations, challenges, and solutions, Sustainable Catalysis is recommended for synthetic organic chemists seeking to develop new methodologies and for industrial chemists dedicated to large-scale process development.

Understand common scheduling as well as other advanced operational problems with this valuable reference from a recognized leader in the field. Beginning with basic principles and an overview of linear and mixed-integer programming, this unified treatment introduces the fundamental ideas underpinning most modeling approaches, and will allow you to easily develop your own models. With more than 150 figures, the basic concepts and ideas behind the development of different approaches are clearly illustrated. Addresses a wide range of problems arising in diverse industrial sectors, from oil and gas to fine chemicals, and from commodity chemicals to food manufacturing. A perfect resource for engineering and computer science students, researchers working in the area, and industrial practitioners.