Fate of Pesticides in Large Animals covers the proceedings of the 1976 Fate of Pesticides in Large Animals symposium. The symposium is held at the Centennial Meeting of American Chemical Society and sponsored by the Pesticide Chemistry Division of the ACS. It aims to focus on the fate of pesticides in large animals and to assemble a thesis on the subject covering its theoretical and practical significance. In this book, large animals are particularly considered, because they often metabolize chemicals differently than small laboratory rodents. These differences may prove a basis for the development of concepts pertinent to the phenomenon of selective toxicity. This book is divided into three sections encompassing 14 chapters. The first section delineates the rationale of the symposium and presents topics applicable to all facets of large animal metabolism. The second section focuses on comparative metabolism of selected groups of pesticides, including phenoxy herbicides, insect growth regulators, fungicides, and halogenated hydrocarbons. The third section deals with specific compounds and/or specific large animal species. It includes mirex, chlordane, dieldrin, and polychlorinated biphenyls; p,p'-DDT and p,p'-DDE in pig; phenyl N,N'-dimethylphosphorodiamidate; croneton; and Vacor rodenticide. This book is an invaluable resource for chemists, biochemists, researchers, and toxicologists.

Although chemical pesticides safeguard crops and improve farm productivity, they are increasingly feared for their potentially dangerous residues and their effects on ecosystems. The Future Role of Pesticides explores the role of chemical pesticides in the decade ahead and identifies the most promising opportunities for increasing the benefits and reducing the risks of pesticide use. The committee recommends R&D, program, and policy initiatives for federal agriculture authorities and other stakeholders in the public and private sectors. This book presents clear overviews of key factors in chemical pesticide use, including: Advances in genetic engineering not only of pest-resistant crops but also of pests themselves. Problems in pesticide useâ€"concerns about the health of agricultural workers, the ability of pests to develop resistance, issues of public perception, and more. Impending shifts in agricultureâ€"globalization of the economy, biological "invasions" of organisms, rising sensitivity toward cross-border environmental issues, and other trends. With a model and working examples, this book offers guidance on how to assess various pest control strategies available to today's agriculturist.

How can the United States meet demands for agricultural production while solving the broader range of environmental problems attributed to farming practices? National policymakers who try to answer this question confront difficult trade-offs. This book offers four specific strategies that can serve as the basis for a national policy to protect soil and water quality while maintaining U.S. agricultural productivity and competitiveness. Timely and comprehensive, the volume has important implications for the Clean Air Act and the 1995 farm bill. Advocating a systems approach, the committee recommends specific farm practices and new approaches to prevention of soil degradation and water pollution for environmental agencies. The volume details methods of evaluating soil management systems and offers a wealth of information on improved management of nitrogen, phosphorus, manure, pesticides, sediments, salt, and trace elements. Landscape analysis of nonpoint source pollution is also detailed. Drawing together research findings, survey results, and case examples, the volume will be of interest to federal, state, and local policymakers; state and local environmental and agricultural officials and other environmental and agricultural specialists; scientists involved in soil and water issues; researchers; and agricultural producers.

Historical perspective. Wildlife values in a Changing World. New patterns on land and water. Influence of land management on wildlife. Special problems of waters and watersheds. Pesticides and wildlife. Wildlife demage and control. Legislation and administration. Evaluation and Conclusions.

Many of the pesticides applied to food crops in this country are present in foods and may pose risks to human health. Current regulations are intended to protect the health of the general population by controlling pesticide use. This book explores whether the present regulatory approaches adequately protect infants and children, who may differ from adults in susceptibility and in dietary exposures to pesticide residues. The committee focuses on four major areas: Susceptibility: Are children more susceptible or less susceptible than adults to the effects of dietary exposure to pesticides? Exposure: What foods do infants and children eat, and which pesticides and how much of them are present in those foods? Is the current information on consumption and residues adequate to estimate exposure? Toxicity: Are toxicity tests in laboratory animals adequate to predict toxicity in human infants and children? Do the extent and type of toxicity of some chemicals vary by species and by age? Assessing risk: How is dietary exposure to pesticide residues associated with response? How can laboratory data on lifetime exposures of animals be used to derive meaningful estimates of risk to children? Does risk accumulate more rapidly during the early years of life? This book will be of interest to policymakers, administrators of research in the public and private sectors, toxicologists, pediatricians and other health professionals, and the pesticide industry.

Specialist Periodical Reports provide systematic and detailed review coverage of progress in the major areas of chemical research. Written by experts in their specialist fields the series creates a unique service for the active research chemist, supplying regular critical in-depth accounts of progress in particular areas of chemistry. For over 80 years the Royal Society of Chemistry and its predecessor, the Chemical Society, have been publishing reports charting developments in chemistry, which originally took the form of Annual Reports. However, by 1967 the whole spectrum of chemistry could no longer be contained within one volume and the series Specialist Periodical Reports was born. The Annual Reports themselves still existed but were divided into two, and subsequently three, volumes covering Inorganic, Organic and Physical Chemistry. For more general coverage of the highlights in chemistry they remain a 'must'. Since that time the SPR series has altered according to the fluctuating degree of activity in various fields of chemistry. Some titles have remained unchanged, while others have altered their emphasis along with their titles; some have been combined under a new name whereas others have had to be discontinued. The current list of Specialist Periodical Reports can be seen on the inside flap of this volume.

This book discusses studies that have been conducted on various animal species. The book reviews the effects of pesticides through changes in behavior, the nature of morphological and biochemical lesions, as well as the tracking of the metabolic disposition of pesticides in target sites of an organism. In vitro studies provide information regarding cellular responses and biochemical lesions with pesticides. Toxicological profiles of pesticides are cited using different species of animals for in vivo and in vitro studies. This information should help scientists and decision-makers reach conclusions regarding the toxicological effects of pesticides on humans and the environment.

When first developed, chlorinated pesticides such as DDT, dieldrin, and mirex were received with open arms, quickly becoming popular as effective, economic agents against pests. But evidence began to mount that residues of these chemicals remained in the environment, not breaking down, often appearing in plants and animals. By the late seventies many pesticides had achieved a terrible notoriety and were subsequently banned in a number of countries. Of tremendous concern, then, is the persistence of pesticides in the environment. The major thrust of research and development in the area of pesticides has properly been the creation of substances that are both effective and degradable. Yet in order to successfully promote the use of biodegradable pesticides, one must fully understand the mechanism of degradation, and it is to this vital subject that we address ourselves in the present volume. According to the Biodegradation Task Force, Safety of Chemicals Com mittee, Brussels (1978), biodegradation may be defined as the molecular degradation of an organic substance resulting from the complex action of living organisms. A substance is said to be biodegraded to an environmentally acceptable extent when environmentally undesirable properties are lost. Loss of some characteristic function or property of substance by biodegradation may be referred to as biological transformation.

Worldwide concern in scientific, indus hi aI, and governmental com munities over traces of toxic chemicals in foodstuffs and in both abiotic and biotic environments has justified the present triumvirate of specialized publications in this field: comprehensive reviews, rapidly published progress reports, and archival documentations. These three publications are integrated and scheduled to provide in international communication the coherency essential for nonduplicative and current progress in a field as dynamic and complex as environmental contamination and toxicology. Until now there has been no journal or other publication series reserved exclusively for the diversified literature on "toxic" chemicals in our foods, our feeds, our geographical surroundings, our domestic animals, our wild life, and ourselves. Around the world immense efforts and many talents have been mobilized to technical and other evaluations of natures, locales, magnitudes, fates, and toxicology of the persisting residues of these chemicals loosed upon the world. Among the sequelae of this broad new emphasis has been an inescapable need for an articulated set of authorita tive publications where one could expect to find the latest important world literature produced by this emerging area of science together with documentation of pertinent ancillary legislation.