In recent years, increasing concern has been voiced about the nature and extent of human experimentation and its impact on the investigator, subject, science, and society. This casebook represents the first attempt to provide comprehensive materials for studying the human experimentation process. Through case studies from medicine, biology, psychology, sociology, and law—as well as evaluative materials from many other disciplines—Dr. Katz examines the problems raised by human experimentation from the vantage points of each of its major participants—investigator, subject, professions, and state. He analyzes what kinds of authority should be delegated to these participants in the formulation, administration, and review of the human experimentation process. Alternative proposals, from allowing investigators a completely free hand to imposing centralized governmental control, are examined from both theoretical and practical perspectives. The conceptual framework of Experimentation with Human Beings is designed to facilitate not only the analysis of such concepts as "harm," "benefit," and "informed consent," but also the exploration of the problems raised by man's quest for knowledge and mastery, his willingness to risk human life, and his readiness to delegate authority to professionals and rely on their judgment.

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In the past few years an increasing number of colleges and universities have added courses in biomedical ethics to their curricula. To some extent, these additions serve to satisfy student demands for "relevance. " But it is also true that such changes reflect a deepening desire on the part of the academic community to deal effectively with a host of problems which must be solved if we are to have a health-care delivery system which is efficient, humane, and just. To a large degree, these problems are the unique result of both rapidly changing moral values and dramatic advances in biomedical technology. The past decade has witnessed sudden and conspicuous controversy over the morality and legality of new practices relating to abortion, therapy for the mentally ill, experimentation using human subjects, forms of genetic interven tion, suicide, and euthanasia. Malpractice suits abound and astronomical fees for malpractice insurance threaten the very possibility of medical and health-care practice. Without the backing of a clear moral consensus, the law is frequently forced into resolving these conflicts only to see the moral issues involved still hotly debated and the validity of existing law further questioned. In the case of abortion, for example, the laws have changed radically, and the widely pub licized recent conviction of Dr. Edelin in Boston has done little to foster a moral consensus or even render the exact status of the law beyond reasonable question.

Susan Lederer provides the first full-length history of early biomedical research with human subjects. Lederer offers detailed accounts of experiments conducted on both healthy and unhealthy men, women, and children, during the period from 1890 to 1940, including yellow fever experiments, Udo Wile's "dental drill" experiments on insane patients, and Hideyo Noguchi's syphilis experiments.

A chilling story of human depravity and ultimate justice, told for the first time by an eyewitness court reporter for the Nuremberg war crimes trial of Nazi doctors. This is the account of 22 men and 1 woman and the torturing and killing by experiment they authorized in the name of scientific research and patriotism. Doctors from Hell includes trial transcripts that have not been easily available to the general public and previously unpublished photographs used as evidence in the trial. The author describes the experience of being in bombed-out, dangerous, post-war Nuremberg, where she lived for two years while working on the trial. Once a Nazi sympathizer tossed bombs into the dining room of the hotel where she lived moments before she arrived for dinner. She takes us into the courtroom to hear the dramatic testimony and see the reactions of the defendants to the proceedings. This landmark trial resulted in the establishment of the Nuremberg code, which set the guidelines for medical research involving human beings. A significant addition to the literature on World War II and the Holocaust, medical ethics, human rights, and the barbaric depths to which human beings can descend.

During the Cold War, an alliance between American scientists, pharmaceutical companies, and the US military pushed the medical establishment into ethically fraught territory. Doctors and scientists at prestigious institutions were pressured to produce medical advances to compete with the perceived threats coming from the Soviet Union. In Against Their Will, authors Allen Hornblum, Judith Newman, and Gregory Dober reveal the little-known history of unethical and dangerous medical experimentation on children in the United States. Through rare interviews and the personal correspondence of renowned medical investigators, they document how children—both normal and those termed "feebleminded"—from infants to teenagers, became human research subjects in terrifying experiments. They were drafted as "volunteers" to test vaccines, doused with ringworm, subjected to electric shock, and given lobotomies. They were also fed radioactive isotopes and exposed to chemical warfare agents. This groundbreaking book shows how institutional superintendents influenced by eugenics often turned these children over to scientific researchers without a second thought. Based on years of archival work and numerous interviews with both scientific researchers and former test subjects, this is a fascinating and disturbing look at the dark underbelly of American medical history.

Testing with Humans, the sequel to bestseller Talking to Humans, teaches entrepreneurs, innovation teams, and product teams how to run effective experiments. An experiment is a test designed to help you answer the questions

Scientific experiments using animals have contributed significantly to the improvement of human health. Animal experiments were crucial to the conquest of polio, for example, and they will undoubtedly be one of the keystones in AIDS research. However, some persons believe that the cost to the animals is often high. Authored by a committee of experts from various fields, this book discusses the benefits that have resulted from animal research, the scope of animal research today, the concerns of advocates of animal welfare, and the prospects for finding alternatives to animal use. The authors conclude with specific recommendations for more consistent government action.

Ethical questions about the use of animals and humans in research remain among the most vexing within both the scientific community and society at large. These often rancorous arguments have gone on, however, with little awareness of their historical antecedents. Experimentation on animals and particularly humans is often assumed to be a uniquely modern phenomenon, but the ideas and attitudes that encourage the biological and medical sciences to experiment on living creatures date from the earliest expression of Western thought. Here, Anita Guerrini looks at the history of these practices from vivisection in ancient Alexandria to present-day battles over animal rights and medical research employing human subjects. Guerrini discusses key historical episodes, including the discovery of blood circulation, the development of smallpox and polio vaccines, and recent AIDS research. She also explores the rise of the antivivisection movement in Victorian England, the modern animal rights movement, and current debates over gene therapy.--From publisher description.